In vitro apoptosis of lymphocytes after exposure to levels of corticosterone observed following submaximal exercise

Journal of Sports Medicine and Physical Fitness

Volumn 39, Issue 4, 1999, Pages 269-274

  Hoffman Goetz, L ^a   Zajchowski, S ^a  

^a UNIVERSITY OF WATERLOO   (Canada)

Author keywords

Apoptosis; Corticosterone; Exercise physiology; Spleen; T Lymphocytes; Thymus gland

Indexed keywords

CORTICOSTERONE; LIPOCORTIN 5;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONCENTRATION RESPONSE; CORTICOSTERONE BLOOD LEVEL; EXERCISE; FEMALE; IMMUNE RESPONSE; LYMPHOCYTE DEPLETION; MOUSE; NONHUMAN; PERIPHERAL LYMPHOCYTE; STEROID THERAPY; TREADMILL EXERCISE;

ANIMALS; ANTI-INFLAMMATORY AGENTS; APOPTOSIS; CORTICOSTERONE; FEMALE; LYMPHOCYTES; MICE; MICE, INBRED C57BL; PHYSICAL CONDITIONING, ANIMAL;

EID: 0033392203     PISSN: 00224707     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Zhou J, Olsen S, Moldovan J, Fu X, Sarkar FH, Moudgil VK et al. Glucocorticoid regulation of natural cytotoxicity: effects of cortisol on the phenotype and function of a cloned human natural killer cell line. Cell Immunol 1997;178:108-16.
2. Buckingham JC, Loxley HD, Taylor AD, Flower RJ. Cytokines, glucocorticoids and neuroendocrine function. Pharmacol Res 1994;30:35-42.
3. Wyllie AH. Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature 1980;284:555-6.
4. Cashmore GC, Davies CTM, Few JD. Relationship between increases in plasma cortisol concentration and rates of cortisol secretion during exercise in man. J Endocrinol 1977;72:109-10.
5. Jain S, Bruot BC, Stevenson JR. Cold swim stress leads to enhanced splenocyte responsiveness to concanavalin A, decreased serum testosterone, and increased serum corticosterone, glucose, and protein. Life Sci 1996;56:209-18.
6. Concordet JP, Ferry A. Physiological programmed cell death in thymocytes is induced by physical stress (exercise). Am J Physiol 1993;265:C626-9.
7. Niess AM, Baumann M, Roecker K, Horstmann T, Mayer F, Dickhuth H-H. Effects of intensive endurance exercise on DNA damage in leucocytes. J Sports Med Phys Fitness 1998;38:111-5.
8. Ferry AP, Rieu F, Laziri C, Guezennec Y, El Habazi A, LePage C et al. Immunomodulation of thymocytes and splenocytes in trained rats. J Appl Physiol 1991;71:815-20.
9. Lin Y-S, Kuo H-L, Kuo C-F, Wang S-T, Yang B-C, Chen H-I. Antioxidant administration inhibits exercise-induced thymocyte apoptosis in rats. Med Sci Sports Exerc (in press).
10. Hoffman-Goetz L, Zajchowski S, Aldred A. Impact of treadmill exercise on early apoptotic cells in mouse thymus and spleen. Life Sci 1999;64:191-200.
11. MacNeil B, Hoffman-Goetz L, Kendall A. Houston ME, Arumugam Y. Lymphocyte proliferative responses in men: fitness, intensity and duration effects. J Appl Physiol 1991;70:179-85.
12. Vermes I, Haanen C, Teutelingsperger CPM. A novel assay for apoptosis: flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled annexin V. J Immunol Meth 1995;180:39-52.
13. Luger A, Deuster PA, Kyle SB, Gallucchi WT, Montgomery C, Gold PW et al. Acute hypothalamic-pituitary-adrenal responses to the stress of treadmill exercise. N Engl J Med 1987;316:1309-15.
14. Field CJ, Gougeon R, Marliss EB. Circulating mononuclear cell numbers and function during intense exercise and recovery. J Appl Physiol 1991;71:1089-97.
15. Nieman DC, Simandle S, Henson DA, Warren BJ, Suttles J, Davis JM et al. Lymphocyte proliferative responses to 2.5 hours of running. Int J Sports Med 1995;16:404-9.
16. Bodey B, Bodey B Jr, Siegel SE, Kaiser HE. Involution of mammalian thymus, one of the leading regulators of aging. In Vivo 1997;11:421-40.
17. Collier SD, Wu WJ, Pruett SB. Endogenous glucocorticoids induced by a chemical stress (ethanol) cause apoptosis in the spleen in B6C3F1 female mice. Toxicol Appl Pharmacol 1998;148:176-82.
18. Weil MM, Amos CI, Mason KA, Stephens LC. Genetic basis of strain variation in levels of radiation-induced apoptosis of thymocytes. Radiat Res 1996;6:646-51.
19. Nakanishi T, Nishi Y, Sato EF, Ishii M, Hamada T, Inoue M. Thermal injury induced thymocyte apoptosis in the rat. J Trauma Infect Crit Care 1998;44:143-8.
20. Teodorczyk-Ineyan JA, Cembrzynska-Nowak M, Lalani S, Peters WJ, Mills GB. Immune deficiency following thermal trauma is associated with apoptotic cell death. J Clin Immunol 1995;15: 318-28.