Identification of human cytomegalovirus target sequences in the human immunodeficiency virus long terminal repeat: Potential role of IE2-86 binding to sequences between -120 and -20 in promoter transactivation

Journal of Human Virology

Volumn 2, Issue 2, 1999, Pages 81-90

  Yurochko, Andrew D ^a   Huong, Shu Mei ^a   Huang, Eng Shang ^a,b  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

DNA binding; Human cytomegalovirus; Human immunodeficiency virus; Long terminal repeat; Transactivation

Indexed keywords

GENE PRODUCT;

ARTICLE; CYTOMEGALOVIRUS; DNA BINDING; FIBROBLAST; GENE MAPPING; HUMAN IMMUNODEFICIENCY VIRUS; LONG TERMINAL REPEAT; MOLECULAR INTERACTION; NONHUMAN; PRIORITY JOURNAL; TRANSACTIVATION; VIRUS CHARACTERIZATION;

BASE SEQUENCE; BINDING SITES; CELL LINE; CYTOMEGALOVIRUS; DNA, VIRAL; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, VIRAL; HELA CELLS; HIV LONG TERMINAL REPEAT; HUMANS; IMMEDIATE-EARLY PROTEINS; MEMBRANE GLYCOPROTEINS; PROMOTER REGIONS (GENETICS); RECOMBINANT FUSION PROTEINS; RESPONSE ELEMENTS; SEQUENCE DELETION; TATA BOX; TRANS-ACTIVATION (GENETICS); TRANS-ACTIVATORS; TRANSFECTION; VIRAL ENVELOPE PROTEINS; VIRAL PROTEINS;

CYTOMEGALOVIRUS; HUMAN HERPESVIRUS 5; HUMAN IMMUNODEFICIENCY VIRUS;

EID: 0033495185     PISSN: 10909508     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. Huang E-S, Kowalik TF. The pathogenicity of human cytomegalovirus: an overview. In: Becker Y, Darai G, Huang ES, eds. Molecular aspects of human cytomegalovirus diseases. Berlin, Germany: Springer-Verlag, 1993:1-45.
2. Shen CY, Ho MS, Chang SF, et al. High rate of concurrent genital infections with human cytomegalovirus and human papillomaviruses in cervical cancer patients. J Infect Dis 1993;168:449-452.
3. Ghazal P, Nelson JA. Interactions between cytomegalovirus immediate-early proteins and the long terminal repeat of human immunodeficiency virus. Rev Med Virol 1993;3:47-55.
4. Mocarski ES. Cytomegalovirus biology and replication. In: Roizman B, Whitley R, Lopez C, eds. The human herpesviruses. New York: Raven Press, 1993:173-226.
5. Stenberg RM. Immediate-early genes of human cytomegalovirus: organization and function. In: Becker Y, Darai G, Huang ES, eds. Molecular aspects of human cytomegalovirus diseases. Berlin, Germany: Springer-Verlag, 1993:330-359.
6. Ghazal P, Nelson JA. Transcription factors and viral regulatory proteins as potential mediators of human cytomegalovirus pathogenesis. In: Becker Y, Darai G, Huang ES, eds. Molecular aspects of human cytomegalovirus diseases. Berlin, Germany: Springer-Verlag, 1993:300-383.
7. Yurochko AD, Kowalik TF, Huong S-M, Huang E-S. HCMV upregulates NF-κB activity by transactivating the NF-κB p105/p50-and p65-promoters. J Virol 1995;69: 5391-5400.
8. Chiou C-J, Zong J, Waheed I, Hayward GS. Identification and mapping of dimerization and DNA-binding domains in the C terminus of the IE2 regulatory protein of human cytomegalovirus. J Virol 1993;67:6201-6214.
9. Schwartz R, Sommer MH, Scully A, Spector DH. Site-specific binding of the human cytomegalovirus IE2 86 kilodalton protein to an early gene promoter. J Virol 1994;68:5613-5622.
10. Lang D, Stamminger T. The 86-kilodalton IE-2 protein of human cytomegalovirus is a sequence-specific DNA-binding protein that interacts directly with the negative autoregulatory response element located near the cap site of the IE-1/2 enhancer-promoter. J Virol 1993;67:323-331.
11. Arlt H, Lang D, Gebert S, Stamminger T. Identification of binding sites for the 86-kilodalton IE2 protein of human cytomegalovirus within an IE2-responsive viral early promoter. J Virol 1994;68:4117-4125.
12. Hirsch MS, Curran J. Human immunodeficiency viruses. In: Fields BN, Knipe DM, Howley PM, eds. Fields' virology. Philadelphia: Lippincott-Raven Publishers, 1996: 1953-1975.
13. Geleziunas RH, Schipper HM, Wainberg MA. Pathogenesis and therapy of HIV-1 infection of the central nervous system. AIDS 1992;6:1411-1426.
14. Arribas JR, Storch GA, Clifford DB, Tselis AC. Cytomegalovirus encephalitis. Ann Intern Med 1996;125:577-587.
15. Nelson JA, Reynolds-Kohler C, Oldstone MB, Wiley CA. HIV and HCMV coinfect brain cells in patients with AIDS. Virology 1988;165:286-290.
16. Finkle C, Tapper MA, Knox KK, Carrigan DR. Coinfection of cells with the human immunodeficiency virus and cytomegalovirus in lung tissues of patients with AIDS. J Acquir Immune Defic Syndr 1991;4:735-737.
17. Toth FD, Mosberg-Peterson P, Kiss J, et al. Interactions between human immunodeficiency virus type 1 and human cytomegalovirus in human term syncytiotrophoblasts cells coinfected with both viruses. J Virol 1995;69: 2223-2232.
18. Rice GPA, Schrier RD, Oldstone MBA. Cytomegalovirus infects human lymphocytes and monocytes: virus expression is restricted to IE gene products. Proc Natl Acad Sci USA 1984;81:6134-6138.
19. Rando RF, Srinivasan A, Feingold J, Gonczol E, Plotkin S. Characterization of multiple molecular interactions between human cytomegalovirus (HCMV) and human immunodeficiency virus type 1 (HIV-1). Virology 1990;176: 87-97.
20. Markovitz DM, Kenney S, Kamine J, et al. Disparate effects of two herpesvirus immediate-early gene transactivators on the HIV-1 LTR. Virology 1989;173:750-754.
21. Biegalke BJ, Geballe AP. Sequence requirements for activation of the HIV-1 LTR by human cytomegalovirus. Virology 1991;183:381-385.
22. Walker S, Hagemeier C, Sissons JGP, Sinclair JH. A 10-base-pair element of the human immunodeficiency virus type 1 long terminal repeat (LTR) is an absolute requirement for transactivation by the human cytomegalovirus 72-kilodalton IE1 protein but can be compensated for by other LTR regions in transactivation by the 80-kilodalton IE2 protein. J Virol 1992;66:1545-1550.
23. Mosca JD, Bednarik DP, Raj NB, et al. Activation of human immunodeficiency virus by herpesvirus infection: identification of a region within the long terminal repeat that responds to a trans-acting factor encoded by herpes simplex virus 1. Proc Natl Acad Sci U S A 1987;84:7408-7412.
24. Ghazal P, Young J, Giulietti E, et al. A discrete cis element in the human immunodeficiency virus long terminal repeat mediates synergistic trans activation by cytomegalovirus immediate-early proteins. J Virol 1991;65:6735-6742.
25. Ho WZ, Song L, Douglas SD. Human cytomegalovirus infection and trans-activation of HIV-1 LTR in human brain-derived cells. J Acquir Immune Defic Syndr 1991; 4:1098-1106.
26. Barry PA, Pratt-Lowe E, Peterlin BM, Luciw PA. Cytomegalovirus activates transcription directed by the long terminal repeat of human immunodeficiency virus type 1. J Virol 1990;64:2932-2940.
27. Dal Monte P, Landini M-P, Sinclair J, Virelizier J-L, Michelson S. TAR and Sp1-independent transactivation of HIV long terminal repeat by the Tat protein in the presence of human cytomegalovirus IE1/IE2. AIDS 1996;11:297-303.
28. Kim S, Yu SS, Kim VN. Essential role of NF-κB in transactivation of the human immunodeficiency virus long terminal repeat by the human cytomegalovirus IE1 protein. J Gen Virol 1996;77:83-91.
29. Davis MG, Kenney SC, Kamine J, Pagano JS, Huang E-S. Immediate-early gene region of human cytomegalovirus trans-activates the promoter of human immunodeficiency virus. Proc Natl Acad Sci U S A 1987;84:8642-8646.
30. Ho W-Z, Harouse JM, Rando RF, Gonczol E, Srinivasan A, Plotkin SA. Reciprocal enhancement of gene expression and viral replication between human cytomegalovirus and human immunodeficiency virus type 1. J Gen Virol 1990;71:97-103.
31. Duclos H, Elfassi E, Michelson S, et al. Cytomegalovirus infection and transactivation of HIV-1 and HIV-2 LTRs in human astrocytoma cells. Res Hum Retroviruses 1989;5: 217-224.
32. Koval V, Clark C, Vaishnav M, Spector SA, Spector DH. Human cytomegalovirus inhibits human immunodeficiency virus replication in cells productively infected by both viruses. J Virol 1991;65:6969-6978.
33. Jault FM, Spector SA, Spector DH. The effects of cytomegalovirus on human immunodeficiency virus replication in brain-derived cells correlate with the permissiveness of the cells for each virus. J Virol 1994;68:959-973.
34. Moreno TN, Fortunato EA, Hsia K, Spector SA, Spector DH. A model system for human cytomegalovirus-mediated modulation of the human immunodeficiency virus type 1 long terminal repeat activity in brain cells. J Virol 1997;71:3693-3801.
35. Dobrescu D, Ursea B, Pope M, Asch AS, Posnett DN. Enhanced HIV-1 replication in Vb12 T cells due to human cytomegalovirus in monocytes: evidence for a putative herpesvirus superantigen. Cell 1996;82:753-763.
36. Huang E-S. Human cytomegalovirus. III. Virus-induced DNA polymerase. J Virol 1975;16:298-310.
37. Yuo CY, Wu GJ, Huang ES, Wu FY, Wu CW. Stable expression of functional human cytomegalovirus immediate-early proteins IE1 and IE2 in HeLa cells. Intervirology 1992;34:94-104.
38. Rosen CA, Sodroski JG, Haseltine WA. The location of cis-acting regulatory sequences in the human T cell lymphotropic virus type III (HTLV-III/LAV) long terminal repeat. Cell 1985;41:813-823.
39. Nabel GJ, Rice SA, Knipe DM, Baltimore D. Alternative mechanisms for activation of human immunodeficiency virus enhancer in T cells. Science 1988;239:1299-1302.
40. Furnari BA, Poma E, Kowalik TF, Huong SM, Huang E-S. Human cytomegalovirus immediate-early gene 2 protein interacts with itself and with several novel cellular proteins. J Virol 1993;67:4981-4991.
41. Yurochko AD, Mayo MW, Poma EE, Baldwin AS Jr, Huang E-S. Induction of the transcription factor Sp1 during human cytomegalovirus infection mediates upregulation of the p65 and p105/p50 NF-κB promoters. J Virol 1997;71:4638-4648.
42. Yurochko AD, Hwang E-S, Rasmussen L, Keay S, Pereira L, Huang E-S. The human cytomegalovirus UL55 (gB) and UL75 (gH) glycoprotein ligands initiate the rapid activation of Sp1 and NF-κB during infection. J Virol 1997; 71:5051-5059.
43. Pizzorno MC, Hayward GS. The IE2 gene products of the human cytomegalovirus specifically down-regulate expression from the major immediate-early promoter through a target sequence located near the cap site. J Virol 1990;64:6154-6165.
44. Scully AL, Sommer MH, Schwartz R, Spector DH. The human cytomegalovirus IE2 86-kilodalton protein interacts with an early gene promoter via site-specific DNA binding and protein-protein associations. J Virol 1995;69: 6533-6540.
45. Lukac DM, Harel NY, Tanese N, Alwine JC. TAF-like functions of human cytomegalovirus immediate-early proteins. J Virol 1997;71:7227-7239.
46. Lukac DM, Manuppello JR, Alwine JC. Transcriptional activation by the human cytomegalovirus immediate-early proteins: requirements for simple promoter structures and interactions with multiple components of the transcription complex. J Virol 1994;68:5184-5193.
47. Schwartz R, Helmich B, Spector DH. CREB and CREB-binding proteins play an important role in the IE2 86-kilodalton protein-mediated transactivation of the human cytomegalovirus 2.2-kilobase RNA promoter. J Virol 1996;70:6955-6966.
48. Lang D, Geben S, Arlt H, Stamminger T. Functional interaction between the human cytomegalovirus 86-kilodalton IE2 protein and the cellular transcription factor CREB. J Virol 1995;69:603-6037.
49. Yeung KC, Stoltzfus CM, Stinski MF. Mutations of the human cytomegalovirus immediate-early 2 protein defines regions and amino acid motifs important in transactivation of transcription from the HIV-1 LTR promoter. Virology 1993;195:786-792.