Performance characteristics of three serum iron and total iron-binding capacity methods in acute iron overdose

American Journal of Clinical Pathology

Volumn 112, Issue 5, 1999, Pages 657-664

  Roberts, William L ^a,d   Smith, P Todd ^b   Martin, Will John ^b   Rainey, Petrie M ^c  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d ARUP LABORATORIES   (United States)

Author keywords

Alumina; Assay interference; Deferoxamine; Iron; TIBC; Total iron binding capacity

Indexed keywords

ALUMINUM OXIDE; DEFEROXAMINE MESYLATE; IRON;

ANALYTICAL EQUIPMENT; ARTICLE; ASSAY; CHELATION THERAPY; DIAGNOSTIC ERROR; IRON BINDING CAPACITY; IRON BLOOD LEVEL; IRON OVERLOAD; PRIORITY JOURNAL;

EID: 0033491490     PISSN: 00029173     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcp/112.5.657     Document Type: Article

References (24)

1. Litovitz TL, Klein-Schwartz W, Dyer KS, et al. 1997 Annual report of the American Association of Poison Control Centers Toxic Exposure Surveillance System. Am J Emerg Med. 1998;16:443-497.
2. McGuigan MA. Acute iron poisoning. Pediatr Ann. 1996;25:33-38.
3. Henretig FM, Temple AR. Acute iron poisoning in children. Emerg Med Clin North Am. 1984;2:121-132.
4. Engle JP, Polin KS, Stile IL. Acute iron intoxication: treatment controversies. Drug Intell Clin Pharm. 1987;21:153-159.
5. Bryson PD, ed. Comprehensive Review in Toxicology. 2nd ed. Rockville, MD: Aspen; 1989:465-475.
6. Burkhart KK, Kulig KW, Hammond KB, et al. The rise in the total iron-binding capacity after iron overdose. Ann Emerg Med. 1991;20:532-535.
7. Tenenbein M, Yatscoff RW. The total iron-binding capacity in iron poisoning: is it useful? Am J Dis Child. 1991;145:437-439.
8. Thompson DF. Reassessment of measuring total iron binding capacity in acute iron overdose. Ann Pharmacother. 1994;28:63-66.
9. Proudfoot AT, Simpson D, Dyson EH. Management of acute iron poisoning. Med Toxicol. 1986;1:83-100.
10. Nelson WE, Behrman RE, Kleigman RM, et al, eds. Nelson Textbook of Pediatrics. 15th ed. Philadelphia, PA: Saunders; 1996:2019.
11. Bryson PD, ed. Comprehensive Review in Toxicology for Emergency Clinicians. 3rd ed. Washington DC: Taylor & Francis; 1996:623-633.
12. Barkin RM, Caputo GL, Jaffe DM, et al, eds. Pediatric Emergency Medicine: Concepts and Clinical Practice. 2nd ed. St Louis, MO: Mosby-Year Book; 1997:555-556.
13. Ellenhom MJ, Barceloux DG, eds. Medical Toxicology: Diagnosis and Treatment of Human Poisoning. New York, NY: Elsevier; 1988:1023-1030.
14. Haddad LM, Shannon MW, Winchester JF, eds. Clinical Management of Poisoning and Drug Overdose. 3rd ed. Philadelphia, PA: Saunders; 1998:757-766.
15. Helfer RE, Rodgerson DO. The effect of deferoxamine on the determination of serum iron and iron-binding capacity. J Pediatr. 1966;68:804-806.
16. Bentur Y, St Louis P, Klein J, et al. Misinterpretation of iron-binding capacity in the presence of deferoxamine. J Pediatr. 1991;118:139-142.
17. Siff JE, Meldon SW, Tomassoni AJ. Usefulness of the total iron binding capacity in the evaluation and treatment of acute iron overdose. Ann Emerg Med. 1999;31:73-76.
18. Gambino R, Desvarieux E, Orth M, et al. The relation between chemically measured total iron-binding capacity concentrations and immunologically measured transferrin concentrations in human serum. Clin Chem. 1997;43:2408-2412.
19. Keberle H. The biochemistry of desferrioxamine and its relation to iron metabolism. Ann N Y Acad Sci. 1964;119:758-768.
20. Steinmetz WL, Glick MR, Oei TO. Modified aca method for determination of iron chelated by deferoxamine and other chelators. Clin Chem. 1980;26:1593-1597.
21. Verhasselt B, Delanghe J, Verstraete A, et al. Colorimetric quantification of urinary iron during deferoxamine therapy. Clin Chem. 1994;40:497-498.
22. Kruck TPA, Teichert-Kuliszewska K. High-performance liquid chromatographic analaysis of desferrioxamine: pharmacokinetic and metabolic studies. J Chromatogr. 1988;433:207-216.
23. Chyka PA, Butler AY. Assessment of acute iron poisoning by laboratory and clinical observations. Am J Emerg Med. 1993;11:99-103.
24. Ellenhorn MJ, ed. Medical Toxicology: Diagnosis and Treatment of Human Poisoning. 2nd ed. Baltimore, MD: Williams & Wilkins; 1997:1558-1563.