Skin photosensitization with topical hypericin in hairless mice

Journal of Photochemistry and Photobiology B: Biology

Volumn 53, Issue 1-3, 1999, Pages 110-114

  Kamuhabwa, Appolinary R ^a   Roelandts, Rik ^b   De Witte, Peter A ^a  

^a Faculteit Farmaceutische Wetensch   (Belgium)

^b UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Hypericin; Photodynamic therapy; Photosensitization; Topical

Indexed keywords

4 HYDROXYMETHYL 2,2 DIMETHYL 1,3 DIOXOLANE; HYPERICIN; MACROGOL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; FEMALE; MALE; MOUSE; NONHUMAN; PHOTODYNAMIC THERAPY; PHOTOSENSITIZATION; PHOTOTOXICITY; PRIORITY JOURNAL; PSORIASIS;

ADMINISTRATION, TOPICAL; ANIMALS; INJECTIONS, INTRAPERITONEAL; MICE; MICE, INBRED HRS; PERYLENE; POLYETHYLENE GLYCOLS; RADIATION-SENSITIZING AGENTS; SKIN;

ANIMALIA;

EID: 0033393154     PISSN: 10111344     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1011-1344(99)00135-9     Document Type: Article

References (23)

1. Diwu Z. Novel therapeutic and diagnostic applications of hypocrellins and hypericins (review). Photochem. Photobiol. 61:1995;529-539.
2. Meruelo D., Lavie G., Lavie D. Therapeutic agents with dramatic antiretroviral activity and little toxicity at effective doses: aromatic polycyclic diones hypericin and pseudohypericin. Proc. Natl. Acad. Sci. U.S.A. 85:1988;5230-5234.
3. Lui H., Gulick R., Kollias N., Wimberly J., Crumpacker C., Anderson R. Evaluation of photosensitivity in human: hypericism (abstract). Photochem. Photobiol. (Suppl.). 55:1992;15S.
4. Koren H., Schenk G.M., Jindra R.H., Alth G., Ebermann R., Kubin A., Koderhold G., Kreitner M. Hypericin in photodynamic therapy. J. Photochem. Photobiol. B: Biol. 36:1996;113-119.
5. Agostinis P., Vandenbogaerde A., Donella-Diana A., Pinna L.A., Lee K.T., Goris J., Merlevede W., Vandenheede J.R., de Witte P. Photosensitised inhibition of growth factor-receptor protein kinases by hypericin. Biochem. Pharmacol. 49:1995;1615-1622.
6. de Witte P., Agostinis P., Van Lint J., Merlevede W., Vandenheede J.R. Inhibition of epidermal growth factor receptor tyrosine kinase activity by hypericin. Biochem. Pharmacol. 16:1993;1929-1936.
7. Agostinis P., Donella-Diana A., Cuveele J., Vandenbogaerde A., Sarno A., Merlevede W., de Witte P. A comperative analysis of the photosensitised inhibition growth factor regulated protein kinases by hypericin-derivatives. Biochem. Biophys. Res. Commun. 220:1996;613-617.
8. Mitev V.I., Miteva L., Dourmishev A. Casein kinase II activity in psoriatic epidermis. Arch. Dermatol. Res. 284:1992;111-113.
9. 125I] epidermal growth binding and receptor distribution in psoriasis. J. Invest. Dermatol. 86:1986;260-265.
10. Elder J.T., Fisher G.J., Lindquist P.B., Bennett G.L., Pittelkow M.R., Coffey R.J., Ellingsworth L., Derynck R., Voorhees J.J. Overexpression of transforming growth factor α in psoriatic epidermis. Science. 243:1986;811-814.
11. Ritcher A., Davies D.E. Effects of anthralin and hypericin on growth factor signalling and cell proliferation in vitro. Biochem. Pharmacol. 50:1995;2039-2045.
12. Ugwu F., Vandenbogaerde A.L., Merlevede W., de Witte P.A. A comparative study on phototoxicity of hypericin on A431 cells using three different assays. Anticancer Res. 18:1998;1181-1184.
13. Bissonnette R., Lui H. Current status of photodynamic therapy in dermatology. Dermatologic Clinics. 15:1997;507-519.
14. A. Kamuhabwa, K.R. Geboes, P. de Witte, Investigation on the hypericin absorption into the skin, submitted for publication.
15. Giese A.C. Hypericism. Photochem. Photobiol. Rev. 5:1980;229-255.
16. Hruza L.L., Kollias N., Lui H., Gulick R., Flotte T.J., Wimberly J., Crumpacker C., Anderson R.R. Hypericin induced cutaneous photosensitization. Clin. Res. 41:1993;502A.
17. H. Kolbabek, R.H. Jindra, A. Kubin, G. Müller, R. Ebermann, G. Alth, Photodynamic therapy by topical application of hypericin, First Internet Conf. Photochem. Photobiol., 1997, Poster P14.
18. Falk H., Meyer J., Oberreiter M. A convenient semisynthetic route to hypericin. Monatshefte für Chemie. 124:1993;339-341.
19. Falk H., Schoppel G. On the synthesis of hypericin by oxidative trimethylemodin anthrone and emodin anthrone dimerization: isohypericin. Monatshefte für Chemie. 123:1992;931-938.
20. Kubin A., Alth G., Jindra R., Jessner G., Ebermann R. Wavelength-dependent photoresponse of biological and aqueous model systems using the photodynamic plant pigment hypericin. J. Photochem. Photobiol. B: Biol. 36:1996;103-108.
21. Vandenbogaerde A.L., Geboes K.R., Cuveele J.F., Agostinis P.M., Merlevede W.J., de Witte P.A. Antitumour activity of photosensitised hypericin on A431 cell xenografts. Anticancer Res. 12:1996;1619-1626.
22. Lavie G., Mazur Y., Lavie D., Meruelo D. The chemical and biological properties of hypericin - a compound with a broad spectrum of biological activities. Med. Res. Rev. 15:1995;11-119.
23. Chung P., Saxton R., Paiva M., Rhee C., Soudant J., Mathey A., Foote C., Castrol D. Hypericin uptake in rabbits and nude mice transplanted with human squamous cell carcinoma: study of a new sensitizer for laser phototherapy. Laryngoscope. 104:1994;1471-1475.