Synthetic process development of antitumor agent KT6587, an indolocarbazole alkaloid K252a derivative

Organic Process Research and Development

Volumn 3, Issue 2, 1999, Pages 131-134

  Kinugawa, Masahiko ^a   Mimura, Yukiteru ^a   Masuda, Yoshiaki ^a   Murakata, Chikara ^a   Ogasa, Takehiro ^a   Kasai, Masaji ^a  

^a KYOWA HAKKO KOGYO CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0033416478     PISSN: 10836160     EISSN: None     Source Type: Journal    
DOI: 10.1021/op980087x     Document Type: Article

References (5)

1. For the isolation of K252a, see: Kase, H.; Iwahashi, K.; Matsuda, Y. J. Antibiot. 1986, 39, 1059. For the synthesis of K252a, see: Wood, J. L.; Stoltz, B. M.; Dietrich, H.-J.; Pflum D. A.; Petsch, D. Y. J. Am. Chem. Soc. 1997, 119, 9641 and references cited therein.
2. For the isolation of K252a, see: Kase, H.; Iwahashi, K.; Matsuda, Y. J. Antibiot. 1986, 39, 1059. For the synthesis of K252a, see: Wood, J. L.; Stoltz, B. M.; Dietrich, H.-J.; Pflum D. A.; Petsch, D. Y. J. Am. Chem. Soc. 1997, 119, 9641 and references cited therein.
3. Berg, M. M.; Sternberg, D. W.; Parada, L. F.; Chao, M. V. J. Biol. Chem. 1992, 267, 13.
4. Nye, S. H.; Squinto, S. P.; Glass, D. J.; Stitt, T. N.; Hantzopoulos, P.; Macchi, M. J.; Lindsay, N. S.; Ip, N. Y.; Yancopoulos, G. Mol. Biol. Cell 1992, 3, 677.
5. Ohmichi, M.; Decker, S. J.; Pang, L.; Saltiel, A. R. Biochemistry 1992, 31, 4034.