Comparative anorectic effects of metaraminol and phenylephrine in rats

Physiology and Behavior

Volumn 68, Issue 1-2, 1999, Pages 227-234

  Yeh, S Y ^a  

^a NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

Author keywords

2 Amino 1 (m hydroxyphenyl) 1 propanol; 2 Methylamino 1 (m hydroxyphenyl) 1 ethanolamine; Anorexia; Body weight; Locomotor activity; Metaraminol; Phenylephrine

Indexed keywords

AMPHETAMINE DERIVATIVE; METARAMINOL; PHENYLEPHRINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANOREXIA; ARTICLE; BODY WEIGHT; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG EFFECT; FOOD INTAKE; LOCOMOTION; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION;

EID: 0033459478     PISSN: 00319384     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0031-9384(99)00180-8     Document Type: Article

References (16)

1. Yeh S.Y. Comparative anorectic effects of α-methylepinephrine and 4-hydroxyephedrine in the rat. Pharmacologist. 35:1993;185.
2. Yeh S.Y. Comparative anorectic effects of α-methylnorepinephrine, 4-hydroxynorephedrine and α-methyldopamine in rats. Soc Neurosci Abstr. 19:1993;1238.
3. Yeh SY. Anorectic and stimulatory effects of phenylpropanolamine. Society of Chinese Bioscientists in America. The 5th International Symposium & Workshops, vol. 5, 1993. p. 183.
4. Antunes-Rodrigues J., McCann S.M. Water, sodium chloride, and food intake induced by injections of cholinergic and adrenergic drugs into the third ventricle of rat brain. Proc Soc Exp Biol Med. 33:1970;1464-1470.
5. Shoji T., Sakurada S., Kisara K. Central effects of β-phenylethylamines. Increase in spontaneous motor activities of mice caused by intracerebrally administered metaraminol. Nippon Yakurigaku Zasshi. 73:1977;15-23.
6. Lora-Vilchis M.C., Rodriguez-Zendejas A.M., Soto-Mora L.M., Russek M., Epstein A.N. Ontogeny of alpha- and beta-adrenergic anorexia in rats. Am J Physiol. 255:1988;R908-R913.
7. Wellman P.J., Davies B.T., Morien A., McMahon L. Modulation of feeding by hypothalamic paraventricular nucleus α1 and α2-adrenergic receptors. Life Sci. 53:1993;669-679.
8. Morien A., McMahon L., Wellman P.J. Effects on food and water intake of the β-adrenoceptor agonists amidephrine and SK & F-89748. Life Sci. 53:1993;169-174.
9. Wellman P.J., Davies B.T. Suppression of feeding induced by phenylephrine microinjection within the paraventricular hypothalamus in rats. Appetite. 17:1991;121-128.
10. Dixon WJ, Brown MB, Engelman L, Jennrich RI. BMDP Statistical Software Manual. Berkeley, CA, l990.
11. Finney D.J. Statistical Methods in Bioassay. 1971;Griffin, London.
12. Foltin R.W. Effects of anorectic drugs on the topography of feeding behavior in baboons. J Pharmacol Exp Ther. 249:1989;101-109.
13. Grinker J.A., Drewnowski A., Enns M., Kissileff H. Effects of d-amphetamine and fenfluramine on feeding patterns and activity of obese and lean Zucker rats. Pharmacol Biochem Behav. 12:1980;265-275.
14. Beregi L.G., Hugon P., LeDouarec J.C., Laubie M., Duhault J. Structure-activity relationships in the CF3 substituted phenethylamines. Costa E., Garattini S. Amphetamines and Related Compounds. 1970;21-61 Plenum Press, New York.
15. Fuller R.W., Snoddy H.D., Perry K.M. Tissue levels of metaraminol and its metabolite, alpha-methylnorepinephrine in control and 6-hydroxydopamine-pretreated guinea pigs. Life Sci. 29:1981;1271-1275.
16. Fuller R.W., Snoddy H.D., Perry K.W., Bernstein J.R., Murphy P.J. Formation of α-methylnorepinephrine as a metabolite of metaraminol in guinea pigs. Biochem Pharmacol. 30:1981;2831-2836.