Sustained release of insulin from insoluble inhaled particles

Drug Development Research

Volumn 48, Issue 4, 1999, Pages 178-185

  Vanbever, Rita ^a,b,e   Ben Jebria, Abdellaziz ^b,c   Mintzes, Jeffrey D ^b,d   Langer, Robert ^a   Edwards, David A ^b,d  

^a Massachusetts Institute of Technology Cambridge   (United States)

^b The Pennsylvania State University   (United States)

^c INSERM   (France)

^d Advanced Inhalation Research Inc   (United States)

^e UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

Insoluble complex; Insulin; Large porous particles; Pulmonary delivery; Sustained release

Indexed keywords

ALBUMIN; DIPALMITOYLPHOSPHATIDYLCHOLINE; INSULIN; PROTAMINE; ZINC;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; DRUG BIOAVAILABILITY; DRUG FORMULATION; GEOMETRY; INSULIN BLOOD LEVEL; INSULIN TREATMENT; MALE; NONHUMAN; PARTICLE SIZE; RAT; STRUCTURE ACTIVITY RELATION; SUSTAINED RELEASE PREPARATION;

EID: 0033493161     PISSN: 02724391     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2299(199912)48:4<178::AID-DDR5>3.0.CO;2-I     Document Type: Article

References (30)

1. Adjei AL, Gupta PK. 1997. Inhalation delivery of therapeutic peptides and proteins. New York: Marcel Dekker.
2. Ando T, Yamasaki M, Suzuki K. 1973. Protamines, isolation, characterization, structure and function. In: Molecular biology biochemistry and biophysics, 12. New York: Springer-Verlag.
3. Ben-Jebria A, Chen D, Eskew M-L, Vanhever R, Langer R, Edwards DA. 1999. Inhalation oflarge porous albuterol particles for sustained bronchodilation. Pharm Res 16:555-561.
4. Budavari S. 1989. The Merck index: an encyclopedia of chemicals, drugs and biologicals. Rahway, NJ: Merck.
5. Chowhan ZT, Amaro AA. 1976. Pulmonary absorption studies utilising in situ rat lung model: designing dosage regimen for bronchial delivery of new drug entities. J Pharm 65:1669-1672.
6. Debs RJ, Straubinger RM, Brunette EN, Lin FJ, Montgomery AB, Friend DS, Papahadjopoulos DP. 1987. Selective enhancement of pentamidine uptake in the lung by aerosolization and delivery in liposomes. Am Rev Respir Dis 135:731-737.
7. Edwards DA, Hanes J, Caponetti G, Hrkach J, Ben-Jebria A, Eskew ML, Mintzes JD, Deaver D, Lotan N, Langer R. 1997. Large porous particles for pulmonary drug delivery. Science 276:1868-1871.
8. Edwards DA, Ben-Jebria A, Langer R. 1998. Recent advances in pulmonary drug delivery using large, porous inhaled particles. J Appl Physiol 85:379-385.
9. Effros RM. 1996. Solute transport following aerosol deposition in the lungs. In: Hickey AJ, editor. Inhalation aerosols: physical and biological basis for therapy. New York: Marcel Dekker.
10. European pharmacopoeia. 1997. 3rd ed. Strasbourg: Conseil de l'Europe, p 1044-1055.
11. European pharmacopoeia. Addendum 2000. 3rd ed. Strasbourg: Conseil de l'Europe, p 97-100.
12. French DL, Edwards DA, Niven RW. 1996. The influence of formulation on emission, deaggregation and deposition of dry powders for inhalation. J Aerosol Sci 27:769-783.
13. Hagedorn HC, Jensen BN, Kramp NB, Wodstrup I. 1936. Protamine insulinate. JAMA 106:177-180.
14. Hickey AJ. 1996. Inhalation aerosols - physical and biological basis for therapy. In: Lenfant C, editor. Lung biology in health and disease, 94. New York: Marcel Dekker.
15. Hickey AJ, Byron PR. 1986. Preparation, characterization and controlled release from coprecipitates of fluorescein and magnesium hydroxide. J Pharm Sci 75:756-759.
16. Komada F, Iwakawa S, Yamamoto N, Sakakibara H, Okumura K. 1994. Intratacheal delivery of peptide and protein agents: absorption from solution and dry powder by rat lung. J Pharm Sci 83:863-867.
17. Laemmli UK. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-685.
18. Laube BL, Benedict GW, Dobs AS. 1998. The lung as an alternative route of delivery for insulin in controlling postprandial glucose levels in patients with diabetes. Chest 114:1734-1739.
19. Lee VHL. 1992. Penetration enhancement for polypeptides through epithelia: (D) routes of delivery: case studies. Amsterdam: Elsevier.
20. Lewis DH. 1990. Controlled release of bioactive agents from lactide/ glycolide polymers. In: Chasin M, Langer R, editors. Biodegradable polymers as drug delivery systems, New York: Marcel Dekker. p 1-41.
21. Li W-I, Perzl M, Heyder J, Langer R, Brain JD, Englmeier K-H, Niven RW, Edwards DA. 1996. Aerodynamics and aerosol particle deaggregation phenomena in model oral-pharyngeal cavities. J Aerosol Sci 27:1269-1286.
22. Liu F-Y, Shao Z, Kildsig DO, Mitra AK. 1993. Pulmonary delivery of free and liposomal insulin. Pharm Res 10:228-232.
23. Okumura K, Iwakawa S, Yoshida T, Seki T, Komada F. 1992. Intratracheal delivery of insulin. Absorption from solution and aerosol by rat lung. Int J Pharm 88:1-3.
24. Okumara K, Komada F, Iwakawa S, Kinishi M, Amatsu M. 1994. Intratracheal delivery of calcitonin dry powder in rats and human volunteers. STP Pharma Sci 4:45-49.
25. Patton JS, Bukar J, Nagarajan S. 1999. Inhaled insulin. Adv Drug Deliv Rev 35:235-247.
26. Sayani AP, Chien YW. 1996. Systemic delivery of peptides and proteins across absorptive mucosae. Crit Rev Ther Drug Carrier Syst 13:85-184.
27. Vanbever R, Mintzes JD, Wang J, Nice J, Chen D, Baticky R, Langer R, Edwards DA. 1999. Formulation and physical characterization of large porous particles for inhalation. Pharm Res 16:1735-1742.
28. Wall DA. 1995. Pulmonary absorption of peptides and proteins. Drug Deliv 2:1-20.
29. Wang J, Ben-Jebria A, Edwards DA. 1999. Inhalation of estradiol for sustained systemic delivery. J Aerosol Med 12:27-32.
30. Zeng XM, Martin GP, Marriott C. 1995. The controlled delivery of drugs to the lung. Int J Pharm 124:149-164.