Diclazuril in the horse: Its identification and detection and preliminary pharmacokinetics

Journal of Veterinary Pharmacology and Therapeutics

Volumn 22, Issue 6, 1999, Pages 374-379

  Dirikolu, L ^a   Lehner, F ^a   Nattrass, C ^b   Bentz, B G ^a   Woods, W E ^a   Carter, W G ^a   Karpiesiuk, W ^a   Jacobs, J ^a   Boyles, J ^a   Harkins, J D ^a   Granstrom, D E ^a   Tobin, T ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

^b Truesdail Laboratories   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIPROTOZOAL AGENT; DICLAZURIL;

ANIMAL EXPERIMENT; ARTICLE; COCCIDIOSIS; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG CEREBROSPINAL FLUID LEVEL; DRUG HALF LIFE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HORSE; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; THIN LAYER CHROMATOGRAPHY;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COCCIDIOSTATS; FEMALE; HORSES; MASS SPECTROMETRY; NITRILES; TRIAZINES;

ANIMALIA; EQUIDAE; EQUUS CABALLUS; SARCOCYSTIS NEURONA;

EID: 0033404685     PISSN: 01407783     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2885.1999.00232.x     Document Type: Article

References (7)

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2. Granstrom, E.D., McCrillis, S., Wulff-Strobel, C., Baker, B.C., Carter, W.G., Harkins, D.J., Tobin, T., Saville, J.W. et al. (1997) A clinical report of diclazuril treatment for equine protozoal myeloencephalitis. Proceedings of the Annual Meeting of the American Association of Equine Practitioners. (Abstract) pp. 13-14.
3. Hackstein, P.H., Meijerink, P.P.J., Schubert, H., Leunissen, M.A.J., Mehlhorn, N., Mackenstedt, U. et al. (1995) Parasitic apicomplexans harbor a chlorophyll a-D1 complex, the potential target for therapeutic triazines. Parasitology Research, 81, 207-216.
4. Kock, D.J., Smet, D.M., Sneyers, R. (1992) Determination of diclazuril in animal feed by liquid chromatography. Journal of Chromatography, 606, 141-146.
5. Kohler, S., Delwiche, C.F., Denny, P.W., Tilney, L.G., Webster, P., Wilson, R.J., Palmer, J.D., Roos, D.S. et al. (1997) A plastid of probable green algal origin in Apicomplexan parasites. Science, 275, 1485-1489.
6. Lindsay, S.D., Rippey, S.N., Toivio-Kinnucan, M.A., Blagburn, L.B. et al. (1995) Ultrastructural effects of diclazuril against Toxoplasma Gondii and investigation of a diclazuril-resistant mutant. Journal of Parasitology. 81, 459-466.
7. Lindsay, S.D. & Dubey, P.J. (1999) Determination of the activity of diclazuril against Sarcocystis neurona and Sarcocystis falcatula in cell cultures. Journal of Parasitology (in press).