Protection against Staphylococcus aureus sepsis by vaccination with recombinant staphylococcal enterotoxin A devoid of superantigenicity

Journal of Infectious Diseases

Volumn 180, Issue 4, 1999, Pages 1370-1373

  Nilsson, Ing Marie ^a   Verdrengh, Margareta ^a   Ulrich, Robert G ^b   Bavari, Sina ^b   Tarkowski, Andrzej ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b UNITED STATES ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NEUTRALIZING ANTIBODY; STAPHYLOCOCCUS ENTEROTOXIN A;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGENICITY; ARTICLE; BACTERIAL VIRULENCE; CELL PROLIFERATION; CONTROLLED STUDY; IMMUNIZATION; MALE; MOUSE; NONHUMAN; PASSIVE IMMUNIZATION; PRIORITY JOURNAL; SEPSIS; SPLEEN CELL; STAPHYLOCOCCUS AUREUS; VACCINATION;

ANIMALS; BACTEREMIA; BACTERIAL VACCINES; ENTEROTOXINS; IMMUNIZATION, PASSIVE; MALE; MICE; MICE, INBRED STRAINS; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; VACCINES, SYNTHETIC; VIRULENCE;

EID: 0033393681     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/315023     Document Type: Article

References (14)

1. Kappler J, Kotzin B, Herron L, et al. Vβ-specific stimulation of human T cells by staphylococcal toxins. Science 1989; 244:811-3.
2. Carlsson R, Sjögren HO. Kinetics of interferon-γ production, expression of IL-2 receptors, and cell proliferation in human mononuclear cells exposed to staphylococcal enterotoxin A. Cell Immunol 1985; 96:175-83.
3. Fischer H, Dohlsten M, Andersson U, et al. Production of TNF-α and TNF-β by staphylococcal enterotoxin A activated human cells. J Immunol 1990; 144:4663-9.
4. Gjörloff A, Fischer H, Hedlund G, et al. Induction of interleukin-l in human monocytes by the superantigen staphylococcal enterotoxin A requires the participation of T-cells. Cell Immunol 1991; 137:61-71.
5. Bergdoll MS, Enterotoxins. In: Easmon CSF, Adlam C, eds. Staphylococci and staphylococcal infections. London: Academic Press, 1983:559-98.
6. Bremell T, Tarkowski A. Preferential induction of septic arthritis and mortality by superantigen-producing staphylococci. Infect Immun 1995; 63:4185-7.
7. McCollister B, Kreiswirth BN, Novick RP, Schlievert P. Production of toxic shock syndrome-like illness in rabbits by Staphylococcus aureus D4508: association with enterotoxin A. Infect Immun 1990; 58:2067-70.
8. Bavari S, Dyas B, Ulrich RG. Superantigen vaccines: a comparative study of genetically attenuated receptor-binding mutants of staphylococcal enterotoxin A. J Infect Dis 1996; 174:338-45.
9. Bremell T, Lange S, Holmdahl R, Rydén C, Hansson GK, Tarkowski A. Immunopathological features of rat Staphylococcus aurcus arthritis. Infect Immun 1994; 62:2334-44.
10. Ulrich RG, Olson MA, Bavari S. Development of engineered vaccines effective against structurally related bacterial superantigens. Vaccine 1998; 16:1857-64.
11. Abdelnour A, Tarkowski A. Polyclonal B-cell activation by an arthritogenic Staphylococcus aureus strain: contribution of T-cells and monokines. Cell Immunol 1993; 147:279-93.
12. Bone RC. Gram-positive organisms und sepsis. Arch Intern Med 1994; 154:26-34.
13. Marrack P, Blackman M, Kushnir E, Kappler J. The toxicity of staphylococcal enterotoxin B in mice is mediated by T cells. J Exp Med 1990; 171:455-64.
14. Abdelnour A, Bremell T, Holmdahl R, Tarkowski A. Clonal expansion of T lymphocytes causes arthritis and mortality in mice infected with toxic shock syndrome toxin-1 producing staphylococci. Eur J Immunol 1994; 24:1161-6.