Preformulation studies for the development of a parenteral liquid formulation of the immunomodulator, peldesine

PDA Journal of Pharmaceutical Science and Technology

Volumn 53, Issue 6, 1999, Pages 303-308

  Viegas, Tacey X ^a   Van Winkle, Lise L ^a  

^a BIOCRYST PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOMODULATING AGENT; PELDESINE;

ARTICLE; ASEPSIS; DRUG DOSAGE FORM; DRUG FORMULATION; DRUG MANUFACTURE; DRUG SOLUBILITY;

DRUG COMPOUNDING; DRUG STABILITY; GUANINE; IMMUNOSUPPRESSIVE AGENTS; PHARMACEUTICAL SOLUTIONS; STERILIZATION;

EID: 0033398879     PISSN: 10797440     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (8)

1. S. Bantia, J. A. Montgomery, H. G. Johnson, and G. M. Walsh, "In vivo and in vitro pharmacologic activity of the purine nucleoside phosphorylase inhibitor BCX-34: The role of GTP and dGTP," Immunopharmacology, 35, 53-63 (1996).
2. J. A. Montgomery, H. W. Snyder Jr., D. A. Walsh, and G. M. Walsh, "BCX-34: Purine nucleoside phosphorylase (PNP) inhibitor," Drugs of the Future, 18, 887-890 (1993).
3. G. M. Walsh, G. A. Omura, J. A. Montgomery, T. J. Franz, T. X. Viegas, W. J. Cook, S. Bantia, N. Reddy, W. M. Sams, Jr., A. A. Bartolucci, and H. I. Maibach, "Purine Nucleoside Phosphorylase Inhibition: A Novel Therapy for Psoriasis," In H. Roenigk and H. I. Maibach (eds.), Psoriasis, 3rd edition, Marcel Dekker, New York, pp. 781-787 (1998).
4. R. R. Goodin, R. B. Hawthorne, T. X. Viegas, and D. A. Walsh, "Quantitative determination of peldesine, a PNP inhibitor, by spectrophotmetry and high performance liquid chromatography," Pharm. Res., 12, S-70 (1995).
5. nd edition, Chapman and Hall Ltd.; London, England, 1971, p. 44.
6. A. Avdeef, J. E. Comer, and S. J. Thomson, "pH-Metric log P. 3. Glass electrode calibration in methanol-water, applied to pKa determination of water-insoluble substances," Anal. Chem., 65, 42-49 (1993).
7. G. D. Veith, N. M. Austin, and R. T. Morris, "A rapid method for estimating Log P for organic chemicals," Water Research, 13, pp. 43-47 (1979).
8. A. Avdeef and C. M. Berger, "A rapid, automated, instrument for determining solubility-pH profiles," Pharm. Sci. supplement, 1, S-24 (1998).