Enzymatic resolution of (±)-conduritol-B, a key intermediate for the synthesis of glycosidase inhibitors

Tetrahedron Asymmetry

Volumn 10, Issue 17, 1999, Pages 3273-3276

  Sanfilippo, Claudia ^a   Patti, Angela ^a   Nicolosi, Giovanni ^a  

^a CNR   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CONDURITOL B; GLYCOSIDASE INHIBITOR; PANCREAS ENZYME; POLYOL; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL STRUCTURE; CHIRALITY; ENANTIOMER; ENZYME INHIBITION; NONHUMAN; PANCREAS; PRIORITY JOURNAL; SWINE; SYNTHESIS;

EID: 0033406670     PISSN: 09574166     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0957-4166(99)00344-4     Document Type: Article

References (15)

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7. Enantiomeric excesses (ee) were determined by GC analysis on chiral capillary column (Megadex DMP β, dimethylpenthyl β-CDX, OV1701 0.25 μm×0.25 mm×25 m). The ee of tetracetylconduritol-B was determined by direct injection. After conventional acetylation, the same method was utilised for excess determinations of (-)-2 and (-)-3.
8. For comparison of the alcoholysis of the conduritol-E tetraacetate see: Ref. 4a.
9. 3): δ 22.2, 72.2, 76.8, 130.4, 172.7.
10. 3 for the R enantiomer).
11. Le Drian, C.; Vionnet, J.-P.; Vogel, P. Helv. Chim. Acta 1990, 73, 161-168.
12. 3): δ 21.9, 22.1, 22.2, 72.0, 72.5, 73.1, 76.9, 126.8, 132.4, 171.4, 171.6, 172.7.
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