Sperm antibodies in rat models of male hormonal contraception and vasectomy

Reproduction, Fertility and Development

Volumn 11, Issue 1, 1999, Pages 49-57

  Veräjänkorva, Esko ^a   Martikainen, Mika ^a   Saraste, Antti ^a   Sundström, Jari ^a   Pöllänen, Pasi ^a  

^a UNIVERSITY OF TURKU   (Finland)

Author keywords

Antibody; Contraception; Epididymis; IgG; Male; Sperm; Testis

Indexed keywords

DNA; IMMUNOGLOBULIN G ANTIBODY; SPERM ANTIBODY; TESTOSTERONE;

ANDROGEN RELEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY PRODUCTION; ANTIGEN DETECTION; APOPTOSIS; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; EPIDIDYMIS; HORMONAL CONTRACEPTION; MALE; NONHUMAN; RAT; SPERM; TESTIS; VASECTOMY;

ANIMALS; ANTIBODIES; ANTIGENS; ANTIGENS, CD3; CONTRACEPTION, IMMUNOLOGIC; CONTRACEPTIVE AGENTS; IMMUNE SERA; IMMUNOGLOBULIN G; MALE; PROSTHESES AND IMPLANTS; RATS; RATS, SPRAGUE-DAWLEY; SERTOLI CELLS; SPERMATOZOA; T-LYMPHOCYTES; TESTIS; TESTOSTERONE; VASECTOMY;

ANIMALIA; MUSTELA VISON;

EID: 0033397962     PISSN: 10313613     EISSN: None     Source Type: Journal    
DOI: 10.1071/RD98082     Document Type: Article

References (25)

1. Billig, H., Furuta, I. and Hsueh, J.W. (1994). Gonadotropin-releasing hormone directly induces apoptotic cell death in the rat ovary: biochemical and in situ detection of deoxyribonucleic acid fragmentation in granulosa cells. Endocrinology 134, 245-51.
2. Flickinger, C.J., Howards, S.S., Carey, P.O., Spell, D.R., Kendrick, S.J., Caloras, D., Gallien, T.N. and Herr, J.C. (1988) Testicular alterations are linked to the presence of elevated antisperm antibodies in Sprague-Dawley rat after vasectomy and vasovasostomy. J. Urol. 140, 627-31.
3. Flickinger, C.J., Howards, S.S., Bush, L.A., Baker, L.A. and Herr, J.C. (1994). Temporal recognition of sperm autoantigens by IgM and IgG autoantibodies after vasectomy and vasovasostomy. J. Reprod. Immunol. 27, 135-50.
4. Flickinger, C.J., Howards, S.S., Bush, L.A., Baker, L.A. and Herr, J.C. (1995). Antisperm autoantibody responses to vasectomy and vasovasostomy in Fischer and Lewis rats. J. Reprod. Immunol. 28, 137-58.
5. Flickinger, C.J., Howards, S.S., Baran, M.L., Pessoa, N. and Herr, J.C. (1997). Appearance of 'natural' antisperm autoantibodies after sexual maturation of normal Lewis rats. J. Reprod. Immunol. 33, 127-45.
6. Gavrieli, Y., Sherman, Y. and Ben-Sasson, S.A. (1992). Identification of programmed cell death in situ via specific labelling of nuclear DNA fragmentation. J. Cell Biol. 119, 493-501.
7. Gunaga, K.P., Sheth, A.R. and Rao, S.S. (1970). Immunological studies with rat testis: Antigenic characterisation. J. Reprod. Fertil. 23, 263-9.
8. Handley, H.H., Flickinger, C.J. and Herr, J.C. (1988). Post-vasectomy sperm autoimmunogens in the Lewis rat. Biol. Reprod. 39, 1239-50.
9. Handley, H.H., Herr, J.C. and Flickinger, C.J. (1991). Localization of post-vasectomy sperm autoantigens in the Lewis rat. J. Reprod. Immunol. 20, 205-20.
10. Huang, H.F.S. and Nieschlag, E. (1986). Suppression of the intratesticular testosterone is associated with quantitative changes in spermatogonial populations in intact adult rats. Endocrinology 118, 619-27.
11. Johnson, M.M. (1972). The distribution of immunoglobulin and spermatozoal autoantigen in the genital tract of the male guinea pig. Fertil. Steril. 23, 383-392.
12. Johnson, M.M. and Setchell, B.P. (1968). Protein and immunoglobulin content of rete testis fluid of the rams. J. Reprod. Fertil. 17, 403-6.
13. Jones, R. and Dott, H.M. (1980). Changes in luminal plasma and disappearance of spermatozoa from the ligated cauda epididymis of the androgen-deficient rabbit. J. Reprod. Fertil. 60, 65-72.
14. Pelletier, R.M. (1994). Blood barrier of the epididymis and vas deferens act asynchronously with the blood barrier of the testis in the mink. Microsc. Res. Techn. 27, 333-49.
15. Pöllänen, P. and Cooper, T.G. (1994). Immunology of the testicular excurrent ducts. J. Reprod. Immunol. 26, 167-216.
16. Pöllänen, P., von Euler, M. and Söder, O. (1990). Testicular immunoregulatory factors. J. Reprod. Immunol. 18, 51-76.
17. Pöllänen, P., von Euler, M., Sainio-Pöllänen, S., Jahnukainen, K., Hakovirta, H., Söder, O. and Parvinen, M. (1992). Immunosuppressive activity in the seminiferous tubules. J. Reprod. Immunol. 22, 117-26.
18. Pöllänen, P., von Euler, M., Jahnukainen, K., Saari, T., Parvinen, M., Sainio-Pöllänen, S and Söder, O. (1993). Role of transforming growth factor β in testicular immunosuppression. J. Reprod. Immunol. 24, 123-37.
19. Saari, T., Jahnukainen, K. and Pöllänen, P. (1996). Autoantigenicity outside the blood-testis barrier in the rat testis. J. Reprod. Immunol. 31, 65-80.
20. Sainio-Pöllänen, S., Saari, T., Simell, O. and Pöllänen, P. (1996). CD28-CD80/CD86 interactions in testicular immunoregulation. J. Reprod. Immunol. 31, 145-63.
21. Towbin, H., Staehelin, T. and Gordon, J. (1971). Electrophoretic transfer of proteins from polyacrylamide gels to nitro-cellulose sheets: Procedure and some applications. Proc. Natl Acad. Sci. USA 76, 4350-4.
22. Tung, K.S.K., Ellis, L.E., Childs, G.V. and Dufau, M. (1984). The dark mink: a model of male infertility. Endocrinology 114, 922-9.
23. Tung, P.S. and Fritz, I.B. (1978). Specific surface antigens on rat pachytene spermatocytes and successive classes of germinal cells. Dev. Biol. 64, 297-315.
24. Vitale-Calpe, R., Fawcett, D.W and Dym, M. (1973). The normal development of the blood-testis barrier and the effects of clomiphene and estrogen treatment. Anat. Rec. 176, 333-44.
25. Yule, T.D., Montoya, G.D., Russell, L.D., Williams, T.M. and Tung, K.S.K. (1988). Autoantigenic germ cells exist outside the blood-testis barrier. J. Immunol. 141, 1161-7.