Insulin replacement therapy for the rat model of streptozotocin-induced diabetes mellitus

Laboratory Animal Science

Volumn 49, Issue 6, 1999, Pages 639-644

  Haughton, Cheryl L ^a,b   Dillehay, Dirck L ^a   Phillips, Lawrence S ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HENRY FORD HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; INSULIN ZINC SUSPENSION; ISOPHANE INSULIN;

ANIMAL MODEL; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DIABETES MELLITUS; EXPERIMENTAL MODEL; GLUCOSE BLOOD LEVEL; INSULIN TREATMENT; MALE; NONHUMAN; RAT; STREPTOZOCIN DIABETES; TREATMENT OUTCOME;

ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; DIABETES MELLITUS, EXPERIMENTAL; HORMONE REPLACEMENT THERAPY; HYPOGLYCEMIA; INSULIN; MALE; RATS; RATS, SPRAGUE-DAWLEY; SPECIFIC PATHOGEN-FREE ORGANISMS;

EID: 0033427183     PISSN: 00236764     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Bell, R. H., and R. J. Hye. 1983. Animal models of diabetes mellitus: physiology and pathology. J. Surg. Res. 35:433-460.
2. Gavin, J. R. 1997. Special section on diabetes. Ebony LII: 115-122.
3. Mordes, J. P., and A. A. Rossini. 1981. Animal models of diabetes. Am. J. Med. 70:353-360.
4. Buschard, K. 1996. Diabetic animal models. APMIS 104: 609-614.
5. Chang, A. Y. 1978. Spontaneous diabetes in animals. Gen. Pharmacol. 9:447-450.
6. Bellush, L. L., and S. G. Reid. 1994. Metabolic and neurochemical profiles in insulin-treated diabetic rats. Am. J. Physiol. 266:R87-R94.
7. Thulesen, J., C. Orskon, J. Holst, et al. 1997. Short term insulin treatment prevents the diabetogenic action of streptozotocin in rats. Endocrinology 138:62-68.
8. Ar' Rajab A., and B. Ahren. 1993. Long-term diabetogenic effect of streptozotocin in rats. Pancreas 8:50-57.
9. Phillips, L. S., A. C. Fusco, and T. G. Unterman. 1985. Nutrition and somatomedin XIV. Altered levels of somatomedins and somatomedin inhibitors in rats with streptozotocin-induced diabetes. Metabolism 34:765-770.
10. Marks, J. L., K. Waite, and M. Li. 1993. Effects of streptozotocin-induced diabetes mellitus and insulin treatment on neuropeptide Y mRNA in the rat hypothalamus. Diabetologia 36:497-502.
11. Pugliese, G. R., G. Tilton, A. Speedy, et al. 1994. Effects of combined insulin and sorbinil treatment on diabetes-induced vascular dysfunction in rats. Metabolism 43:492-500.
12. Rubinstein, M. T., F. Schaible, A. Malhotra, et al. 1984. Effects of graded insulin therapy on cardiac function in diabetic rats. Am. J. Physiol. 246:H453-H458.
13. Ramanadham, D., P. Decker, and T. E. Tenner. 1983. Effect of insulin replacement on streptozotocin-induced effects in the rat heart. Life Sci. 33:289-296.
14. Shimomura, J., H. Shimizu, M. Takahasi, et al. 1990. Different effects of insulin administration time in streptozotocin-induced diabetic rats. Exp. Clin. Endocrinol. 96:296-300.
15. Durrington, P. N., and W. P. Stephens. 1980. The effects of treatment with insulin on serum high-density-lipoprotein cholesterol in rats with streptozotocin-induced diabetes. Clin. Sci. 59:71-74.
16. Longhurst, P. A., J. Kauer, and R. Levin. 1991. The ability of insulin treatment to reverse or prevent the changes in urinary bladder function caused by streptozotocin-induced diabetes mellitus. Gen. Pharmacol. 22:305-311.
17. Guillermo, U. E., and R. G. Spanheimer. 1988. The use of glucose oxidase reagent strips to determine the metabolic status of diabetic animals. Lab. Anim. Sci. 38:94-96.
18. Leahy, J. L., and G. C. Weir. 1988. Evolution of abnormal insulin secretory responses during 48 hour in vivo hyperglycemia. Diabetes 37:217-222.
19. Hollander, P. 1991. Premixed insulins. How do they compare with other insulin preparations? Postgrad. Med. 89:52-61.
20. Phillips, L. S., A. T. Orawski, and M. S. Chicago. 1977. Nutrition and somatomedin III. Diabetic control, somatomedin, and growth in rats. Diabetes 26:864-869.
21. Graubert, M. D., S. Goldstein, and L. S. Phillips. 1991. Nutrition and somatomedin XXVII. Total and free IGF-1 and IGF binding proteins in rats with streptozotocin-induced diabetes. Diabetes 40:959-965.
22. Pao, C., P. K. Farmer, S. Begovic, et al. 1992. Expression of hepatic insulin-like growth factor-binding protein-1 genes is transcriptionally regulated in streptozotocin-diabetic rats. Mol. Endocrinol. 6:969-977.
23. Pugliese, G., R. G. Tilton, A. Speedy, et al. 1994. Effects of combined insulin and sorbinil treatment on diabetes-induced vascular dysfunction in rats. Metabolism 43:492-500.
24. Longhurst, P. A., J. Kauer, and R. M. Levin. 1991. The ability of insulin treatment to reverse or prevent changes in urinary bladder function caused by streptozotocin-induced diabetes mellitus. Gen. Pharmacol. 22:305-311.
25. Rubinstein, M., T. F. Schaible, and A. Malhotra. 1984. Effects of graded insulin therapy on cardiac function in diabetic rats. Am. J. Physiol. 246:H453-H458.
26. The Diabetes Control and Complications Trial Research Group. 1993. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N. Engl. J. Med. 329:977-986.
27. Ohkubu, J., K. Hideki, A. Eiichi, et al. 1995. Intensive insulin therapy prevents the progression of diabetic microvascular complications in Japanese patients with non-insulin dependent diabetes mellitus: a randomized prospective 6-year study. Diabetes Res. Clin. Pract. 28:103-117.