Drug development, radiolabelled drugs and PET

Annals of Medicine

Volumn 31, Issue 6, 1999, Pages 432-437

  Vaalburg, Willem ^a   Hendrikse, N Harry ^a   De Vries, Erik F J ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

Drug development; Molecular biology; Pharmacodynamics; Pharmacokinetics; Positron emission tomography

Indexed keywords

COST EFFECTIVENESS ANALYSIS; DRUG DEVELOPMENT; DRUG METABOLISM; GENE EXPRESSION; GENETIC ENGINEERING; HUMAN; ISOTOPE LABELING; MOLECULAR BIOLOGY; NONHUMAN; PATHOLOGY; PHARMACODYNAMICS; PHARMACOKINETICS; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; REVIEW; TOXICOLOGY;

EID: 0033400894     PISSN: 07853890     EISSN: None     Source Type: Journal    
DOI: 10.3109/07853899908998801     Document Type: Review

References (22)

1. Fowler JS, Volkow ND, Wang GJ, Ding YS, Dewey SL. PET and drug research and development. J Nucl Med 1999; 40: 1154-63.
2. Maziere B, Delforge J. Contribution of positron emission tomography to pharmacokinetic studies. In: Welling PG, Ballant LP, eds. Handbook of Experimental Pharmacology, Vol 110. Pharmacokinetics of Drugs. Berlin: Springer-Verlag; 1994: 455-80.
3. Comar D, ed. PET for drug development and evaluation. Developments in Nuclear Medicine, Vol 26. Dordrecht, the Netherlands: Kluwer Academic Publishers; 1995.
4. Kubota R, Kubota K, Yamada S, Tada M, Takahashi T, Iwata R, et al. Methionine uptake by tumor tissue: a microautoradiographic comparison with FDG. J Nucl Med 1995; 36: 484-92.
5. van Ginkel RJ, Hoekstra HJ, Pruim J, Nieweg OE, Molenaar WM, Paans AMJ, et al. FDG-PET to evaluate response to hyperthermic isolated limb perfusion for locally advanced soft-tissue sarcoma. J Nucl Med 1996; 37: 984-90.
6. 11C]-tyrosine PET to evaluate response to hyperthermic isolated limb perfusion for locally advanced soft-tissue sarcoma and skin cancer. J Nucl Med 1999; 40: 262-7.
7. Wang GJ, Volkow ND, Fowler JS, Hitzemann RJ, Pappas NR, Netusil N. Evaluation of gender difference in regional brain metabolic responses to lorezepam. Psychiatry Res 1998; 82: 37-46.
8. Grasby PM, Frith CD, Paulesu E, Friston KJ, Frackowiak RS, Dolan RJ. The effect of the muscarinic antagonist scopolamine on regional cerebral blood flow during the performance of a memory task. Exp Brain Res 1995; 104: 337-48.
9. Farde L, Wiesel FA, Halldin C, Sedvall G. Central D2-dopamine receptor occupancy in schizophrenic patients treated with anti-psychotic drugs. Arch Gen Psychiatry 1988; 45: 71-6.
10. Regulations for in vivo radiopharmaceuticals used for diagnosis and monitoring - FDA. Proposed rule. Fed Regist 1998; 63: 28301-9.
11. Abnormal Toxicity. European Pharmacopoeia, Vol 2.1.5. Strasbourg, France: Council of Europe, European Department for the Quality of Medicines; 1987.
12. Dehdashti F, Mortimer JE, Siegel BA, Griffeth LK, Bonasera TJ, Fusselman MJ, et al. Positron tomographic assessment of estrogen receptors in breast cancer: comparison with FDG-PET and in vitro receptor assays. J Nucl Med 1995; 36: 1766-74.
13. Kubota K, Tada M, Yamada S, Hori K, Saito S, Iwata R, et al. Comparison of the distribution of fluorine-18 fluoromisonidazole, deoxyglucose and methionine in tumour tissue. Eur J Nucl Med 1999; 26: 750-7.
14. Hendrikse NH, Franssen EJF, van der Graaf WTA, Vaalburg W, de Vries EGE. Visualization of multidrug resistance in vivo. Eur J Nucl Med 1999; 26: 283-93.
15. Hendrikse NH. Dynamics of multidrug resistance; analysis with PET and single photon imaging (dissertation). Groningen, the Netherlands: University of Groningen; 1999.
16. Hendrikse NH, de Vries EGE, Eriks-Fluks E, van der Graaf WTA, Hospers GAP, Willemsen ATM, et al. A new in vivo method to study P-glycoprotein transport in tumours and the blood-brain barrier. Cancer Res 1999; 59: 2411-6.
17. Doze P, van Waarde A, Hendrikse NH, Elsinga PH, Vaalburg W. Enhanced cerebral uptake of receptor ligands by modulation of p-glycoprotein function in the blood-brain barrier. J Nucl Med 1999; 40: 72.
18. Ram Z, Culver KW, Oshiro EM, Violla JJ, De Vroom HL, Oho E, et al. Therapy of malignant brain tumors by intratumoral implantation of retroviral vector-producing cells. Nat Med 1997; 3: 1354-61.
19. Tjuvajev JG, Avril N, Oku T, Sasjima T, Miyagawa T, Joshi R, et al. Imaging of herpes virus thymidine kinase gene transfer and expression by positron emission tomography. Cancer Res 1998; 58: 4333-41.
20. Gambhir SS, Barrio JR, Phelps ME, Iyer M, Namavari M, Satyamuurthy N, et al. Imaging adenaviral-directed reporter gene expression in living animals with positron emission tomography. Proc Natl Acad Sci U S A 1999; 96: 2333-8.
21. 18F]FHPG in a two-sided tumour-bearing rat model. J Label Comp Radiopharm 1999; 42: S7-S10.
22. Tjuvajev JG, Stockhammer G, Desai R, Uehara H, Watanabe K, Gansbacher B, et al. Imaging the expression of transfected genes in vivo. Cancer Res 1995; 55: 6126-32.