The bicyclo[3.2.0]heptan-endo-2-ol and bicycle[3.2.0]hept-3-en-6-one approaches in the synthesis of grandisol: The evolution of an idea and efforts to improve versatility and practicality

Organic Process Research and Development

Volumn 3, Issue 3, 1999, Pages 206-219

  Marotta, Emanuela ^a   Righi, Paolo ^a   Rosini, Goffredo ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0033453676     PISSN: 10836160     EISSN: None     Source Type: Journal    
DOI: 10.1021/op9800663     Document Type: Article

References (2)

1. It is interesting that the trans isomer is also a natural product that was later isolated from the roots of Artemisia fragrans Willd and termed fragrantol (Bohlmann, F.; Zdero, C; Faass, U. Chem. Ber. 1973,106,29042909). The Irans isomer was found to be 100- to 200-fold less active than the cis in the laboratory assay of weevil attraction (see: Martin, T.; Rodriguez, M.; Martin, V. S. Tetrahedron: Asymmetry 1995, 6, 11511164)
2. It is interesting that the trans isomer is also a natural product that was later isolated from the roots of Artemisia fragrans Willd and termed fragrantol (Bohlmann, F.; Zdero, C; Faass, U. Chem. Ber. 1973,106,29042909). The Irans isomer was found to be 100- to 200-fold less active than the cis in the laboratory assay of weevil attraction (see: Martin, T.; Rodriguez, M.; Martin, V. S. Tetrahedron: Asymmetry 1995, 6, 11511164)