A close and critical examination of how psychopharmacotherapy research is conducted

Journal of Mind and Behavior

Volumn 20, Issue 3, 1999, Pages 311-350

  Jacobs, David H ^a  

^a Psychotherapy Associates   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLINICAL RESEARCH; DIAGNOSTIC ERROR; DRUG EFFICACY; DRUG SAFETY; PSYCHOPHARMACOTHERAPY; REVIEW;

EID: 0033454719     PISSN: 02710137     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (116)

1. Ananth, J. (1984). Physical illness and psychiatric disorders. Comprehensive Psychiatry, 25, 586-593.
2. Andreason, N.D., and Carpenter, Jr., W.T. (1993). Diagnosis and classification of schizophrenia. Schizophrenia Bulletin, 19, 25-40.
3. Andrews, G., Steward, G., Morris-Yates, A., Holt, P., and Henderson, S. (1990). Evidence for a general neurotic syndrome. British Journal of Psychiatry, 157, 6-12.
4. Antonuccio, D.O., Danton, W.G., and DeNelsky, G.Y. (1995). Psychotherapy vs. medication for depression: Challenging the conventional wisdom with data. Professional Psychology: Research and Practice, 26, 574-585.
5. Austin, S.C., Stolley, P.D., and Lasky, T. (1992). The history of malariotherapy for neurosyphillis. Journal of the American Medical Association, 268, 516-519.
6. Bleuler, M. (1978). The schizophrenic disorders: Long-term patient and family studies. New Haven, Connecticut: Yale University Press.
7. Bleuler, M. (1991). The concept of schizophrenia in Europe during the past one hundred years. In W.F. Flack, Jr. and D.R. Miller (Eds.), What is schizophrenia? (pp. 1-16). New York: Springer-Verlag.
8. Bogerts, B. (1993). Recent advances in the neuropathology of schizophrenia. Schizophrenia Bulletin, 19, 257-271.
9. 2 receptor gene and alcoholism. Journal of the American Medical Association, 26, 3156-3160.
10. Breggin, P.R. (1983). Psychiatric drugs: Hazards to the brain. New York: Springer Publishing Company.
11. Breggin, P.R. (1991). Toxic psychiatry. New York: St. Martin's press.
12. Breggin, P.R. (1993). Parallels between neuroleptic effects and lethargic encephalitis. Brain and Cognition, 23, 8-27.
13. Breggin, P.R. (1997). Brain disabling treatments in psychiatry. New York: Springer Publishing Company.
14. Byerley, W.F., Reinherr, F.W., Wood, D.R., and Grosser, B.I. (1988). Fluoxetine, a selective serotonin uptake inhibitor, for the treatment of outpatients with major depression. Journal of Clinical Psychopharmacology, 8, 112-115.
15. Caine, E.D., and Shoulson, I. (1983). Psychiatric syndromes in Huntington's Disease. American Journal of Psychiatry, 140, 728-733.
16. Carpenter, Jr., W.T., McGlashan, T.H., and Strauss, J.S. (1977). The treatment of acute schizophrenia without drugs: An investigation of some current assumptions. American Journal of Psychiatry, 134, 14-20.
17. Carson, R.C., and Sanislow, A. (1993). The schizophrenias. In P.B. Sutker and H.E. Adams (Eds), Comprehensive handbook of psychopathology (pp. 295-333). New York: Plenum Books.
18. Ciompi, L. (1997). The Soteria-concept. Theoretical bases and practical 13-year-experience with a mileu-therapeutic approach of acute schizophrenia. Psychiatrica et Neurologia Japonica, 99, 634-650.
19. Clark, L.D. (1956). Evaluation of the therapeutic effects of drugs in psychiatric patients. Diseases of the Nervous System, 17, 282-286.
20. Cochrane, A.L. (1972). Effectiveness and efficiency. London: Burgess & Son Ltd.
21. Cohen, D. (1997). A critique of the use of neuroleptic drugs in psychiatry. In S. Fisher and R.P. Greenberg (Eds.), From placebo to panacea: Putting psychiatric drugs to the test (pp. 173-228). New York: John Wiley and Sons, Inc.
22. Cohn, J.B., and Wilcox, C. (1985). A comparison of fluoxetine, imipramine, and placebo in patients with major depressive disorder. Journal of Clinical Psychiatry, 46, 26-31.
23. Cole, J.O. (1960). Behavioral toxicity. In L. Uhr and J.G. Miller (Eds.), Drugs and behavior (pp. 166-183). New York: John Wiley and Sons, Inc.
24. Dinnerstein, A.J., Lowenthal, J., and Blitz, B. (1966). The interaction of drugs with placebos in the control of pain and anxiety. Perspectives in Biology and Medicine, 10, 103-117.
25. Dubos, R. (1965). Man adapting. New Haven: Yale University Press.
26. Dumont, M.P. (1984). The nonspecificity of mental illness. American Journal of Orthopsychiatry, 54, 326-334.
27. Duster, T. (1984). A social frame for biological knowledge. In T. Duster and K. Garrett (Eds.), Cultural perspectives on biological knowledge (pp. 1-40). Norwood, New Jersey: Ablex Publishing Co.
28. Duster, T. (1990). Backdoor to eugenics. New York: Routledge.
29. Easton, K., and Link, I. (1986). Do neuroleptics prevent relapse? Clinical observations in a psychosocial rehabilitation program. Psychiatry Quarterly, 58, 42-50.
30. Edwards, J.H. (1991). The formal problems of linkage. In P. McGuffing and R. Murray (Eds.), The new genetics of mental illness (pp. 53-69). London: Reed International Books.
31. Eisenberg, L. (1980). What makes persons "patients" and patients "well"? The American Journal of Medicine, 69, 277-286.
32. Elkin, I., Shea, M.T., Watkins, J.T., Imber, S.D., Sotsky, S.M., Collins, J.F., Glass, D.R., Dilkonis, D.A., Leber, W.R., Docherty, J.P., Fiester, S.J., and Parloff, M.B. (1989). National Institute of Mental Health treatment of depression collaborative research program. Archives of General Psychiatry, 46, 971-982.
33. Engel, G.L. (1977). The need for a new medical model: A challenge to biomedicine. Science, 196, 129-136.
34. Fisher, C.M. (1989). Neurologic fragments II. Remarks on anosognosia, confabulation, memory, and other topics. Neurology, 39, 127-132.
35. Frances, A.J., First, M.B., Widiger, T.A., Miele, G.M., Tilly, S., Davis, W.W., and Pincus, H.A. (1991). An A to Z guide to DSM-IV conundrums. Journal of Abnormal Psychology, 100, 407-412.
36. Gevirtz, R.N., Hubbard, D.R., and Harpin, E.R. (1996). Psychophysiologic treatment of lower back pain. Professional Psychology: Research and Practice, 27, 561-566.
37. Gilmour, R. (1977). Psychological factors in clinical trials. In F.N. Johnson and S. Johnson (Eds). Clinical trials (pp. 147-161). London: Blackwell Scientific Publications.
38. Golombok, S., Parmala, M., and Lader, M. (1988). Cognitive impairment in long-term benzodiazepine users. Psychological Medicine, 18, 365-374.
39. Gram, L.F. (1994). Fluoxetine. The New England Journal of Medicine, 331, 1354-1361.
40. Greenberg, R.P., Bornstein, R.F., Greenberg, M.D., and Fisher, S. (1992). A meta-analysis of antidepressant outcome under "blinder" conditions. Journal of Consulting and Clinical Psychology, 60, 664-669.
41. Greenberg., R.P., and Fisher, S. (1989). Examining antidepressant effectiveness. In S. Fisher and R.P. Greenberg (Eds.), The limits of biological treatment for psychological distress (pp. 1-37). Hillsdale, New Jersey: Lawrence Erlbaum Associates.
42. Hamilton, M. (1960). A rating scale for depression. Journal of Neurology, Neurosurgery, and Psychiatry, 23, 56-62.
43. Heinrichs, R.W. (1993). Schizophrenia and the brain: Conditions for a neuropsychology of madness. American Psychologist, 48, 221-232.
44. Hoehn-Saric, R., Lipsey, J.R., and McLeod, D.A. (1990). Apathy and indifference in patients on fluvoxamine and fluoxetine. Journal of Clinical Psychopharmacology, 10, 343-345.
45. Hoffman, R.S. (1982). Diagnostic errors in the evaluation of behavioral disorders. Journal of the American Medical Association, 248, 964-967.
46. Hyman, S.E. (1996). Introduction from the new NIMH Director. Psychotherapy and Rehabilitation Research Bulletin, 5, 1-2.
47. Hyman, S.E., and Nestler, E.J. (1996). Initiation and adaptation: A paradigm for understanding psychotropic drug action. American Journal of Psychiatry, 153, 151-162.
48. Janicak, P.G., Davis, J.M., Preskorn, S.H., and Ayd, Jr., F.J. (1993). Principles and practices of psychopharmacotherapy. Baltimore: Williams & Wilkins.
49. Judd, L.L., and Hubbard, B.R. (1975). The effects of lithium carbonate on sodium phenobarbital induced high in normal subjects. Psychopharmacology Communications, 1, 631-639.
50. Judd, L.L., Hubbard, B.R., Janowsky, D.S., Leighton, H.Y., and Attewell, P.A. (1977). The effect of lithium carbonate on affect, mood and personality of normal subjects. Archives of General Psychiatry, 34, 346-351.
51. Karon, B.P. (1989). Psychotherapy vs. medications for schizophrenia. In S. Fisher and R.P. Greenberg (Eds.). The limits of biological treatment for psychological distress (pp. 105-150). Hillsdale, New Jersey: Lawrence Erlbaum Associates, Publishers.
52. Karp, D.A. (1993). Taking anti-depressant medications: Resistence, trial commitment, conversion, disenchantment. Qualitative Sociology, 16, 337-359.
53. Karp, D.A. (1996). Speaking of sadness. New York: Oxford University Press.
54. Kendell, R.E. (1988). What is a case? Food for thought for epidemiologists. Archives of General Psychiatry, 45, 374-376.
55. Kendell, R.E. (1991). Schizophrenia: A medical view of a medical concept. In W.F. Flack, Jr., D.R. Miller, and M. Wiener (Eds.), What is schizophrenia? (pp. 59-72). New York: Springer-Verlag.
56. Kendell, R.E., and Brockington, I.F. (1980). The identification of disease entities and the relationship between schizophrenia and the affective psychoses. British Journal of Psychiatry, 137, 324-331.
57. King, R.A., Riddle, M.A., Chappell, P.B., Hardin, M.T., Anderson, G.M., Lombroso, P., and Kahili, L. (1991). Emergence of self-destructive phenomena in children and adolescents during fluoxetine treatment. Journal of the American Academy of Child and Adolescent Psychiatry, 30, 179-186.
58. Kirch, D.G. (1993). Infection and autoimmunity as etiologic factors in schizophrenia. Schizophrenia Bulletin, 19, 181-196.
59. Klerman, G.L. (1978). The evolution of a scientific nosology. In J.D. Shershow (Ed.), Schizophrenia: Science and practice (pp. 99-119). Cambridge, Massachusetts: Harvard University Press.
60. Klerman, G.L. (1988). Overview of the cross-national collaborative panic study. Archives of General Psychiatry, 45, 407-412.
61. Lambert, M.J., Hatch, D.R., Kingston, M.D., and Edwards, B.C. (1986). Zung, Beck, and Hamilton rating scales as measures of treatment outcome: A meta-analytic comparison. Journal of Consulting and Clinical Psychology, 54, 54-59.
62. Lewontin, R.C., Rose, S., and Kamin, L.J. (1984). Not in our genes. New York: Pantheon Books.
63. Lidz, T., Blatt, S., and Cook, B. (1981). Critique of the Danish-American studies of the adopted-away offspring of schizophrenic parents. American Journal of Psychiatry, 138, 1063-1068.
64. Lieberman, J.A., and Koreen, A.R. (1993). Neurochemistry and neuroendocrinology of schizophrenia: A selective review. Schizophrenia Bulletin, 19, 197-256.
65. Lipinski, Jr., J.F., Mallaya, G., Zimmerman, P., and Pope, Jr., H.G. (1989). Fluoxetine-induced akathisia: Clinical and theoretical implications. Journal of Clinical Psychiatry, 50, 339-342.
66. Marholin, D., and Philips, D. (1976). Methodological issues in psychopharmacological research. American Journal of Orthopsychiatry, 46, 477-495.
67. Marks, I. Swinson, R.P., Basoglu, M. Noshirvani, H., O'Sullivan, G, Lelliott, P.T., Kirby, M., McNamee, G., Sengun, S., and Wickwire, K. (1993). Alprazolam and exposure alone and combined in panic disorder with agoraphobia. British Journal of Psychiatry, 162, 776-787.
68. Marshall, E. (1994). Manic depression: Highs and lows on the research roller coaster. Science, 264, 1693-1695.
69. Mavissakalian, M., and Michelson, L. (1986). Two-year follow-up of exposure and imipramine treatment of agoraphobia. American Journal of Psychiatry, 143, 1106-1112.
70. McHugh, P.R. (1991). Schizophrenia and the disease model. In W.F. Flack, Jr., D.R. Miller, and M. Weiner (Eds), What is schizophrenia? (pp. 73-80). New York: Springer-Verlag.
71. Menn, A.Z., and Mosher, L. (1982). Forward. In H.S. Wilson, Deinstitutionalized residential care for the mentally disordered (pp. xi-xv). New York: Grune and Stratton.
72. Mesulam, M.M. (1990). Schizophrenia and the brain. The New England Journal of Medicine, 322, 842-844.
73. Milrod, B. (1995). The continued usefulness of psychoanalysis in the treatment armamentarium for panic disorder. Journal of the American Psychoanalytic Association, 43, 151-162.
74. Milrod, B., Busch, F.N., Hollander, E., Aronson, A., and Siever, L. (1996). A 23-year-old woman with panic disorder treated with psychoanalytic psychotherapy. American Journal of Psychiatry, 153, 698-703.
75. Mosher, L., and Burti, L. (1989). Community mental health. New York: W.W. Norton and Co.
76. Pam, A. (1990). A critique of the scientific status of biological psychiatry. Acta Psychiatrica Scandinavica, 82 (Supplement 362), 1-35.
77. Polymeropoulos, M.H., Higgins, J.J., Globe, L.I., Johnson, W.G., Ide, S.E., DiLori, G., Sanges, G., Stenroos, E.S., Pho, L.T., Schaffer, A.A., Lazzarinin, A.M., Nussbaum, R.L., and Duvoisin, R.C. (1996). Mapping of a gene for Parkinson's Disease to chromosome 4q21-q23. Science, 274, 1197-1199.
78. Porter, R.J. (1992). Conflict of interest in research. In R.J. Porter and T.E. Malone (Eds.), Biomedical research: Collaboration and conflict of interest (pp. 121-162). Baltimore: The Johns Hopkins University Press.
79. Prien, R.F., and Levine, J. (1984). Research and methodological issues for evaluating the therapeutic effectiveness of antidepressant drugs. Psychopharmacology Bulletin, 10, 250-257.
80. Raskis, H.A., and Smarr, I.R. (1957). Psychopharmacotherapeutic research. A.M.A. Archives of Neurology and Psychiatry, 2, 202-209.
81. Robins, E., and Guze, S.B. (1970). Establishment of diagnostic validity in psychiatric illness: Its application to schizophrenia. American Journal of Psychiatry, 126, 107-111.
82. Rodin, G., and Voshart, K. (1986). Depression in the medically ill: An overview. American Journal of Psychiatry, 143, 696-705.
83. Ross, C.A. (1986). Biological tests for mental illness: Their use and misuse. Biological Psychiatry, 21, 431-435.
84. Ross, C.A. (1995). Errors in logic in biological psychiatry. In C.A. Ross and A. Pam (Eds.), Pseudoscience in biological psychiatry (pp. 85-128). New York: John Wiley and Sons, Inc.
85. Rutter, M. (1983). Behavioral studies: Questions and findings on the concept of a distinctive syndrome. In M. Rutter (Ed.), Developmental neuropsychiatry (pp. 259-279). New York: Guilford Press.
86. Sachs, O. (1987). The man who mistook his wife for a hat. New York: Harper and Row.
87. Sarbin, T.R. (1990). Toward the obsolescence of the schizophrenia hypothesis. The Journal of Mind and Behavior, 11, 259-284.
88. Schou, M. (1968). Lithium in psychiatric therapy and prophylaxis. Journal of Psychiatric Research, 6, 67-95.
89. Shea, M.T., Elkin, I., Imber, S.D., Sotsky, S.M., Watkins, J.T., Collins, J.F., Pilkonis, P.A., Beckham, E., Glass, D.R., Dolan, R.T., and Perloff, M.B. (1992). Course of depressive symptoms over follow-up: Findings from the NIMH treatment of depression collaborative research program. Archives of General Psychiatry, 49, 782-787.
90. Shear, K.M., Cooper, A.M., Klerman, G.L., Busch, F.N., and Shapiro, T. (1993). A psychodynamic model of panic disorder. American Journal of Psychiatry, 150, 859-866.
91. Shear, K.M., and Fyer, M.F. (1988). Biological and psychopathological findings in panic disorder. In A.J. Frances and R.E. Hales (Eds.), Review of psychiatry, Volume 7 (pp. 29-53). Washington, D.C.: American Psychiatric Press.
92. Smith, A., Traganza, E., and Harrison, G. (1969). Studies on the effectiveness of antidepressant drugs. Psychopharmacology Bulletin, 5, 1-53.
93. Strauss, J.S. (1986). Psychiatric disorders: A reconsideration based on longitudinal processes. In T. Millon and G.L. Klerman (Eds.), Contemporary directions in psychopathology: Towards the DSM-IV (pp. 257-263). New York: The Guilford Press.
94. Strauss, J.S. (1992). The person - key to understanding mental illness: Towards a new dynamic psychiatry, III. British Journal of Psychiatry, 161 (Supplement 18), 19-26.
95. Strauss, J.S., Gabriel, R.K., Kokes, R.F., Ritzler, B.A., VanOrd, A., and Tarana, E. (1979). Do psychiatric patients fit their diagnoses? The Journal of Nervous and Mental Disease, 167, 105-113.
96. Strauss, J.S., Hafez, H., Leiberman, P., and Harding, C.M. (1985). The course of psychiatric disorder III: Longitudinal principles. American Journal of Psychiatry, 142, 289-296.
97. Strub, R.L., and Black, F.W. (1985). The mental status examination in neurology. Philadelphia: F.A. Davis Company.
98. Stuss, D.T., and Benson, D.F. (1986). The frontal lobes. New York: Raven Press.
99. Summerfield, A. (1978). Behavioral toxicity - The psychology of pollution. Journal of Biosocial Science, 10, 335-345.
100. Taylor, R.L. (1982). Mind or body. New York: McGraw-Hill.
101. Teicher, M.H., Glod, C., and Cole, J.O. (1990). Emergence of suicidal preoccupation during fluoxetine treatment. American Journal of Psychiatry, 147, 207-210.
102. Teicher, M.H., Glod, C., and Cole, J.O. (1993). Antidepressant drugs and the emergence of suicidal tendencies. Drug Safety, 8, 186-212.
103. Terr, L.C. (1991). Childhood traumas: An outline and overview. American Journal of Psychiatry, 148, 10-20.
104. Thomson, R. (1982). Side effects and placebo amplification. British Journal of Psychiatry, 140, 64-68.
105. Vaillant, G.E. (1984). The disadvantages of DSM-III outweigh its advantages. American Journal of Psychiatry, 141, 542-545.
106. Vaillant, G.E. (1988). What is a case? Archives of General Psychiatry, 45, 313-319.
107. Vaughn, C.E., and Leff, J.P. (1976). The influence of family and social factors on the course of psychiatric illness. British Journal of Psychiatry, 129, 126-137.
108. Vega, W.A., and Murphy, J.W. (1990). Culture and the restructuring of community mental health. New York: Greenwood Press.
109. Wallerstein, R.S. (1986). Forty-two lives in treatment. New York: The Guilford Press.
110. Warnes, H. (1982). Physical illness in the psychiatric patient. In E.K. Korany (Ed.), Physical illness in the psychiatric patient (pp. 119-142). Springfield, Illinois: Charles C. Thomas, Publisher.
111. Weissman, M.M., and Klerman, G.L. (1980) Debate on psychiatric epidemiology. In reply [to L. Srole and A.K. Fisher]. Archives of General Psychiatry, 37, 1423-1424.
112. Wetzler, S., and van Pragg, H.M. (1989). Assessment of depression. In S. Wetzler (Ed.), Measuring mental illness (pp. 71-89). Washington, D.C.: American Psychiatric Press, Inc.
113. Widiger, T.A., and Shea, T. (1991). Differentiation of Axis I and Axis II disorders. Journal of Abnormal Psychology, 100, 399-406.
114. Wilson, M. (1993). DSM-III and the transformation of American psychiatry: A history. American Journal of Psychiatry, 150, 399-410.
115. Wing, J.K. (1987). The long-term social adaptation in schizophrenia. In N.E. Miller and G.D. Cohen (Eds.), Schizophrenia and aging (pp. 183-188). New York: The Guilford Press.
116. Zinberg, N.E. (1976). Observations on the phenomenology of consciousness change. Journal of Psychedelic Drugs, 8, 59-76.