Rational development of cell-penetrating high affinity SH3 domain binding peptides that selectively disrupt the signal transduction of Crk family adapters

Annals of the New York Academy of Sciences

Volumn 886, Issue , 1999, Pages 289-292

  Kardinal, Christian ^a   Posern, Guido ^a   Zheng, Jie ^b   Knudsen, Beatrice S ^c   Moarefi, Ismail ^d   Feller, Stephan M ^a,e  

^a UNIVERSITY OF WÜRZBURG   (Germany)

^b Division of Virology Department of Infectious Diseases St Jude Children's Hospital   (United States)

^c NEW YORK PRESBYTERIAN HOSPITAL   (United States)

^d MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^e Laboratory of Molecular Oncology   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

PEPTIDE;

ANIMAL CELL; CELL MEMBRANE PERMEABILITY; CONFERENCE PAPER; CONTROLLED STUDY; DRUG PROTEIN BINDING; DRUG UPTAKE; NONHUMAN; ONCOGENE SRC; PROTEIN DOMAIN; PROTEIN FAMILY; RAT; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0033427343     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1999.tb09439.x     Document Type: Conference Paper

References (5)

1. 1. Feller, S.M. et al. 1998. Physiological signals and oncogenesis mediated through Crk family adapter proteins. J. Cell. Physiol. In press.
2. 2. Wu, X. et al. 1995. Structural basis for the specific interaction of lysine-containing proline-rich peptides with the N-terminal SH3 domain of c-Crk. Structure 3: 215-226.
3. 3. Knudsen, B.S. et al. 1995. Affinity and specificity requirements for the first Src homology 3 domain of the Crk proteins. EMBO J. 14: 2191-2198.
4. 4. Posern, G. et al. 1998. Development of highly selective SH3 binding peptides for Crk and CRKL which disrupt Crk-complexes with DOCK180, SoS and C3G. Oncogene 16: 1903-1912.
5. 5. Derossi, D. et al. 1998. Trojan peptides: The penetratin system for intracellular delivery. Trends Cell Biol. 8: 84-87.