Stimulated nitric oxide release and nitric oxide sensitivity in forearm arterial vasculature during normotensive and preeclamptic pregnancy

American Journal of Obstetrics and Gynecology

Volumn 181, Issue 6, 1999, Pages 1479-1485

  Anumba, Dilly O C ^b   Ford, Gary A ^b   Boys, Richard J ^b   Robson, Stephen C ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b NONE

Author keywords

Nitric oxide; Preeclampsia; Pregnancy; Serotonin; Vascular resistance

Indexed keywords

GLYCERYL TRINITRATE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; RITODRINE; SEROTONIN; SEROTONIN RECEPTOR;

ADULT; ARTICLE; CONTROLLED STUDY; ENZYME SUBSTRATE; FEMALE; FOREARM BLOOD FLOW; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN TISSUE; NORMAL HUMAN; PLETHYSMOGRAPHY; PREECLAMPSIA; PRIORITY JOURNAL; SEROTONIN RELEASE; VASCULAR SMOOTH MUSCLE; VASODILATATION;

EID: 0033390934     PISSN: 00029378     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9378(99)70394-7     Document Type: Article

References (27)

1. 1. Robson SC, Hunter S, Boys RJ, Dunlop W. Serial study of factors influencing changes in cardiac output during human pregnancy. Am J Physiol 1989;256:111060-5.
2. 2. Vallance P, Collier J, Moncada S. Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man. Lancet 1989;2:997-1000.
3. G-monomethyl-L-arginine in postpartum and nonpregnant women. Clin Sci (Colch) 1996;90:493-7.
4. 4. Anumba DOC, Ford GA, Boys RJ, Robson SC. Nitric oxide activity in the forearm vasculature of pregnant and preeclamptic women. Am J Physiol 1999;277:H848-54.
5. 5. Williams DJ, Vallance PJT, Neild GH, Spencer JAD, Imms FJ. Nitric oxide mediated vasodilatation in human pregnancy. Am J Physiol 1997;272:11748-52.
6. 7. Boccardo P, Soregaroli M, Aiello S, Noris M, Donadelli R, Lojacono A, et al. Systemic and fetal-maternal nitric-oxide synthesis in normal pregnancy and preeclampsia. Br J Obstet Gynaecol 1996;103:879-86.
7. 6. Weiner CP, Lizasoain I, Baylis SA, Knowles RG, Charles IG, Moncada S. Induction of calcium-dependent nitric-oxide synthases by sex hormones. Proc Natl Acad Sci U S A 1994;91: 5212-6.
8. 8. McCarthy AL, Taylor P, Graves J, Raju SK, Poston L. Endothelium-dependent relaxation of human resistance arteries in pregnancy. Am J Obstet Gynecol 1994;171:1309-15.
9. 9. McCarthy AL, Woolfson RG, Raju SK, Poston L. Abnormal endothelial-cell function of resistance arteries from women with preeclampsia. Am J Obstet Gynecol 1993;168:1323-30.
10. 10. Silver RK, Kupfermine MJ, Russell TL, Adler L, Mullen TA, Caplan MS. Evaluation of nitric oxide as a mediator of severe preeclampsia. Am J Obstet Gynecol 1996;175:1013-7.
11. 3 receptor. J Cardiovasc Pharmacol 1993;22: 44-51.
12. 12. Bruning TA, van Zwieten PA, Blauw GJ, Chang PC. No functional involvement of 5-hydroxytryptamine1A receptors in nitric oxide-dependent dilatation caused by serotonin in the human forearm vascular bed. J Cardiovasc Pharmacol 1994; 24:454-61.
13. 13. Whitney RJ. The measurement of volume changes in human limbs. J Physiol 1953;121:1-27.
14. 14. Mathews JNS, Altman DG, Campbell MJ, Royston P. Analysis of serial measurements in medical research. BMJ 1990;300:230-5.
15. 15. Knock GA, Poston L. Bradykinin-mediated relaxation of isolated maternal resistance arteries in normal pregnancy and preeclampsia. Am J Obstet Gynecol 1996;175:1668-74.
16. 16. Moncada S, Palmer RMJ, Higgs EA. Nitric oxide: physiology, pathophysiology, and pharmacology. Pharmacol Rev 1991;43: 109-42.
17. 17. Ranjan V, Xiao Z, Diamond SL. Constitutive NOS expression in cultured endothelial cells is elevated by fluid shear stress. Am J Physiol 1995;269:H550-5.
18. 18. Kukovetz WR, Poch G, Holzmann S. Cyclic nucleotides and relaxation of vascular smooth muscle. In: Vanhoutte PM, Leuzen I, editors. Vasodilatation. New York: Raven Press; 1981. p. 339-53.
19. 19. Liao JK, Homcy CJ. The G proteins of the G alpha i and G alpha q family couple the bradykinin receptor to the release of endothelium-derived relaxing factor. J Clin Invest 1993;92: 2168-72.
20. 20. Panza JA, Casino PR, Badar DM, Quyyumi AA. Effect of increased availability of endothelium-derived nitric oxide precursor on endothelium-dependent vascular relaxation in normal subjects and in patients with essential hypertension. Circulation 1993;87:1475-81.
21. 21. Pascoal IF, Lindheimer MD, Nalbantian-Brandt C, Umans JG. Preeclampsia selectively impairs endothelium-dependent relaxation and leads to oscillatory activity in small omental arteries. J Clin Invest 1998;101:464-70.
22. 22. O'Kane KP, Webb DJ, Collier JG, Vallance PJ. Local L-NG-monomethyl-arginine attenuates the vasodilator action of bradykinin in the human forearm. Br J Clin Pharmacol 1994;38:311-5.
23. 23. Newby DE, Boon NA, Webb DJ. Comparison of forearm vasodilatation to substance P and acetylcholine: contribution of nitric oxide. Clin Sci (Colch) 1997;92:133-8.
24. 24. Pascoal IF, Umans JG. Effect of pregnancy on mechanisms of relaxation in human omental microvessels. Hypertension 1996;28:183-7.
25. 25. Anumba DOC, Robson SC, Ford GA. Flow mediated nitric oxide activity in the forearm vasculature of pregnant and nonpregnant women [abstract]. Br J Clin Pharmacol 1998;45: 190P-1P.
26. 20. Hurwitz R, Campbell RW, Gordon P, Haddy FJ. Interaction of serotonin with vasoconstrictor agents in the vascular bed of the denervated dog forelimb. J Pharmacol Exp Ther 1961;133: 57-62.
27. 27. Bruning TA, Chang PC, Blauw GJ, Vermeij P, van Zwieten PA. Interactions between serotonin and endogenous and exogenous noradrenaline in the human forearm. Blood Press 1994;3:309-18.