Evidence from a Ghanaian population of known African descent to support the proposition that hemochromatosis is a Caucasian disorder

Genetic Testing

Volumn 3, Issue 4, 1999, Pages 375-377

  Jeffery, S ^a   Crosby, A ^a   Plange Rhule, J ^b   Amoah Danquah, J ^b   Acheampong, J W ^b   Eastwood, J B ^a   Saggar Malik, A K ^a  

^a ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^b KWAME NKRUMAH UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Ghana)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; CHROMOSOME 6; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENE MUTATION; GENETIC RISK; GENOTYPE; GHANA; HEMOCHROMATOSIS; HUMAN; MALE; NORMAL HUMAN;

EID: 0033404970     PISSN: 10906576     EISSN: None     Source Type: Journal    
DOI: 10.1089/gte.1999.3.375     Document Type: Article

References (12)

1. ADAMS, P.C., DEUGNEER, Y., MOIRAND, R., and BRISSOT, P. (1997). The relationship between iron overload, clinical symptoms, and age in 410 patients with genetic haemochromatosis. Hepatology 25, 162-166.
2. BULAJ, Z.J., GRIFFEN, L.M., JORDE, L.B., EDWARDS, C.Q., and KUSHNER, J.P. (1996). Clinical and biochemical abnormalities in people heterozygous for hemochromatosis. New Engl. J. Med. 335, 1799-1805.
3. CULLEN, L.M., GAO, X., EASTEAL, S., JAZWINSKA, E.C. (1998). The hemochromatosis 845 G → A and 187 C → G mutations: prevalence in non-caucasian populations. Am. J. Hum. Genet. 62, 1403-1407.
4. FEDER, J.N., GNIRKE, A., THOMAS, W., et al. (1996). A novel MHC classl-like gene is mutated in patients with hereditary haemochromatosis. Nature Genet. 13, 399-408.
5. GEORGE, D.K., and POWELL, L.W. (1997). Review article: the screening, diagnosis and optimal management of haemochromatosis. Aliment. Pharmacol. Ther. 11, 631-639.
6. JAWINSKA, E.C., LEE, S.C., WEBB, S.I., HALLIDAY, J.W., and POWELL, L.W. (1993). Localisation of the haemochromatosis gene close to D6S105. Am. J. Hum. Genet. 53, 347-352.
7. MERRYWEATHER-CLARKE, A.T., POINTON, J.J., SHEARMAN, J.D., and ROBSON, K.J.H. (1997). Global prevalence of putative haemochromatosis mutations. J. Med. Genet. 34, 275-278.
8. MULLIGHAN, C.G., BUNCE, M., FANNING, G.C., MARSHALL, S.E., and WELSH, K.I. (1998). A rapid method of haplotyping HFE mutations and linkage disequilibrium in a caucasoid population. Gut 42, 566-569.
9. RISCH, N. (1997). Haemochromatosis, HFE and genetic complexity. Nature Genetics 17, 375-376.
10. ROTH, M., GIRALDO, P., HARITI, G., POLONI, E.S., SANCHEZ-MAZAS, A., STEFANO, G.F.D., DUGOUJON, J.M., and COPPIN, H. (1997). Absence of the hemochromatosis gene Cys282Tyr mutation in three ethnic groups from Algeria (Mzab), Ethiopia and Senegal. Immunogenetics 46, 222-225.
11. SIMON, M., BOUREL, M., FAUCHET, R., and GENETET, B. (1976). Association of HLA-A3 and HLA-B14 antigens with idiopathic haemochromatosis. Gut 17, 332-334.
12. YAOUANG, J., PERICHON, M., CHORNEY, M., et al. (1994). Anonymous marker loci within 400 kb of HLA-A generate haplotypes in linkage disequilibrium with the hemochromatosis gene (HFE). Am. J. Hum. Genet. 54, 252-263.