Synthesis and pharmacological activity of 4-amino-5-chloro-2-methoxy-N- [(2S,4S)-1-ethyl-2-hydroxymethyl-4-pyrrolidinyl]benzamide (TKS159) and its optical isomers

Chemical and Pharmaceutical Bulletin

Volumn 47, Issue 11, 1999, Pages 1650-1654

  Yanagi, Toshiharu ^a,b   Kitajima, Akihiko ^a   Anzai, Kinsei ^a   Kodama, Kazuya ^a   Mizoguchi, Jun Ichi ^a   Fujiwara, Hiromichi ^a   Sakiyama, Hideyo ^a   Kamoda, Osamu ^a   Kamei, Chiaki ^b  

^a Teikoku Chem Industries Co Ltd   (Japan)

^b OKAYAMA UNIVERSITY   (Japan)

Author keywords

4 amino 5 chloro 2 methoxy N (2S,4S) 1 ethyl 2 hydroxymethyl 4 pyrrolidinyl benzamide; Gastric emptying; Gastroprokinetic activity; Optically active; Serotonin 5 HT4 receptor

Indexed keywords

4 AMINO 5 CHLORO N (1 ETHYL 2 HYDROXYMETHYL 4 PYRROLIDINYL) 2 METHOXYBENZAMIDE; 4 AMINO 5 CHLORO N [(HEXAHYDRO 1H PYRROLIZIN 1 YL)METHYL] 2 METHOXYBENZAMIDE; BENZAMIDE DERIVATIVE; MOSAPRIDE CITRATE; PROKINETIC AGENT; PYRROLIDINE DERIVATIVE; SEROTONIN 4 RECEPTOR; UNCLASSIFIED DRUG; ZACOPRIDE;

ANIMAL EXPERIMENT; ARTICLE; CHEMICAL REACTION; CHIRALITY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; HYDROGEN BOND; MALE; NONHUMAN; RAT; REACTION ANALYSIS; STEREOCHEMISTRY; STOMACH EMPTYING; STRUCTURE ACTIVITY RELATION; SWINE;

EID: 0033405674     PISSN: 00092363     EISSN: None     Source Type: Journal    
DOI: 10.1248/cpb.47.1650     Document Type: Article

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