Antagonistic interaction between the convulsant activities of pefloxacin and its main metabolite norfloxacin in rats

Pharmaceutical Research

Volumn 16, Issue 12, 1999, Pages 1894-1897

  Delon, Annie ^a   Levasseur, Laurence M ^b   Giraudon, Mylène ^a   Bouquet, Serge ^a   Couet, William ^a  

^a UPRES EA 1223   (France)

^b ROSWELL PARK CANCER INSTITUTE   (United States)

Author keywords

Combination index; Fluoroquinolones; Metabolites; Pharmacodynamics; Seizures

Indexed keywords

DRUG METABOLITE; NORFLOXACIN; PEFLOXACIN;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CONVULSION; DOSE RESPONSE; DRUG ACTIVITY; DRUG ANTAGONISM; DRUG CEREBROSPINAL FLUID LEVEL; DRUG POTENCY; MALE; NONHUMAN; PHARMACODYNAMICS; PRIORITY JOURNAL; RAT;

ALGORITHMS; ANIMALS; ANTI-INFECTIVE AGENTS; CONVULSANTS; DRUG INTERACTIONS; MALE; MODELS, BIOLOGICAL; NORFLOXACIN; PEFLOXACIN; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0033428350     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1011967813140     Document Type: Article

References (14)

1. M. Danhof and G. Levy. Kinetics of drug action in disease states. I. Effect of infusion rate on phenobarbital concentrations in serum, brain and cerebrospinal fluid of normal rats at onset of loss of righting reflex. J. Pharmacol. Exp. Ther. 229:44-50 (1984).
2. A. Delon, F. Huguet, P. Courtois, J. M. Vierfond, S. Bouquet, and W. Couet. Pharmacokinetic-Pharmacodynamic contributions to the convulsant activity of pefloxacin and norfloxacin in rats. J. Pharmacol. Exp. Ther. 280:983-987 (1997).
3. W. Christ. Central nervous system toxicity of quinolones: human and animal findings. J. Antimicrob. Chemother. 26 (Suppl.B):219-225 (1990).
4. A. Delon, C. Pariat, P. Courtois, S. Bouquet, and W. Couet. A new approach for early assessment of the epileptogenic potential of qoinolones. Antimicrob. Agents Chemother. 42:2756-2758 (1998).
5. A. Delon, S. Bouquet, F. Huguet, V. Brunet, P. Courtois, and W. Couet. Pharmacokinetic-Pharmacodynamic contributions to the convulsant activity of fluoroquinolones in rats. Antimicrob. Agents Chemother. 43:1511-1515 (1999).
6. P. M. Klockowski and G. Levy. Kinetics of drug action in disease states. XXIV. Pharmacodynamics of diazepam and its active metabolites in rats. J. Pharmacol. Exp. Ther. 244:912-918 (1987).
7. L. M. Levasseur, A. Delon, W. R. Greco, P. Faury, S. Bouquet, and W. Couet. Development of a new quantitative approach for the isobolographic assessment of the convulsant interaction between pefloxacin and theophylline in rats. Pharm. Res. 15:1069-1076 (1998).
8. G. Montay, Y. Goueffon, and F. Roquet. Absorption, distribution, metabolic fate, and elimination of pefloxacin mesylate in mice, rats, dogs, monkey and humans. Antimicrob. Agents Chemother. 25:463-472 (1984).
9. U. Jaehde, M. W. E. Langemeijer, A. G. de Boer and D. D. Breimer. Cerebrospinal fluid transport and disposition of the quinolones ciprofloxacin and pefloxacin in rats. J. Pharmacol. Exp. Ther. 263:1140-1146 (1992).
10. W. R. Greco, G. Bravo, and J. C. Parsons. The search for synergy: a critical review from a response surface perspective. Pharmacol. Rev. 47:331-385 (1995).
11. W. R. Greco, H. S. Park, and Y. M. Rustum. Application of a new approach for the quantitation of drug synergism to the combination of cis-diamminedichloroplatinum and 1-beta-D-ara-binofuranosylcytosine. Cancer Res. 50(17):5318-27 (1990).
12. S. Loewe and H. Muischnek. Effect of combinations: mathematical basis of problem. Arch. Exp. Pathol. Pharmakol. 114:313-326 (1926).
13. M. C. Berenbaum. The expected effect of a combination of agents: the general solution. J. Theor. Biol. 114:413-431 (1985).
14. J. Zhi and G. Levy. Isobolographic assessment of the convulsant interaction between theophylline and caffeine or pentylenetetrazol in rats. J. Pharm. Sci. 79:678-681 (1990).