Investigations on the synthesis and pharmacological properties of amides of 7-methyl-3-phenyl-1-[2-hydroxy-3-(4-phenyl-1-piperazinyl)propyl]-2,4- dioxo-1,2,3,4-tetra-hydropyrido[2,3-d]pyrimidine-5-carboxylic acid

Farmaco

Volumn 54, Issue 11-12, 1999, Pages 773-779

  Śladowska, Helena ^a   Sieklucka Dziuba, Maria ^b   Rajtar, Grazyna ^b   Sadowski, Miroslaw ^b   Kleinrok, Zdzislaw ^b  

^a WROCLAW MEDICAL UNIVERSITY   (Poland)

^b MEDICAL UNIVERSITY OF LUBLIN   (Poland)

Author keywords

Amides; N 2 Hydroxy 3(4 phenyl 1 piperazinyl)propyl derivatives; Pharmacological activity; Pyrido 2,3 d pyrimidines; Synthesis

Indexed keywords

7 METHYL 3 PHENYL 1 [2 HYDROXY 3 (4 PHENYL 1 PIPERAZINYL)PROPYL] 2,4 DIOXO 1,2,3,4 TETRAHYDROPYRIDO[2,3 D]PYRIMIDINE 5 CARBOXYLIC ACID; AMIDE; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL MODEL; ARTERIAL PRESSURE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG STRUCTURE; DRUG SYNTHESIS; FEMALE; LOCOMOTION; MALE; NEUROTOXICITY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHYSICAL CHEMISTRY; RAT; TOXICITY TESTING; TRANQUILIZING ACTIVITY;

AMIDES; ANALGESICS, NON-NARCOTIC; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; LETHAL DOSE 50; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MICE; MOLECULAR STRUCTURE; PYRIDINES; PYRIMIDINONES; RATS; RATS, WISTAR;

EID: 0033436361     PISSN: 0014827X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-827X(99)00101-9     Document Type: Article

References (14)

1. Śladowska H. Investigations on the synthesis and properties of arylpiperazinylalkyl derivatives of some dihydro- and tetrahydropyrido[2,3-d]pyrimidines. Farmaco. 48:1993;77-84.
2. Śladowska H., Bartoszko-Malik A., Zawisza T. Investigations on the reaction course of diethyl 2-chloro-6-methylpipridine-3,5-dicarboxylate with N-amino and N-hydroxyalkyl derivatives of thiourea. Farmaco. 41:1986;899-912.
3. Śladowska H., Bartoszko-Malik A., Zawisza T. Synthesis and properties of the derivatives of 2-alkylthio-4-oxo-3,4 (and 1,4)-dihydropyrido[2,3-d]pyridmide-5- and -6-carboxylic acids. Farmaco. 45:1990;111-121.
4. Śladowska H., Sieklucka-Dziuba M., Staniak L., Kleinrok Z. Synthesis and properties of l-aryl(pyrimidinyl)piperazinylalkyl derivatives of ethyl 3-phenyl-7-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-5- carboxylate. Farmaco. 49:1994;499-503.
5. H. Śladowska, J. Potoczek, M. Sieklucka-Dziuba, G. Rajtar, Z. Kleinrok, in press.
6. Śladowska H., Bartoszko-Malik A., Zawisza T. Synthesis and properties of new derivatives of ethyl 7-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-5-carboxylate. Farmaco. 45:1990;101-110.
7. Litchfield I.T., Wilcoxon F. A simplified method of evaluating dose-effect experiments. J. Pharmacol. Exp. Ther. 96:1949;99-113.
8. Gross F., Tripod J., Meier R. Zur pharmakologischen Charakterisierung des Schlafmittels Doriden. Med. Wschr. 85:1995;305-309.
9. Koster R., Anderson M., de Bear J.E. Acetic acid for analgesic screening. Fed. Proc. Fed. Am. Soc. Exp. Biol. 18:1959;412.
10. Eddy N.B., Leimbach D. Synthetic analgesics, II. Dithienyl-butenyl and dithienyl-butylamines. J. Pharmacol. Exp. Ther. 107:1953;385-389.
11. Aron C., Simon D., Larousse C., Bīssier J.R. Evaluation of a rapid technique for detecting minor tranquilizers. Neuropharmacology. 10:1971;459-469.
12. Swinyard E.A., Brown W.C., Goodman L.S. Comparative assays of antiepileptic drugs in mice and rats. J. Pharmacol. Exp. Ther. 106:1952;319-330.
13. Nakamura M., Fukushima H. Effects of reserpine, parachlorophenylalanine, 5,6-dihydroxytryptamine and fludiazepam on the head twitches induced by 5-hydroxytryptamine or 5-methoxytryptamine in mice. J. Pharm. Pharmacol. 30:1978;254-256.
14. Gerold M., Tschirky H. Measurement of blood pressure in unanaesthetized rats. Artzneim. Forsch. 18:1968;1285-1287.