Characterization of the human very-long-chain acyl-CoA dehydrogenase gene promoter region: A role for activator protein 2

Molecular Genetics and Metabolism

Volumn 68, Issue 4, 1999, Pages 481-487

  Zhou, Yeqing ^a   Kelly, Daniel P ^a   Strauss, Arnold W ^a   Sims, Harold ^a   Zhang, Zhifang ^a,b  

^a ST LOUIS CHILDREN S HOSPITAL   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Fatty acids; Gene expression; Inborn errors in fatty acid oxidation; Mitochondria

Indexed keywords

ACYL COENZYME A DEHYDROGENASE; CIS ACTING ELEMENT; LUCIFERASE; OLIGONUCLEOTIDE; TRANSCRIPTION FACTOR AP 2; VERY LONG CHAIN FATTY ACID;

ANIMAL CELL; ARTICLE; BINDING COMPETITION; CELL STRAIN HEPG2; CONTROLLED STUDY; FATTY ACID OXIDATION; GENE ACTIVATION; GENE STRUCTURE; HEART MUSCLE CELL; HUMAN; HUMAN CELL; MOLECULAR CLONING; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA INTERACTION; RAT; REACTION ANALYSIS; REGULATORY MECHANISM; SEQUENCE ANALYSIS; STOICHIOMETRY; TRANSCRIPTION REGULATION;

EID: 0033402922     PISSN: 10967192     EISSN: None     Source Type: Journal    
DOI: 10.1006/mgme.1999.2933     Document Type: Article

References (22)

1. Beinert H. Acyl-coenzyme A dehydrogenases. In The Enzymes (Boyer PD, Lardy HJ, Myrbock K). New York: Academic Press, pp. 447-476, 1963.
2. Aoyama T, Ueno I, Kamijo T, Hashimoto T. Rat very-long-chain acyl-CoA dehydrogenase, a novel mitochondrial acyl-CoA dehydrogenase gene product, is a rate-limiting enzyme in long-chain fatty acid beta-oxidation system. cDNA and deduced amino acid sequence and distinct specificities of the cDNA-expressed protein. J Biol Chem 269:19088-19094, 1994.
3. Roe CR, Coates PM. Mitochondrial fatty acid oxidation disorders. In The Metabolic and Molecular Bases of Inherited Disease (Scriver CR, Beaudet AL, Sly WS, Valle D). New York: McGraw-Hill, pp. 1501-1533, 1995.
4. Kelly DP, Gordon JI, Alpers R, Strauss AW. The tissue-specific expression and developmental regulation of the two nuclear genes encoding rat mitochondrial proteins: Medium-chain acyl-CoA dehydrogenase and mitochondrial malate dehydrogenase. J Biol Chem 264:18921-18925, 1989.
5. Nagao M, Parimoo B, Tanaka K. Developmental, nutritional, and hormonal regulation of tissue-specific expression of the genes encoding various acyl-CoA dehydrogenases and α-subunit of electron transfer flavoprotein in rat. J Biol Chem 268:24114-24124, 1993.
6. Hainline BE, Kahlenbeck DJ, Grant J, Strauss AW. Tissue specific and developmental expression of rat long- and medium-chain acyl-CoA dehydrogenases. Biochim Biophys Acta 1216:460-468, 1993.
7. Disch DL, Rader TA, Cresci S, Leone TC, Barger PM, Vega R, Wood PA, Kelly DP. Transcriptional control of a nuclear gene encoding a mitochondrial fatty acid oxidation enzyme in transgenic mice: Role for nuclear receptors in cardiac and brown adipose expression. Molec Cell Biol 16:4043-4051, 1996.
8. Kelly DP, Kim JJ, Billadello JJ, Hainline BE, Chu TW, Strauss AW. Nucleotide sequence of medium-chain acyl-CoA dehydrogenase mRNA and its expression in enzyme-deficient human tissue. Proc Natl Acad Sci USA 84:4068-4072, 1987.
9. Zhang Z, Kelly DP, Kim JJ, Zhou Y, Ogden ML, Whelan AJ, Strauss AW. Structural organization and regulatory regions of the human medium-chain acyl-CoA dehydrogenase. Biochemistry 31:81-89, 1992.
10. Raisher BD, Gulick T, Zhang Z, Strauss AW, Moore DD, Kelly DP. Identification of a novel retinoid-responsive element in the promoter region of the medium chain acyl-coenzyme A dehydrogenase gene. J Biol Chem 267:20264-20269, 1992.
11. Gulick T, Cresci S, Caira T, Moore DD, Kelly DP. The peroxisome proliferator activated receptor regulates mitochondrial fatty acid oxidative enzyme gene expression. Proc Natl Acad Sci USA 91:11012-11016, 1994.
12. Wang LH, Tsai SY, Cook RG, Beattie WG, Tsai MJ, O'Malley BW. COUP transcription factor is a member of the steroid receptor superfamily. Nature 340:163-163, 1989.
13. Ladias JAA, Karathanasis SK. Regulation of the apolipoprotein AI gene by ARP-1, a novel member of the steroid receptor superfamily. Science 251:561-565, 1991.
14. Carter ME, Gulick T, Moore DD, Kelly DP. A pleiotropic element in the medium-chain acyl coenzyme A dehydrogenase gene promoter mediates transcriptional regulation by multiple nuclear receptor transcription factors and defines novel receptor-DNA binding motifs. Molec Cell Biol 14:4360-4372, 1994.
15. Zhang Z, Zhou Y, Mendelsohn NJ, Bauer GS, Strauss AW. Regulation of the human long chain acyl-CoA dehydrogenase gene by nuclear hormone receptor transcription factors. Biochim Biophys Acta 1350:53-64, 1997.
16. Sanger F, Nicklen S, Coulson AR. DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci USA 74: 5463-5467, 1977.
17. Hass RC, Strauss AW. Separate nuclear genes encode sarcomere-specific and ubiquitous human mitochondrial creatine kinase isoenzyme. J Biol Chem 265:6921-6927, 1990.
18. Brandt J, Djouadi F, Kelly DP. Fatty acids activate transcription of the muscle carnitine palmitoyltransferase I gene in cardiac myocytes via the peroxisome proliferator-activated receptor a J Biol Chem 273:23786-23793, 1998.
19. Gorman C. In DNA Cloning, A Practical Approach (Glover DM). Oxford: IRL Press, pp. 143-190, 1985.
20. Levy FH, Kelly DP. Regulation of ATP synthase subunit e gene expression by hypoxia: Cell differentiation stage-specific control. Am J Physiol 272:C457-C465, 1997.
21. Abmayr SM, Workman JL. In Current Protocolss in Molecular Biology (Ausubel FM, et al). New York: Green/Wiley-Interscience, pp. 12.1.1-12.1.9, 1990.
22. Williams T, Tjian R. Analysis of the DNA-binding and activation properties of the human transcription factor AP-2. Genes Dev 5:670-682, 1991.