A TrkB/insulin receptor-related receptor chimeric receptor induces PC12 cell differentiation and exhibits prolonged activation of mitogen-activated protein kinase

Cell Growth and Differentiation

Volumn 10, Issue 12, 1999, Pages 805-812

  Kelly Spratt, Karen S ^a   Klesse, Laura J ^a   Merenmies, Jussi ^a   Parada, Luis F ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; INSULIN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION;

ANIMALS; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL DIFFERENTIATION; ENZYME ACTIVATION; KINETICS; MITOGEN-ACTIVATED PROTEIN KINASES; PC12 CELLS; RATS; RECEPTOR, INSULIN; RECEPTOR, TRKB; RECOMBINANT FUSION PROTEINS; SUBSTRATE SPECIFICITY; TYROSINE;

ANIMALIA;

EID: 0033403194     PISSN: 10449523     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Shier, P., and Watt, V. Primary structure of a putative receptor for a ligand of the insulin family. J. Biol. Chem., 264: 14605-14608, 1989.
2. Zhang, B., and Roth, R. A. The insulin receptor-related receptor. Tissue expression, ligand binding specificity, and signaling capabilities. J. Biol. Chem., 267: 18320-18328, 1992.
3. Jui, H. Y., Suzuki, Y., Accili, D., and Taylor, S. I. Expression of a cDNA encoding the human insulin receptor-related receptor. J. Biol. Chem., 269: 22446-22452, 1994.
4. Reinhardt, R. R., Chin, E., Zhang, B., Roth, R. A., and Bondy, C. A. Selective coexpression of insulin receptor-related receptor (IRR) and TRK in NGF-sensitive neurons. J. Neurosci., 14: 4674-4683, 1994.
5. Myers, M. G., Jr., Grammer, T. C., Wang, L. M., Sun, X. J., Pierce, J. H., Blenis, J., and White, M. F. Insulin receptor substrate-1 mediates phosphatidylmositol 3′-kinase and p70S6k signaling during insulin, insulin-like growth factor-1, and interleukin-4 stimulation. J. Biol. Chem., 269: 28783-28789, 1994.
6. Kovacina, K. S., and Roth, R. A. Identification of SHC as a substrate of the insulin receptor kinase distinct from the GAP-associated 62 kDa tyrosine phosphoprotein. Biochem. Biophys. Res. Commun., 192: 1303-1311, 1993.
7. Rozakis-Adcock, M., McGlade, J., Mbamalu, G., Pelicci, G., Daly, R., Li, W., Batzer, A., Thomas, S., Brugge, J., Pelicci, P. G., at al. Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases. Nature (Lond.), 360: 689-692, 1992.
8. Kurachi, H., Jobo, K., Ohta, M., Kawasaki, T., and Itoh, N. A new member of the insulin receptor family, insulin receptor-related receptor, is expressed preferentially in the kidney. Biochem. Biophys. Res. Commun., 187: 934-939, 1992.
9. Reinhardt, R. R., Chin, E., Zhang, B., Roth, R. A., and Bondy, C. A. Insulin receptor-related receptor messenger ribonucleic acid is focally expressed in sympathetic and sensory neurons and renal distal tubule cells. Endocrinology, 133: 3-10, 1993.
10. Bates, C., Merenmies, J. M., Kelly-Spratt, K. S., and Parada, L. F. Insulin receptor-related receptor expression in non-A intercalated cells in the kidney. Kidney Int., 51: 674-681, 1997.
11. Greene, L. A., and Tischler, A. S. Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc. Natl. Acad. Sci. USA, 73: 2424-2428, 1976.
12. Soppet, D., Escandon, E., Maragos, J., Middlemas, D. S., Reid, S. W., Blair, J., Burton, L. E., Stanton, B. R., Kaplan, D. R., Hunter, T., et al. The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor. Cell, 65: 895-903, 1991.
13. Schechter, A. L., and Bothwell, M. A. Nerve growth factor receptors on PC12 cells: evidence for two receptor classes with differing cytoskeletal association. Cell, 24: 867-874, 1981.
14. Dahmer, M. K., and Perlman, R. L. Insulin and insulin-like growth factors stimulate deoxyribonucleic acid synthesis in PC12 pheochromocytoma cells. Endocrinology, 122: 2109-2113, 1988.
15. Kaplan, D. R., Martin-Zanca, D., and Parada, L. F. Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF. Nature (Lond.), 350: 158-160, 1991.
16. Traverse, S., Gomez, N., Paterson, H., Marshall, C., and Cohen, P. Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor. Biochem. J., 288: 351-355, 1992.
17. Sun, X. J., Wang, L. M., Zhang, Y., Yenush, L., Myers, M. G., Jr., Glasheen, E., Lane, W. S., Pierce, J. H., and White, M. F. Role of IRS-2 in insulin and cytokine signalling. Nature (Lond.), 377: 173-177, 1995.
18. Rabin, S. J., Cleghon, V., and Kaplan, D. R. SNT, a differentiation-specific target of neurotrophic factor-induced tyrosine kinase activity in neurons and PC12 cells. Mol. Cell. Biol., 13: 2203-2213, 1993.
19. Obermeier, A., Bradshaw, R. A., Seedorf, K., Choidas, A., Schlessinger, J., and Ullrich, A. Neuronal differentiation signals are controlled by nerve growth factor receptor/Trk binding sites for SHC and PLC γ. EMBO J., 13: 1585-1590, 1994.
20. Obermeier, A., Lammers, R., Wiesmuller, K. H., Jung, G., Schlessinger, J., and Ullrich, A. Identification of Trk binding sites for SHC and phosphatidylinositol 3′-kinase and formation of a multimeric signaling complex. J. Biol. Chem., 268: 22963-22966, 1993.
21. Stephens, R. M., Loeb, D. M., Copeland, T. D., Pawson, T., Greene, L. A., and Kaplan, D. R. Trk receptors use redundant signal transduction pathways involving SHC and PLC-γ1 to mediate NGF responses. Neuron, 12: 691-705, 1994.
22. Klesse, L. J., M. K. A., Marshall, C. J., and Parada, L. F. Nerve growth factor induces survival and differentiation through two distinct signaling cascades in PC12 cells. Oncogene, 18: 2055-2068, 1999.
23. Kaplan, D. R., and Stephens, R. M. Neurotrophin signal transduction by the Trk receptor. J. Neurobiol., 25: 1404-1417, 1994.
24. Van Obberghen, E. Signalling through the insulin receptor and the insulin-like growth factor-I receptor. Diabetologia, 37: S125-S134, 1994.
25. Kaburagi, Y., Momomura, K., Yamamoto-Honda, R., Tobe, K., Tamori, Y., Sakura, H., Akanuma, Y., Yazaki, Y., and Kadowaki, T. Site-directed mutagenesis of the juxtamembrane domain of the human insulin receptor. J. Biol. Chem., 268: 16610-16622, 1993.
26. Murakami, M. S., and Rosen, O. M. The role of insulin receptor autophosphorylation in signal transduction. J. Biol. Chem., 266: 22653-22660, 1991.
27. Chen, D., Van Horn, D. J., White, M. F., and Backer, J. M. Insulin receptor substrate 1 rescues insulin action in CHO cells expressing mutant insulin receptors that lack a juxtamembrane NPXY motif. Mol. Cell. Biol., 15: 4711-4717, 1995.
28. Pang, L., Milarski, K. L., Ohmichi, M., Takata, Y., Olefsky, J. M., and Saltiel, A. R. Mutation of the two carboxyl-terminal tyrosines in the insulin receptor results in enhanced activation of mitogen-activated protein kinase. J. Biol. Chem., 269: 10604-10608, 1994.
29. Dikic, I., Schlessinger, J., and Lax, I. PC12 cells overexpressing the insulin receptor undergo insulin-dependent neuronal differentiation. Curr. Biol., 4: 702-708, 1994.
30. Traverse, S., Seedorf, K., Paterson, H., Marshall, C. J., Cohen, P., and Ullrich, A. EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor. Curr. Biol., 4: 694-701, 1994.
31. Kono, T., and Barham, F. W. The relationship between the insulin-binding capacity of fat cells and the cellular response to insulin. Studies with intact and trypsin-treated fat cells. J. Biol. Chem., 246: 6210-6216, 1971.
32. Bergeron, J. J., Cruz, J., Khan, M. N., and Posner, B. I. Uptake of insulin and other ligands into receptor-rich endocytic components of target cells: the endosomal apparatus. Annu. Rev. Physiol., 47: 383-403, 1985.
33. Di Guglielmo, G. M., Drake, P. G., Baass, P. C., Authier, F., Posner, B. I., and Bergeron, J. J. Insulin receptor internalization and signalling. Mol. Cell. Biochem., 182: 59-63, 1998.