Visualizing a new binding site of ncd-motor domain on tubulin

Journal of Structural Biology

Volumn 128, Issue 1, 1999, Pages 26-33

  Han, Y ^a   Sablin, E P ^b   Nogales, E ^a,c   Fletterick, R J ^b   Downing, K H ^a  

^a LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

KINESIN; TUBULIN;

ALPHA CHAIN; ARTICLE; BETA CHAIN; BINDING SITE; MICROTUBULE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN PROTEIN INTERACTION;

EID: 0033386726     PISSN: 10478477     EISSN: None     Source Type: Journal    
DOI: 10.1006/jsbi.1999.4162     Document Type: Article

References (31)

1. Amos L., Hirose K. The structure of microtubule-motor complexes. Curr. Biol. 9:1997;4-11.
2. Case R. B., Pierce D. W., Hom-Booher N., Hart C. L., Vale R. D. The directional preference of kinesin motors is specified by an element outside of the motor catalytic domain. Cell. 90:1997;959-966.
3. Crevel I. M.-T., Lockhart A., Cross R. A. Weak and strong states of kinesin and ncd. J. Mol. Biol. 257:1996;66-76.
4. Crowther R. A., Henderson R., Smith J. M. MRC image processing programs. J. Struct. Biol. 116:1996;9-16.
5. deCastro M. J., Ho C. H., Stewart R. J. Motility of dimeric ncd on a metal-chelating surfactant: Evidence that ncd is not processive. Biochemistry. 38:1999;5076-5081.
6. Downing K. H. Spot-scan imaging in transmission electron microscopy. Science. 251:1991;53-59.
7. Downing K. H. Automatic focus correction for spot-scan imaging of tilted specimens. Ultramicroscopy. 46:1992;199-206.
8. Endow S. A., Waligora K. W. Determinants of kinesin motor polarity. Science. 281:1998;1200-1202.
9. Gulick A. M., Song H., Endow S. A., Rayment I. X-ray crystal structure of the yeast Kar3 motor domain complexed with Mg · ADP to 2.3 Å resolution. Biochemistry. 37:1998;1769-1776.
10. Hirose K., Cross R. A., Amos L. A. Nucleotide-dependent structural changes in dimeric NCD molecules complexed to microtubules. J. Mol. Biol. 278:1998;389-400.
11. Hoenger A., Milligan R. A. Motor domains of kinesin and ncd interact with microtubule protofilaments with the same binding geometry. J. Mol. Biol. 265:1997;553-564.
12. Hoenger A., Sack S., Thormahlen M., Marx A., Muller J., Gross H., Mandelkow E. Image reconstructions of microtubules decorated with monomeric and dimeric kinesins: Comparison with X-ray structure and implications for motility. J. Cell Biol. 4:1998;419-430.
13. Kozielski F., Arnal I., Wade R. H. A model for the microtubule-kinesin complex based on electron cryomicroscopy and x-ray crystallography. Curr. Biol. 8:1998;191-198.
14. Kozielski F., Sack S., Marx A., Thormahlen M., Schonbrunn E., Biou V., Thompson A., Mandelkow E.-M., Mandelkow E. The crystal structure of dimeric kinesin and implications for microtubule-dependent motility. Cell. 91:1997;985-994.
15. Kull F. J., Sablin E. P., Lau R., Fletterick R. J., Vale R. D. Crystal structure of the kinesin motor domain reveals a structural similarity to myosin. Nature. 380:1996;550-554.
16. Mandelkow E., Hoenger A. Structures of kinesin and kinesin-microtubule interactions. Curr. Opin. Cell Biol. 11:1999;34-44.
17. Mandelkow E., Johnson K. A. The structural and mechanochemical cycle of kinesin. Trends Biochem. Sci. 23:1998;429-433.
18. McDonald H. B., Stewart R. J., Goldstein L. S. The kinesin-like ncd protein of Drosophila is a minus end-directed microtubule motor. Cell. 63:1990;1159-1165.
19. Nogales E., Whittaker M., Milligan R. A., Downing K. H. High resolution model of the microtubule. Cell. 96:1999;79-88.
20. Nogales E., Wolf S. G., Downing K. H. Structure of the αβ tubulin dimer by electron crystallography. Nature. 391:1998;199-203.
21. Nogales E., Wolf S. G., Khan I. A., Ludueña R. F., Downing K. H. Structure of tubulin at 6.5 Å and location of the taxol-binding site. Nature. 375:1995a;424-427.
22. Nogales E., Wolf S. G., Zhang S. X., Downing K. H. Preservation of 2-D crystals of tubulin for electron crystallography. J. Struct. Biol. 115:1995b;199-208.
23. Ray S., Wolf S. G., Howard J., Downing K. H. Kinesin does not support the motility of zinc-macrotubes. Cell Motil. Cytoskel. 30:1995;146-152.
24. Sablin E. P., Case R. B., Dai S. C., Hart C. L., Ruby A., Vale R. D., Fletterick R. J. Direction determination in the minus-end directed kinesin motor ncd. Nature. 395:1998;813-816.
25. Sablin E. P., Kull F. J., Cooke R., Vale R. D., Fletterick R. J. Crystal structure of the motor domain of the kinesin-related motor ncd. Nature. 380:1996;555-559.
26. Sack S., Muller J., Marx A., Thormahlen M., Mandelkow E. M., Brady S. T., Mandelkow E. X-ray structure of motor and neck domains from rat brain kinesin. Biochemistry. 36:1997;16155-16165.
27. Schmid M. F., Dargahi R., Tam M. W. SPECTRA: A system for processing electron images of crystals. Ultramicroscopy. 48:1993;251-264.
28. Sosa H., Dias D. P., Hoenger A., Whittaker M., Wilson-Kubalek E., Sablin E., Fletterick R. J., Vale R. D., Milligan R. A. A model for the microtubule-Ncd motor protein complex obtained by cryo-electron microscopy and image analysis. Cell. 90:1997;217-224.
29. Stewart R. J., Semerjian J., Schmidt C. F. Highly processive motility is not a general feature of the kinesins. Eur. Biophys. J. 27:1998;353-360.
30. Vale R. D., Fletterick R. J. The design plan of kinesin motors. Annu. Rev. Cell Dev. Biol. 13:1997;745-777.
31. Walker R. A., Salmon E. D., Endow S. A. The Drosophila claret segregations protein is a minus-end directed motor molecule. Nature. 347:1990;780-782.