Differential substrate behaviours of ethylene oxide and propylene oxide towards human glutathione transferase theta hGSTT1-1

Archives of Toxicology

Volumn 73, Issue 8-9, 1999, Pages 489-492

  Thier, Ricarda ^a   Wiebel, Frederike A ^a   Bolt, Hermann M ^a  

^a LEIBNIZ RESEARCH CENTRE FOR WORKING ENVIRONMENT AND HUMAN FACTORS   (Germany)

Author keywords

Butylene oxide; Ethylene oxide; Glutathione transferase theta; Methyl bromide; Propylene oxide

Indexed keywords

ETHYLENE OXIDE; GLUTATHIONE TRANSFERASE; ISOENZYME; METHYL BROMIDE; ORGANOBROMINE DERIVATIVE; PROPYLENE OXIDE; RECOMBINANT ENZYME;

ARTICLE; CHEMOREACTIVITY; CONTROLLED STUDY; DEGRADATION; HEMOLYSATE; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REACTION ANALYSIS; TOXICOKINETICS;

EID: 0033455526     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002040050640     Document Type: Article

References (12)

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7. Peter H, Deutschmann S, Reichel C, Hallier E (1989) Metabolism of methyl chloride in human erythrocytes. Arch Toxicol 63:351-355
8. Thier R, Taylor JB, Pemble SE, Humphreys WG, Persmark M, Ketterer B, Guengerich FP (1993) Expression of mammalian glutathione S-transferase 5-5 in Salmonella typhimurium TA1535 leads to base-pair mutations upon exposure to dihalomethanes. Proc Natl Acad Sci USA 90: 8576-8580
9. Thier R, Pemble SE, Kramer H, Taylor JB, Guengerich FP, Ketterer B (1996) Human glutathione S-transferase T1-1 enhances mutagenicity of 1,2-dibromoethane, dibromomethane and 1,2,3,4-diepoxybutane in Salmonella typhimurium. Carcinogenesis 17: 163-167
10. Thier R, Wiebel FA, Hinkel A, Burger A, Brüning T, Morgenroth K, Senge T, Wilhelm M, Schulz TG (1998) Species differences in the glutathione transferase GSTT1-1 activity towards the model substrates methyl chloride and dichloromethane in liver and kidney. Arch Toxicol 72: 622-629
11. Thier R, Lewalter J, Kempkes M, Selinski S, Brüning T, Bolt HM (1999) Haemoglobin adducts of acrylonitrile and ethylene oxide in acrylonitrile workers, dependent on polymorphisms of the glutathione transferases GSTT1 and GSTM1. Arch Toxicol 73: 197-202
12. Wiebel FA, Dommermuth A, Thier R (1999) The hereditary transmission of the glutathione transferase hGST1-1 conjugator phenotype in a large family. Pharmacogenetics 9: 251-256