Acid and the esophagus

Yale Journal of Biology and Medicine

Volumn 72, Issue 2-3, 1999, Pages 125-131

  McCarthy, Denis M ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b VA Medical Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); BILE ACID; BILIRUBIN; HYDROCHLORIC ACID; OMEPRAZOLE; PEPSIN A; PROTON PUMP INHIBITOR;

ACIDITY; ENZYME ACTIVITY; ESOPHAGITIS; ESOPHAGUS MUCOSA; ESOPHAGUS PH; EXPERIMENTAL MODEL; GASTROESOPHAGEAL REFLUX; NONHUMAN; REFLUX ESOPHAGITIS; REVIEW;

ANIMALS; GASTRIC ACID; GASTROESOPHAGEAL REFLUX; HUMANS; HYDROGEN-ION CONCENTRATION; MUCOUS MEMBRANE;

EID: 0033490755     PISSN: 00440086     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (25)

1. Ferguson, D.J., Sanchez-Palermo, E., Sako, Y., Clatworthy. H.W., Toon, R.W., and Wangensteen, O.H. Studies on experimental esophagitis. Surgery 28:1022-1039, 1950.
2. Cross, F.S. and Wangensteen, O.H. Role of bile and pancreatic juice in the production of experimental erosions and anemia. Proc. Soc. Exp. Biol. Med. 77:862-866, 1951.
3. Perry, J.F., Yonehiro, E.G., Root, H.D., and Wangensteen, O.H. Digestive action of human gastric juice. Proc. Soc. Exp. Biol. Med. 92:237-240, 1956.
4. Redo, S.F., Barnes, W.A., and De La Sierra, A. Perfusion of the canine esophagus with secretions of the upper GI tract. Ann. Surg., 149:556-564, 1959.
5. Goldberg, H.I., Dodds, W.J., Gee, S., Montgomery, C., and Zboralske, F. Role of acid and pepsin in acute experimental esophagitis. Gastroenterology 56:223-230, 1969.
6. Harmon, J.W., Johnson, L.F., and Maydonovitch, C.L. Effects of acid and bile salts on the rabbit esophageal mucosa. Dig. Dis. Sci. 26:65-72, 1981.
7. Lilliemoe, K.D., Johnson, L.F., and Harmon, J.W. Alkaline esophagitis: a comparison of the ability of components of gastroduodenal contents to injury the rabbit esophagus. Gastroenterology 85:621-628, 1983.
8. Lilliemoe, K.D., Johnson, L.F., and Harmon, J.W. Taurodeoxycholate modulates the effects of pepsin and trypsin in experimental esophagitis. Surgery 97:662-667, 1985.
9. + in the pathogenesis of experimental esophagitis. Surgery 92:61-68, 1982.
10. Gotley, D.C., Ball, D.E., Owen, R.W., Williamson, R.C.N., and Cooper, M.J. Evaluation and surgical correction of esophagitis after partial gastrectomy. Surgery 111:29-36, 1992.
11. Hirschowitz, B.I. A critical analysis with appropriate controls, of gastric acid and pepsin secretion in clinical esophagitis. Gastroenterology 101:1149-1158, 1991.
12. Vaezi, M.F., Singh, S., and Richter, J.E. Role of acid and duodenogastric reflux in esophageal mucosal injury. Gastroenterology 108:1897-1907, 1995.
13. Vaezi, M.F. and Richter, J.E. Role of acid and duodeno-gastroesophageal reflux in gastroesophageal reflux disease. Gastroenterology 111:1192-1199, 1996.
14. Vaezi, M.F. and Richter, J.E. Contribution of acid and duodeno-gastroesophageal reflux to esophageal mucosal injury and symptoms in partial gastrectomy patients. Gut 41:297-302, 1997.
15. Turner, K.S., Powell, D.W., Carney, C.N., Orlando, R.C., and Bozymski, E. Transmural electrical potential difference in the mammalian esophagus in vivo. Gastroenterology 75:286-291, 1978.
16. Carney, C.N., Orlando, R.C., Powell, D.W., and Dotson, M.M. Morphologic alterations in early acid-induced epithelial injury in the rabbit esophagus. Lab. Invest. 45:198-208, 1981.
17. Orlando, R.C., Powell, D.W., and Carney, C.N. Pathophysiology of acute acid injury in rabbit esophageal epithelium. J. Clin. Invest. 68:286-293, 1981.
18. +-induced injury in rabbit esophageal epithelium. Am. J. Physiol. 246:G718-724, 1984.
19. Orlando, R.C., Lacy, E.R., Tobey, N.E., and Cowart, K. Barriers to paracellular permeability in rabbit esophageal epithelium. Gastroenterology 102:910-923, 1992.
20. Tobey, N.E., Carson, J.L., Alkiek, R.A., and Orlando, R.C. Dilated intracellular spaces: a morphological feature of acid-reflux-damaged human esophageal epithelium. Gastroenterology 111:1200-1205, 1996.
21. Carlsson, R., Fandricks, L., Jönsson, C., Lundell, L., Orlando, R. Is the squamous epithelial barrier function impaired in patients with gastroesophageal reflux disease (GERD). Gut 41:A57, 1997.
22. Dunne, D., Kosseva, V., and Paterson, W.G. Severity of reflux symptoms correlates with esophageal acid exposure in a non-referred population of heartburn sufferers. Gastroenterology 112:A108, 1997.
23. Trimble, K.C., Pryde, A., and Heading, R.C. Lower esophageal sensory thresholds in patients with symptomatic but not excess gastroesophageal reflux: evidence for a spectrum of visceral sensitivity in GERD. Gut 37:7-12, 1995.
24. Sarkar, S., Woolf, C.J., Aziz, O., and Thompson, D.G. Secondary hyperalgesia is induced by acid in the healthy human esophagus. Gut 41(suppl 3):A26, 1997.
25. Ward, S.J., Hobson, A., Bancewicz, J., and Bralow, J. Oesophageal sensory thresholds in acid reflux vary according to the type of stimulus applied. Gut 41(suppl 3):A57, 1997.