Synthesis and biological activity of 4-methyl-3,5-dioxane derivatives as thromboxane A2 receptor antagonists

Bioorganic and Medicinal Chemistry

Volumn 7, Issue 11, 1999, Pages 2635-2645

  Marusawa, Hiroshi ^a   Setoi, Hiroyuki ^a   Kuroda, Akio ^a   Sawada, Akihiko ^a   Seki, Jiro ^a   Motoyama, Yukio ^a   Tanaka, Hirokazu ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 15 HYDROXY 9ALPHA,11ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; 7 (3 FORMYLBICYCLO[2.2.1]HEPT 2 YL) 5 HEPTENOIC ACID 4 PHENYLSEMICARBAZONE; 7 [2 [2 AZA 2(((PHENYAMINO)THIOXOMETHYL)AMINO)VINYL] 4 METHYL 3,5 DIOXANYL]HEPT 5 ENOIC ACID; 7 [3 [(4 PHENYLSEMICARBAZIDO)METHYL] 7 OXABICYCLO[2.2.1]HEPT 2 YL] 5 HEPTENOIC ACID; ARACHIDONIC ACID; COLLAGEN; DIOXANE DERIVATIVE; SEMICARBAZIDE DERIVATIVE; SEMICARBAZONE DERIVATIVE; THROMBOXANE A2; THROMBOXANE A2 RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CONFORMATION; DRUG EFFICACY; DRUG POTENCY; DRUG SYNTHESIS; GUINEA PIG; HUMAN; HUMAN CELL; LUNG INFARCTION; MALE; MONKEY; MOUSE; NONHUMAN; RABBIT; RAT; STEREOCHEMISTRY; THROMBOCYTE AGGREGATION INHIBITION;

15-HYDROXY-11 ALPHA,9 ALPHA-(EPOXYMETHANO)PROSTA-5,13-DIENOIC ACID; ANIMALS; COLLAGEN; DIOXANES; DOGS; GUINEA PIGS; HAPLORHINI; HUMANS; MALE; MICE; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; RABBITS; RATS; RECEPTORS, THROMBOXANE; STRUCTURE-ACTIVITY RELATIONSHIP; THIOUREA; THROMBOXANE A2;

ANIMALIA; CAVIA PORCELLUS; ORYCTOLAGUS CUNICULUS; SUS SCROFA;

EID: 0033492221     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(99)00204-7     Document Type: Article

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