Late increase of serum S100 β protein levels in hamsters after oral or intraperitoneal infection with scrapie

Journal of Infectious Diseases

Volumn 180, Issue 2, 1999, Pages 518-520

  Beekes, Michael ^a   Otto, Markus ^b   Wiltfang, Jens ^c   Bahn, Erik ^b   Poser, Sigrid ^b   Baier, Michael ^a  

^a ROBERT KOCH INSTITUTE   (Germany)

^b Neurologische Klin Poliklin G   (Germany)

^c UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN S 100;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CREUTZFELDT JAKOB DISEASE; DIAGNOSTIC PROCEDURE; DISEASE MARKER; HAMSTER; MALE; NONHUMAN; PRION DISEASE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SCRAPIE;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL MARKERS; CRICETINAE; INJECTIONS, INTRAPERITONEAL; MALE; MESOCRICETUS; PRPSC PROTEINS; S100 PROTEINS; SCRAPIE; TIME FACTORS;

EID: 0033495904     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/314907     Document Type: Article

References (9)

1. 1. Otto M, Wiltfang J, Schuetz E, et al. Diagnosis of Creutzfeldt-Jakob disease by measurement of S100 protein in serum: prospective case-control study. BMJ 1998; 316:577-82.
2. 2. Otto M, Beekes M, Wiltfang J, Bahn E, Poser S, Diringer H. Elevated levels of serum S100 beta protein in scrapie hamsters. J Neurovirol 1998; 4:572-3.
3. 3. Isobe T, Ishioka N, Masuda T, Takahashi Y, Ganno S, Okuyama T. A rapid separation of S100 subunits by high-performance liquid chromatography: the subunit compositions of S100 proteins. Biochem Int 1983; 6:419-26.
4. 4. Van Eldik LJ, Jensen RA, Ehrenfried BA, Whetsell WO Jr. Immunohistochemical localization of S100 beta in human nervous system tumors by using monoclonal antibodies with specificity for the S100 beta polypeptide. J Histochem Cytochem 1986; 34:977-82.
5. 5. Mrak RE, Sheng JG, Griffin WS. Correlation of astrocytic S100 beta expression with dystrophic neurites in amyloid plaques of Alzheimer's disease. J Neuropathol Exp Neurol 1996; 55:273-9.
6. 6. Masters CL, Rohwer RG, Franko MC, Brown P, Gajdusek DC. The sequential development of spongiforrn change and gliosis of scrapie in the golden Syrian hamster. J Neuropathol Exp Neurol 1984; 43:242-52.
7. 7. Manuelidis L, Fritch W, Xi YG. Evolution of a strain of CJD that induces BSE-like plaques. Science 1997; 277:94-8.
8. 8. Baldauf E, Beekes M, Diringer H. Evidence for an alternative direct route of access for the scrapie agent to the brain bypassing the spinal cord. J Gen Virol 1997; 78:1187-97.
9. 9. Diringer H, Beekes M, Oberdieck U. The nature of the scrapie agent: the virus theory. Ann NY Acad Sci 1994; 724:246-58.