Immunosuppressive activity of cepacidine A, a novel antifungal antibiotic produced by Pseudomonas cepacia

Journal of Microbiology and Biotechnology

Volumn 9, Issue 5, 1999, Pages 672-674

  Lee, Chul Hoon ^a   Suh, Jung Woo ^b   Cho, Youl Hee ^a  

^a Hanyang University   (South Korea)

^b CJ Corporation   (South Korea)

Author keywords

Antifungal antibiotic; Cepacidine A; Immunosuppressive activity

Indexed keywords

ANTIFUNGAL AGENT; CEPACIDINE A; MITOGENIC AGENT; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; ARTICLE; BIOTECHNOLOGY; BURKHOLDERIA CEPACIA; CONCENTRATION RESPONSE; DELAYED HYPERSENSITIVITY; DRUG ACTIVITY; DRUG ISOLATION; DRUG STRUCTURE; HEMAGGLUTINATION; IMMUNOMODULATION; LYMPHOCYTE; NONHUMAN; SHEEP ERYTHROCYTE;

BURKHOLDERIA; BURKHOLDERIA CEPACIA; FUNGI; MURINAE; OVIS ARIES; PSEUDOMONAS;

EID: 0033390997     PISSN: 10177825     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Dayton, J. S., L. A. Turka, C. B. Thompson, and B. S. Mitchell. 1992. Comparison of the effects of mizoribine with those of azathioprine, 6-mercaptopurine, and mycophenolic acid on T lymphocyte proliferation. Mol. Pharmacol. 41: 671-676.
2. Goto, T., T. Kino, H. Hatanaka, M. Nishiyama, M. Okuhara, M. Kohsaka, H. Aoki, and H. Imanaka. 1987. Discovery of FK-506, a novel immunosuppressant isolated from Streptomyces tsukubaensis. Transplant Proc. 19(suppl. 6): 4-8.
3. Grieswold, D. E., J. A. DiLorenzo, and P Calabresi. 1974. Quantification and pharmacological dissection of oxazolone-induced contact sensitivity in the mouse. Cell Immunol. 11: 198-204.
4. Lee, C.-H., S. Kim, B. Hyun, J. Suh, C. Yon, C. Kim, Y. Lim, and C. Kim. 1994. Cepacidine A, a novel antifungal antibiotic produced by Pseudomonas cepacia. I. Taxonomy, isolation and biological activity. J. Antibiot. 47: 1402-1405.
5. Lee, S.-Y., S. B. Han, H. S. Kim, Y. H. Kim, H. M. Kim, C. J. Kim, S. D. Hong, and J.-J. Lee. 1997. Immunosuppressive characteristics of oligomycin derivatives produced by Streptomyces lydicus MCY-524. J. Microbiol. Biotechnol. 7: 56-61.
6. Lim, Y., J. Suh, S. Kim, B. Hyun, C. Kim, and C.-H. Lee. 1994. Cepacidine A, a novel antifungal antibiotic produced by Pseudomonas cepacia. II. Physico-chemical properties and structure elucidation. J. Antibiot. 47: 1406-1416.
7. Martel, R. R., J. Klicius, and S. Galet. 1977. Inhibition of the immune response by rapamycin, a new antifungal antibiotic. Can. J. Physiol. Pharmacol. 55: 48-51.
8. Mishell, B. B. and S. M. Shiigi. 1980. Cell proliferation, pp. 153-160. In B. B. Mishell and S. M. Shiigi (eds.), Selected Methods in Cellular Immunology, vol. 5. W.H. Freeman Co., San Francisco, U.S.A.
9. Nakamura, A., K. Nagai, S. Suzuki, K. Ando, and G. Tamura. 1986. A novel method of screening for immunomodulating substances, establishment of an assay and its application to culture broths of microorganisms. J. Antibiot. 39: 1148-1154.
10. White, D. J. G. and R. Y. Calne. 1982. The use of cyclosporin A immunosuppression in organ grafting. Immun. Rev. 65: 115-131.