Postoperative borderline elevated CEA predicts for earlier relapse in patients with rectal cancer receiving adjuvant postoperative therapy

Cancer Journal from Scientific American

Volumn 5, Issue 6, 1999, Pages 374-379

  Dawson, Laura A ^a   Franssen, Edmee ^b,c   Davey, Phillip ^b,c,d  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d DEPARTMENT OF RADIATION ONCOLOGY   (Canada)

Author keywords

Adjuvant therapy; Carcinoembryonic antigen; CEA; Prognostic factors; Rectal cancer

Indexed keywords

CARCINOEMBRYONIC ANTIGEN;

ADULT; AGED; ARTICLE; CANCER STAGING; CANCER SURVIVAL; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; POSTOPERATIVE PERIOD; PREDICTION; PRIORITY JOURNAL; RECTUM CANCER; RELAPSE;

AGED; CARCINOEMBRYONIC ANTIGEN; CHEMOTHERAPY, ADJUVANT; FEMALE; HUMANS; MALE; MIDDLE AGED; POSTOPERATIVE PERIOD; RADIOTHERAPY, ADJUVANT; RECTAL NEOPLASMS; RETROSPECTIVE STUDIES; SURVIVAL RATE;

EID: 0033388937     PISSN: 10814442     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (40)

1. Cohen AM, Minsky BD, Schilsky RL. Cancer of the rectum. In: DeVita V, Hellman S, Rosenberg S, eds. Caputo's Cancer: Principles and Practice of Oncology (5th ed). Philadelphia: Lippincott-Raven, 1997:1205.
2. Krook JE, Moertel CG, Gunderson LL et al. Effective surgical adjuvant therapy for high-risk rectal carcinoma. N Engl J Med 1991;324:709-715.
3. Thomas PR, Lindblad AS. Adjuvant postoperative radiotherapy and chemotherapy in rectal carcinoma: a review of the Gastrointestinal Tumor Study Group experience. Radiother Oncol 1988; 13:245-252.
4. Fisher B, Wolmark N, Rockette H et al. Postoperative adjuvant chemotherapy or radiation therapy for rectal cancer: results from NSABP protocol R-01. J Natl Cancer Inst 1988;80:21-29.
5. Minsky BD, Mies C, Rich TA et al. Potentially curative surgery of colon cancer: the influence of blood vessel invasion. J Clin Oncol 1988;6:119-127.
6. Cohen AM, Minsky BD, Schilsky RL. Cancer of the Colon. In: DeVita V, Hellman S, Rosenberg S, eds. Caputo's Cancer: Principles and Practice of Oncology (5th ed). Philadelphia: Lippincott-Raven, 1997:1177.
7. Lindmark G, Gerdin B, Pahlman L et al. Prognostic predictors in colorectal cancer. Dis Colon Rectum 1994;37:1219-1227
8. Minsky BD, Mies C, Rich TA et al. Lymphatic vessel invasion is an independent prognostic factor for survival in colorectal cancer. Int J Radiat Oncol Biol Phys 1989;17:311-318.
9. Bognel C, Rekacewicz C, Mankarios H et al. Prognostic value of neural invasion in rectal carcinoma: a multivariate analysis on 339 patients with curative resection. Eur J Cancer 1995;31A:894-898.
10. Symonds DA, Vickery AL. Mucinous carcinoma of the colon and rectum. Cancer 1976;37:1891-1900.
11. Steinberg SM, Barwick KW, Stablein DM. Importance of tumor pathology and morphology in patients with surgically resected colon cancer: findings from the Gastrointestinal Tumor Study Group. Cancer 1986;58:1340-1345.
12. Gold P, Freedman SO. Specific carcinoembryonic antigens of the human digestive system. J Exp Med 1965;122:467-481.
13. Donaldson E, Van Nagell JR Jr, Wood EG et al. Carcinoembryonic antigen in patients treated with radiation therapy for invasive squamous cell carcinoma of the uterine cervix. AJR Am J Roentgenol 1976;127:829-831.
14. Wanebo HJ, Rao B, Pinsky CM et al. Preoperative carcinoembryonic antigen level as a prognostic indicator in colorectal cancer. N Engl J Med 1978;299:448-451.
15. Wolmark N, Fisher B, Wieand HS et al. The prognostic significance of preoperative carcinoembryonic antigen levels in colorectal cancer: results from NSABP (National Surgical Adjuvant Breast and Bowel Project) clinical trials. Ann Surg 1984;199:375-382.
16. Aabo K, Pedersen H, Kjaer M. Carcinoembryonic antigen (CEA) and alkaline phosphatase in progressive colorectal cancer with special reference to patient survival. Eur J Cancer Clin Oncol 1986; 22:211-217.
17. Kohler JP, Simonowitz D, Paloyan D. Preoperative CEA level: a prognostic test in patients with colorectal carcinoma. Am Surgeon 1980;46:449-452.
18. Staab HJ, Anderer FA, Brummendorf T et al. Prognostic value of preoperative serum CEA level compared to clinical staging: I. colorectal carcinoma. Br J Cancer 1981;44:652-662.
19. Onetto M, Paganuzzi M, Secco GB et al. Preoperative carcinoembryonic antigen and prognosis in patients with colorectal cancer. Biomed Pharmacother 1985;39:392-395.
20. Szymendera JJ, Nowacki MP, Szawlowski AW et al. Predictive value of plasma CEA levels: preoperative prognosis and postoperative monitoring of patients with colorectal carcinoma. Dis Colon Rectum 1982;25:46-52.
21. Goslin R, Steele G Jr, Macintyre J et al. The use of preoperative plasma CEA levels for the stratification of patients after curative resection of colorectal cancers. Ann Surg 1980;192:747-751.
22. Blake KE, Dalbow MH, Concannon JP et al. Clinical significance of the preoperative plasma carcinoembryonic antigen (CEA) level in patients with carcinoma of the large bowel. Dis Colon Rectum 1982;25:24-32.
23. Lewi H, Blumgart LH, Carter DC et al. Pre-operative carcinoembryonic antigen and survival in patients with colorectal cancer. Br J Surg 1984;71:206-208.
24. Chapuis PH, Newland RC, Payne JE et al. Preoperative carcinoembryonic antigen level and prognosis in colorectal cancer. Med J Austr 1980;2:140-143.
25. Evans JT, Mittelman A, Chu M et al. Pre- and postoperative uses of CEA. Cancer 1978;42:1419-1421.
26. Moertel CG, O'Fallon JR, Go VL et al. The preoperative carcinoembryonic antigen test in the diagnosis, staging, and prognosis of colorectal cancer. Cancer 1986;58:603-610.
27. Rognum TO, Thorud E, Brandtzaeg P et al. Plasma CEA in large bowel carcinoma: which patients should be followed by regular postoperative measurements? Preliminary follow-up results in 100 patients with different tumor DNA-ploidy patterns. Cancer Detect Prev 1987;10:347-352.
28. Herrera MA, Chu TM, Holyoke ED. Carcinoembryonic antigen (CEA) as a prognostic and monitoring test in clinically complete resection of colorectal carcinoma. Ann Surgery 1976;183:5-9.
29. Bentzen SM, Balslev I, Pedersen M et al. Time to loco-regional recurrence after resection of Dukes' B and C colorectal cancer with or without adjuvant postoperative radiotherapy. A multivariate regression analysis. Br J Cancer 1992;65:102-107.
30. Sener SF, Imperato JP, Chmiel J et al. The use of cancer registry data to study preoperative carcinoembryonic antigen level as an indicator of survival in colorectal cancer [review]. CA Cancer J Clin 1989;39:50-57.
31. Steele G Jr, Ellenberg S, Ramming K et al. CEA monitoring among patients in multi-institutional adjuvant G.I. therapy protocols. Ann Surg 1982;196:162-169.
32. Staab HJ, Anderer FA, Brummendorf T et al. Prognostic significance of preoperative carcinoembryonic antigen in stomach and colorectal cancer. Cancer Detect Prev 1983;6:149-153.
33. Lavin PT, Day J, Holyoke ED et al. A statistical evaluation of baseline and follow-up carcinoembryonic antigen in patients with resectable colorectal carcinoma. Cancer 1981;47:823-826.
34. Midiri G, Amanti C, Consorti F et al. Usefulness of preoperative CEA levels in the assessment of colorectal cancer patient stage. J Surg Oncol 1983;22:257-260.
35. Molnar L, Rahoty P, Bauer E et al. Correlation between the results of carcinoembryonal antigen (CEA) test and the clinical stage of colorectal carcinoma. Acta Chir Hung 1986;27:27-34.
36. Minton JP, Hoehn JL, Gerber DM et al. Results of a 400-patient carcinoembryonic antigen second-look colorectal cancer study. Cancer 1985;55:1284-1290.
37. Tate H. Plasma CEA in the post-surgical monitoring of colorectal carcinoma. Br J Cancer 1982;46:323-330.
38. Persijn JP, Hart AA. Prognostic significance of CEA in colorectal cancer: a statistical study. J Clin Chem Clin Biochem 1981;19: 1117-1123.
39. Davey P, Arnott SJ, Sturgeon CM. Carcinoembryonic antigen as a prognostic indicator in the radiotherapeutic management of rectal cancer. Eur J Surg Oncol 1987;13:17-20.
40. Arnott SJ. Plasma carcinoembryonic antigen (CEA) as an indicator for radical or palliative radiotherapy in patients with rectal cancer. Cancer Detect Prevent 1983;6:155-159.