Ketanserin inhibits digoxin-induced arrhythmias in the anaesthetized guinea-pig

Fundamental and Clinical Pharmacology

Volumn 13, Issue 6, 1999, Pages 646-649

  Kalyoncu, Nuri Ihsan ^a   Ozyavuz, Rasin ^a  

^a KARADENIZ TECHNICAL UNIVERSITY   (Turkey)

Author keywords

Arrhythmia; Digoxin; Guinea pig; Ketanserin

Indexed keywords

DIGOXIN; KETANSERIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL PRESSURE; ARTICLE; CAROTID ARTERY; CONTROLLED STUDY; DOSE RESPONSE; ELECTROCARDIOGRAM; FEMALE; GUINEA PIG; HEART ARRHYTHMIA; MALE; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL;

EID: 0033403396     PISSN: 07673981     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1472-8206.1999.tb00375.x     Document Type: Article

References (14)

1. + channel in mammalian cardiac cells, Nature 309 (1984) 354-356.
2. + channels in guinea-pig ventricular cells, Br. J. Pharmacol. 119 (1996) 133-141.
3. [3] Kukushkin N.I., Gainulin R.Z., Sosunov E.A., Transient outward current and rate dependence of action potential duration in rabbit cardiac ventricular muscle, Pflugers Arch. 399 (1983) 87-92.
4. [4] Le Grand B., Talmant J.M., Rieu J.P., Patoiseau J.F., Colpacrt F.C., John G.W., Investigation of the mechanism by which ketanserin prolongs the duration of the cardiac action potential, J. Cardiovasc. Pharmacol. 26 (1995) 803-809.
5. [5] Zhang Z.-H., Boutjdir M., El-Sherif N., Ketanserin inhibits depolarization-activated outward potassium current in rat ventricular myocytes, Circ. Res. 75 (1994) 711-721.
6. [6] MacLeod B.A., Augereau P., Walker M.J.A., Effects of halothane anesthesia compared with fentanyl anesthesia and no anesthesia during coronary ligation in rats, Anesthesiology 58 (1983) 44-52.
7. [7] Roden D.M., Antiarrhythmic drugs, in: Hardman J.M., Limbird L.E., Molinoff P.B., Ruddon R.W., Gilman Goodman A. (Eds.), Goodman and Gilman's The Pharmacological Basis of Therapeutics, The McGraw-Hill Companies, New York, 1996, pp. 839-874.
8. [8] Rees S., Curtis M.J., Which cardiac potassium channel subtype is the preferable target for suppression of ventricular arrhythmias?, Pharmacol. Ther. 69 (1996) 199-217.
9. + channel current in ischaemic arrhythmias, Cardiovasc. Drugs Ther. 7 (suppl. 7) (1993) 521-526.
10. + channel in guinea-pig ventricular cardiomyocytes, Gen. Pharmacol. 27 (1996) 625-627.
11. [11] Saman S., Thandroyen F., Opie L.H., Serotonin and the heart: effects of ketanserin on myocardial function, heart rate, and arrhythmias, J. Cardiovasc. Pharmacol. 7 (suppl. 7) (1985) S70-75.
12. [12] Kamiya K., Venkatesh N., Singh B.N., Acute and chronic effects of ketanserin on the electrophysiological properties of isolated rabbit ventricular myocardium: particular reference to repolarization, Am. Heart J. 115 (1998) 1222-1228.
13. [13] Tatsuno-Atoda H., Shigenobu K., Cardiac effects of ketanserin, a serotonin antagonist-electrophysiological examinations as a part of toxicity studies, J. Toxicol. Sci. 13 (1988) 7-16.
14. [14] Coker S.J., Ellis A.M., Ketanserin and ritanserin can reduce reperfusion-induced but not ischaemia-induced arrhythmias in anaesthetised rats, J. Cardiovasc. Pharmacol. 10 (1987) 479-484.