Cytokeratin 34βE-12 immunoreactivity in benign prostatic acini: Quantitation, pattern assessment, and electron microscopic study

American Journal of Clinical Pathology

Volumn 112, Issue 1, 1999, Pages 69-74

  Goldstein, Neal S ^a   Underhill, Jeanette ^a   Roszka, Joseph ^a   Neill, James S ^a  

^a WILLIAM BEAUMONT HOSPITAL   (United States)

Author keywords

Adenocarcinoma; Basal cells; Electron microscopy; Immunohistochemistry; Keratin 34 E 12; Prostate

Indexed keywords

CYTOKERATIN;

ACINAR CELL; ARTICLE; BASAL CELL; ELECTRON MICROSCOPY; HUMAN; HUMAN TISSUE; IMMUNOREACTIVITY; MALE; PRIORITY JOURNAL; PROSTATE ADENOCARCINOMA; PROSTATECTOMY;

EID: 0033490587     PISSN: 00029173     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajcp/112.1.69     Document Type: Article

References (22)

1. Gown AM, Vogel AM. Monoclonal antibodies to human intermediate filament proteins, II: distribution of filament proteins in normal human tissues. Am J Pathol. 1984;114:309-321.
2. Brawer MK, Peehl DM, Stamey TA, et al. Keratin immunoreactivity in the benign and neoplastic human prostate. Cancer Res. 1985;45:3663-3667.
3. Dhom G, Seitz G, Wernert N. Histology and immunohistochemistry studies in prostate cancer. Am J Clin Oncol. 1988;11(suppl 2):S37-S42.
4. Epstein JI. The diagnosis and reporting of adenocarcinoma of the prostate in core needle biopsy specimens. Cancer. 1996;78:350-356.
5. Guinan P, Shaw M, Targonski P, et al. Evaluation of cytokeratin markers to differentiate between benign and malignant prostate tissue. J Surg Oncol. 1989;42:175-180.
6. Hedrick L, Epstein JI. Use of keratin 903 as an adjunct in the diagnosis of prostate carcinoma. Am J Surg Pathol. 1989;13:389-396.
7. Kahane H, Sharp JW, Shuman GB, et al. Utilization of high molecular weight cytokeratin on prostate needle biopsies in an independent laboratory. Urology. 1995;45:981-986.
8. Nagle RB, Ahmann FR, McDaniel KM, et al. Cytokeratin characteristics of human prostatic carcinoma and its derived cell lines. Cancer Res. 1987;47:281-286.
9. O'Malley FP, Grignon DJ, Shum DT. Usefulness of immunoperoxidase staining with high-molecular-weight cytokeratin in the differential diagnosis of small-acinar lesions of the prostate. Virchows Arch A Pathol Anat Histol. 1990;417:191-196.
10. Okada H, Tsubura A, Okamura A, et al. Keratin profiles in normal/hyperplastic prostates and prostate carcinoma. Virchows Arch A Pathol Anat Histol. 1992;421:157-161.
11. Shah IA, Schlageter M-O, Stinnett P, et al. Cytokeratin immunohistochemistry as a diagnostic tool for distinguishing malignant from benign epithelial lesions of the prostate. Mod Pathol. 1991;4:220-224.
12. Sherwood ER, Theyer G, Steiner G, et al. Differential expression of specific cytokeratin polypeptides in the basal and luminal epithelia of the human prostate. Prostate. 1991;18:303-314.
13. Wojno KJ, Epstein JI. The utility of basal cell-specific anti-cytokeratin antibody (34βE12) in the diagnosis of prostate cancer: a review of 228 cases. Am J Surg Pathol. 1995;19:251-260.
14. Cheville JC, Bostwick DG. Postatrophic hyperplasia of the prostate. Am J Surg Pathol. 1995;19:1068-1076.
15. Putzi MJ, Wojno KJ. Characterization of apparent false negative staining for 34βE12 in BPH nodules [abstract]. Mod Pathol. 1998;11:93A.
16. Kitajima K, Tokes ZA. Immunohistochemical localization of keratin in human prostate. Prostate. 1986;9:183-190.
17. Sinha AA, Blackard CE. Ultrastructure of prostatic benign hyperplasia and carcinoma. Urology. 1973;2:114-120.
18. Kastendieck H, Altenahr E. Cyto- and histomorphogenesis of the prostate carcinoma: a comparative light- and electron-microscopic study. Virchows Arch A Pathol Anat Histol. 1976;370:207-224.
19. Trump BF, Heatfield BM, Phelps PC. The role of the cytoskeleton and related components in normal and neoplastic prostatic epithelium. Prog Clin Biol Res. 1981;75A:25-53.
20. Fisher ER, Sieracki JC. Ultrastructure of human normal and neoplastic prostate. Pathol Ann. 1970;5:1-26.
21. Srigley JR, Dardick I, Hartwick RWJ, et al. Basal epithelial cells of human prostate gland are not myoepithelial cells: a comparative immunohistochemical and ultrastructural study with the human salivary gland. Am J Pathol. 1990;136:957-966.
22. Mao P, Angist A. The fine structure of the basal cell of human prostate. Lab Invest. 1966;15:1768-1782.