Histone acetyltransferase complexes and their link to transcription

Critical Reviews in Eukaryotic Gene Expression

Volumn 9, Issue 3-4, 1999, Pages 231-243

  Howe, LeAnn ^a   Brown, Christine E ^a   Lechner, Thomas ^a   Workman, Jerry L ^a  

^a PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

Acetyltransferase complexes; Histone; Transcription

Indexed keywords

HISTONE ACETYLTRANSFERASE;

ACETYLATION; CHROMATIN; DNA HISTONE INTERACTION; ENZYME LOCALIZATION; ENZYME SPECIFICITY; GENETIC TRANSCRIPTION; PRIORITY JOURNAL; PROTEIN QUATERNARY STRUCTURE; REVIEW;

EID: 0033385496     PISSN: 10454403     EISSN: None     Source Type: Journal    
DOI: 10.1615/CritRevEukarGeneExpr.v9.i3-4.80     Document Type: Review

References (119)

1. Abraham SE, Lobo S, Yaciuk P, Wang HG, Moran E (1993): p300, and p300-associated proteins, are components of TATA-binding protein (TBP) complexes. Oncogene 8:1639-1647.
2. Adams CR, Kamakaka RT (1999): Chromatin assembly: biochemical identities and genetic redundancy. Curr Opin Genet Dev 9:185-190.
3. Allard S, Utley R, Savard J, Clark A, Grant P, Brandi C, Pillus L, Workman J, Cote J (1999): NuA4, an essential transcription adaptor/histone H4 acetyltransferase complex containing Esa1p and the ATM-related cofactor Tra1p. EMBO J 18 (in press).
4. Allegra P, Sterner R, Clayton DF, Allfrey VG (1987): Affinity chromatographic purification of nucleosomes containing transcriptionally active DNA sequences. J Mol Biol 196:379-388.
5. Ausió J, van Holde KE (1986): Histone hyperacetylation: its effects on nucleosome conformation and stability. Biochemistry 25:1421-1428.
6. Bannister AJ, Kouzarides T (1996): The CBP coactivator is a histone acetyltransferase. Nature 384:641-643.
7. Barlev NA, Candau R, Wang L, Darpino P, Silverman N, Berger SL (1995): Characterization of physical interactions of the putative transcriptional adaptor, ADA2, with acidic activation domains and TATA-binding protein. J Biol Chem 270:19337-19344.
8. Belyaev N, Keohane AM, Turner BM (1996): Differential underacetylation of histones H2A, H3 and H4 on the inactive X chromosome in human female cells. Hum Genet 97:573-578.
9. Belyaev ND, Houben A, Baranczewski P, Schubert I (1998): The acetylation patterns of histones H3 and H4 along Vicia faba chromosomes are different. Chromosome Res 6:59-63.
10. Boggs BA, Connors B, Sobel RE, Chinault AC, Allis CD (1996): Reduced levels of histone H3 acetylation on the inactive X chromosome in human females. Chromosoma 105:303-309.
11. Borrow J, Stanton VPJ, Andresen JM, Becher RB, Chaganti RS, Civin CI, Disteche C, Dube I, Frischauf AM, Horsman D, Mitelman F, Volinia S, Watmore AE, Housman DE (1996): The translocation t(8;16) (p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein. Nat Genet 14:33-41.
12. Boyes J, Byfield P, Nakatani Y, Ogryzko V (1998): Regulation of activity of the transcription factor GATA-1 by acetylation. Nature 396:594-598.
13. Brady ME, Ozanne DM, Gaughan L, Waite I, Cook S, Neal DE, Robson CN (1999): Tip60 is a nuclear hormone receptor coactivator. J Biol Chem 274:17599-17604.
14. Brand M, Yamamoto K, Staub A, Tora L (1999): Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction. J Biol Chem 274:18285-18289.
15. Braunstein M, Rose AB, Holmes SG, Allis CD, Broach JR (1993): Transcriptional silencing in yeast is associated with reduced nucleosome acetylation. Genes Dev 7: 592-604.
16. Braunstein M, Sobel RE, Allis CD, Turner BM, Broach JR (1996): Efficient transcriptional silencing in Saccharomyces cerevisiae requires a heterochromatin histone acetylation pattern. Mol Cell Biol 16:4349-4356.
17. Brownell JE, Zhou J, Ranalli T, Kobayashi R, Edmondson DG, Roth SY, Allis CD (1996): Tetrahymena histone acetyltransferase A: a homolog to yeast GcnSp linking histone acetylation to gene activation. Cell 84:843-851.
18. Buzek J, Riha K, Siroky J, Ebert I, Greilhuber J, Vyskot B (1998): Histone H4 underacetylation in plant facultative heterochromatin. Biol Chem 379:1235-1241.
19. Candau R, Moore PA, Wang L, Barlev N, Ying CY, Rosen CA, Berger SL (1996): Identification of human proteins functionally conserved with the yeast putative adaptors ADA2 and GCN5. Mol Cell Biol 16:593-602.
20. Chen H, Lin RJ, Schiltz RL, Chakravarti D, Nash A, Nagy L, Privalsky ML, Nakatani Y, Evans RM (1997): Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300. Cell 90:569-580.
21. Clarke AS, Lowell JE, Jacobson SJ, Pillus L (1999): Esa1p is an essential histone acetyltransferase required for cell cycle progression. Mol Cell Biol 19:2515-2526.
22. Cosma MP, Tanaka T, Nasmyth K (1999): Ordered recruitment of transcription and chromatin remodeling factors to cell cycle and developmentally regulated promoters. Cell 97:299-311.
23. Creaven M, Hans F, Mutskov V, Col E, Caron C, Dimitrov S, Khochbin S (1999): Control of the histone-acetyltransferase activity of Tip60 by the HIV-1 transactivator protein, Tat. Biochemistry 38:8826-8830.
24. Dallas PB, Yaciuk P, Moran E (1997): Characterization of monoclonal antibodies raised against p300: both p300 and CBP are present in intracellular TBP complexes. J Virol 71:1726-1731.
25. Dechend R, Hirano F, Lehmann K, Heissmeyer V, Ansieau S, Wulczyn FG, Scheidereit C, Leutz A (1999): The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/ Rel and nuclear co-regulators. Oncogene 18:3316-3323.
26. Eberharter A, Sterner D, Schieltz D, Hassan A, Yates J III, Berger S, Workman J (1999): The ADA complex is a distinct histone acetyltransferase complex in Saccharomyces cerevisiae. Mol Cell Biol 19 (in press).
27. Ehrenhofer-Murray AE, Rivier DH, Rine J (1997): The role of Sas2, an acetyltransferase homologue of Saccharomyces cerevisiae, in silencing and ORC function. Genetics 145:923-934.
28. Eisenmann DM, Arnt KM, Ricupero SL, Rooney JW, Winston F (1992): SPT3 interacts with TFIID to allow normal transcription in Saccharomyces cerevisiae. Genes Dev 6:1319-1331.
29. Felzien LK, Farrell S, Betts JC, Mosavin R, Nabel GJ (1999): Specificity of cyclin E-Cdk2, TFIIB, and E1A interactions with a common domain of the p300 coactivator. Mol Cell Biol 19:4241-4246.
30. Garcia-Ramirez M, Rocchini C, Ausio J (1995): Modulation of chromatin folding by histone acetylation. J Biol Chem 270:17923-17928.
31. Georgakopoulos T, Thireos G (1992): Two distinct yeast transcriptional activators require the function of the GCN5 protein to promote normal levels of transcription. EMBO J 11:4145-4152.
32. Grant P, Schieltz D, Pray-Grant M, Steger D, Reese J, Yates J III, Workman J (1998a): A subset of TAFIIs are integral components of the SAGA complex required for nucleosome acetylation and transcription stimulation. Cell 94:45-53.
33. Grant P, Sterner D, Duggan L, Workman J, Berger S (1998b): The SAGA unfolds: convergence of transcription regulators in chromatin-modifying complexes. Trends Cell Biol 8:193-197.
34. Grant PA, Schieltz D, Pray-Grant MG, Yates JRR, Workman JL (1998c): The ATM-related cofactor Tra1 is a component of the purified SAGA complex. Mol Cell 2:863-867.
35. Grant PA, Duggan L, Côté J, Roberts SM, Brownell JE, Candau R, Ohba R, Owen-Hughes T, Allis CD, Winston F, Berger SL, Workman JL (1997): Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complex. Genes Dev 11:1640-1650.
36. Grant PA, Eberharter A, John S, Cook RG, Turner BM, Workman JL (1999): Expanded lysine acetylation specificity of Gcn5 in native complexes. J Biol Chem 274: 5895-5900.
37. Grunstein M (1997): Histone acetylation in chromatin structure and transcription. Nature 389:349-352.
38. Gu W, Roeder RG (1997): Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain. Cell 90:595-606.
39. Gu W, Szauter P, Lucchesi JC (1998): Targeting of MOF, a putative histone acetyltransferase, to the X chromosome of Drosophila melanogaster. Dev Genet 22:56-64.
40. Hahn S (1998): The role of TAFs in RNA polymerase II transcription. Cell 95:579-582.
41. Hebbes TR, Clayton AL, Thorne AW, Crane-Robinson C (1994): Core histone hyperacetylation co-maps with generalized DNase I sensitivity in the chicken ß-globin chromosomal domain. EMBO J 13:1823-1830.
42. Hebbes TR, Thorne AW, Clayton AL, Crane-Robinson C (1992): Histone acetylation and globin gene switching. Nucleic Acids Res 20:1017-1022.
43. Hebbes TR, Thorne AW, Crane-Robinson C (1988): A direct link between core histone acetylation and transcriptionally active chromatin. EMBO J 7:1395-1402.
44. Herrera JE, Sakaguchi K, Bergel M, Trieschmann L, Nakatani Y, Bustin M (1999): Specific acetylation of chromosomal protein HMG-17 by PCAF alters its interaction with nucleosomes. Mol Cell Biol 19:3466-3473.
45. Hilfiker A, Hilfiker-Kleiner D, Pannuti A, Lucchesi JC (1997): mof, a putative acetyl transferase gene related to the Tip60 and MOZ human genes and to the SAS genes of yeast, is required for dosage compensation in Drosophila. EMBO J 16:2054-2060.
46. Hong L, Schroth GP, Matthews HR, Yau P, Bradbury EM (1993): Studies of the DNA binding properties of histone H4 amino terminus: thermal denaturation studies reveal that acetylation markedly reduces the binding constant of the H4 "tail" to DNA. J Biol Chem 268:305-314.
47. Iizuka M, Stillman B (1999): Histone acetyltransferase HBO1 interacts with the ORC1 subunit of the human initiator protein [in process citation]. J Biol Chem 274: 23027-23034.
48. Ikeda K, Steger DJ, Eberharter A, Workman JL (1999): Activation domain-specific and general transcription stimulation by native histone acetyltransferase complexes. Mol Cell Biol 19:855-863.
49. Imhof A, Yang X-J, Ogryzko VV, Nakatani Y, Wolffe AP, Ge H (1997): Acetylation of general transcription factors by histone acetyltransferases. Curr Biol 7:689-692.
50. Janknecht R, Hunter T (1996): Transcription. A growing coactivator network [news; comment]. Nature 383:22-23.
51. Jayaraman G, Srinivas R, Duggan C, Ferreira E, Swaminathan S, Somasundaram K, Williams J, Hauser C, Kurkinen M, Dhar R, Weitzman S, Buttice G, Thimmapaya B (1999): p300/cAMP-responsive element-binding protein interactions with ets-1 and ets-2 in the transcriptional activation of the human stromelysin promoter. J Biol Chem 274:17342-17352.
52. Jeppesen P, Mitchell A, Turner B, Perry P (1992): Antibodies to defined histone epitopes reveal variations in chromatin conformation and underacetylation of centric heterochromatin in human metaphase chromosomes. Chromosoma 101:322-332.
53. Jeppesen P, Turner BM (1993): The inactive X chromosome in female mammals is distinguished by a lack of histone H4 acetylation, a cytogenic marker for gene expression. Cell 74:281-289.
54. Johnson CA, O'Neill LP, Mitchell A, Turner BM (1998): Distinctive patterns of histone H4 acetylation are associated with defined sequence elements within both heterochromatic and euchromatic regions of the human genome. Nucleic Acids Res 26:994-1001.
55. Johnson EM, Sterner R, Allfrey VG (1987): Altered nucleosomes of active nucleolar chromatin contain accessigle histone H3 in its hyperacetylated form. J Biol Chem 262:6943-6946.
56. Kamine J, Elangovan B, Subramanian T, Coleman D, Chinnadurai G (1996): Identification of a cellular protein that specifically interacts with the essential cysteine region of the HIV-1 Tat transactivator. Virology 216:356-366.
57. Kimura A, Horikoshi M (1998): Tip60 acetylates six lysines of a specific class in core histones in vitro. Genes Cells 3:789-800.
58. Kleff S, Andrulis ED, Anderson CW, Sternglanz R (1995): Identification of a gene encoding a yeast histone H4 acetyltransferase. J Biol Chem 270:24674-24677.
59. Korzus E, Torchia J, Rose DW, Xu L, Kurokawa R, McInerney EM, Mullen TM, Glass CK, Rosenfeld MG (1998): Transcription factor-specific requirements for coactivators and their acetyltransferase functions. Science 279:703-707.
60. Krebs JE, Kuo M-H, Allis CD, Peterson CL (1999): Cell cycle-regulated histone acetylation required for expression of the yeast HO gene. Genes Dev 13:1412-1421.
61. Kundu TK, Wang Z, Roeder RG (1999): Human TFIIIC relieves chromatin-mediated repression of RNA polymerase III transcription and contains an intrinsic histone acetyltransferase activity. Mol Cell Biol 19: 1605-1615.
62. Kuo M-H, Zhou J, Jambeck P, Churchill MEA, Allis CD (1998): Histone acetyltransferase activity of yeast Gcn5p is required for the activation of target genes in vivo. Genes Dev 12:627-639.
63. Kuo MH, Brownell JE, Sobel RE, Ranalli TA, Cook RG, Edmondson DG, Roth SY, Allis CD (1996): Transcription-linked acetylation by Gcn5p of histones H3 and H4 at specific lysines. Nature 383:269-272.
64. Kwok RP, Lundblad JR, Chrivia JC, Richards JP, Bachinger HP, Brennan RG, Roberts SG, Green MR, Goodman RH (1994): Nuclear protein CBP is a coactivator for the transcription factor CREB [see comments]. Nature 370:223-226.
65. Libertini LJ, Ausio J, van Holde KE, Small EW (1988): Histone hyperacetylation. Its effects on nucleosome core particle transitions. Biophys J 53:477-487.
66. Lin R, Leone JW, Cook RG, Allis CD (1989): Antibodies specific to acetylated histones document the existence of deposition- and transcription-related histone acetylation in Tetrahymena. J Cell Biol 108:1577-1588.
67. Liu L, Scolnick DM, Trievel RC, Zhang HB, Marmorstein R, Halazonetis TD, Berger SL (1999): p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage. Mol Cell Biol 19:1202-1209.
68. Luger K, Mäder AW, Richmond RK, Sargent DF, Richmond TJ (1997): Crystal structure of the nucleosome core particle at 2.8 Å resolution. Nature 389:251-260.
69. Ma XJ, Wu J, Altheim BA, Schultz MC, Grunstein M (1998): Deposition-related sites K5/K12 in histone H4 are not required for nucleosome deposition in yeast. Proc Natl Acad Sci USA 95:6693-6698.
70. Marcus GA, Silverman N, Berger SL, Horiuchi J, Guarente L (1994): Functional similarity and physical association between GCN5 and ADA2: putative transcriptional adaptors. EMBO J 13:4807-4815.
71. Martinez E, Kundu TK, Fu J, Roeder RG (1998): A human SPT3-TAFII31-GCN5-L acetylase complex distinct from transcription factor IID [published erratum appears in J Biol Chem 1998 Oct 16: 273(42):27755]. J Biol Chem 273:23781-23785.
72. Martinez-Balbas MA, Bannister AJ, Martin K, Haus-Seuffert P, Meisterernst M, Kouzarides T (1998a): The acetyltransferase activity of CBP stimulates transcription. EMBO J 17:2886-2893.
73. Martinez-Balbas MA, Tsukiyama T, Gdula D, Wu C (1998b): Drosophila NURF-55, a WD repeat protein involved in histone metabolism. Proc Natl Acad Sci USA 95:132-137.
74. McMahon SB, Van Buskirk HA, Dugan KA, Copeland TD, Cole MD (1998): The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins. Cell 94:363-374.
75. Mizzen CA, Yang X-J, Kokubo T, Brownell JE, Bannister AJ, Owen-Hughes T, Workman JL, Wang L, Berger SL, Kouzarides T, Nakatani Y, Allis CD (1996): The TAFII250 subunit of TFIID has histone acetyltransferase activity. Cell 87:1261-1270.
76. Munshi N, Merika M, Yie J, Senger K, Chen G, Thanos D (1998): Acetylation of HMG I(Y) by CBP turns off IFN beta expression by disrupting the enhanceosome. Mol Cell 2:457-467.
77. Mutskov V, Gerber D, Angelov D, Ausio J, Workman J, Dimitrov S (1998): Persistent interactions of core histone tails with nucleosomal DNA following acetylation and transcription factor binding. Mol Cell Biol 18:6293-6304.
78. Natarajan K, Jackson BM, Zhou H, Winston F, Hinnebusch A (1999): Transcriptional activation by Gcn4p involves independent interactions with SWI/SNF complex and SB/mediator (submitted).
79. Nightingale KP, Wellinger RE, Sogo JM, Becker PB (1998): Histone acetylation facilitates RNA polymerase II transcription of the Drosophila hsp26 gene in chromatin. EMBO J 17:2865-2876.
80. Norton VG, Marvin KW, Yau P, Bradbury EM (1990): Nucleosome linking number change controlled by acetylation of histones H3 and H4. J Biol Chem 265: 19848-19852.
81. Ogryzko VV, Kotani T, Zhang X, Schlitz RL, Howard T, Yang XJ, Howard BH, Qin J, Nakatani Y (1998): Histone-like TAFs within the PCAF histone acetylase complex. Cell 94:35-44.
82. Ogryzko VV, Schiltz RL, Russanova V, Howard BH, Nakatani Y (1996): The transcriptional coactivalors p300 and CBP are histone acetyltransferases. Cell 87:953-959.
83. Ohba R, Steger DJ, Brownell JE, Mizzen CA, Cook RG, Cote J, Workman JL, Allis CD (1999): A novel H2A/ H4 nucleosomal histone acetyltransferase in Tetrahymena thermophila. Mol Cell Biol 19:2061-2068.
84. Parekh BS, Maniatis T (1999): Virus infection leads to localized hyperacetylation of histones H3 and H4 at the IFN-beta promoter. Mol Cell 3:125-129.
85. Parthun MR, Jaehning JA (1990): Purification and characterization of the yeast transcriptional activator GAL4. J Biol Chem 265:209-213.
86. Parthun MR, Widom J, Gottschling DE (1996): The major cytoplasmic histone acetyltransferase in yeast: links to chromatin replication and histone metabolism. Cell 87:85-94.
87. Perez-Martin J, Johnson AD (1998): Mutations in chromatin components suppress a defect of Gcn5 protein in Saccharomyces cerevisiae. Mol Cell Biol 18:1049-1054.
88. Pollard KJ, Peterson CL (1997): Role of ADA/GCN5 products in antagonizing chromatin-mediated transcriptional repression. Mol Cell Biol 17:6212-6222.
89. Puri PL, Sartorelli V, Yang X-J, Hamamori Y, Ogryzko VV, Howard BH, Kedes L, Wang JYJ, Graessmann A, Nakatani Y, Levrero M (1997): Differential role of p300 and PCAF acetyltransferases in muscle differentiation. Mol Cell 1:35-45.
90. Reifsnyder C, Lowell J, Clarke A, Pillus L (1996): Yeast SAS silencing genes and human genes associated with AML and HIV-1 Tat interactions are homologous with acetyltransferases. Nat Genet 14:42-49.
91. Ridsdale JA, Davie JR (1987): Chicken erythrocyte polynucleosomes which are soluble at physiological ionic strength and contain linker histones are highly enriched in β-globin gene sequences. Nucleic Acids Res 15:1081-1097.
92. Rundlett SE, Carmen AA, Suka N, Turner BM, Grunstein M (1998): Transcriptional repression by UME6 involves deacetylation of lysine 5 of histone H4 by RPD3. Nature 392:831-835.
93. Sakaguchi K, Herrera JE, Saito S, Miki T, Bustin M, Vassilev A, Anderson CW, Appella E (1998): DNA damage activates p53 through a phosphorylation-acetylation cascade. Genes Dev 12:2831-2841.
94. Schiltz RL, Mizzen CA, Vassilev A, Cook RG, Allis CD, Nakatani Y (1999): Overlapping but distinct patterns of histone acetylation by the human coactivators p300 and PCAF within nucleosomal substrates. J Biol Chem 274:1189-1192.
95. Smith ER, Belote JM, Schiltz RL, Yang XJ, Moore PA, Berger SL, Nakatani Y, Allis CD (1998a): Cloning of Drosophila GCN5: conserved features among metazoan GCN5 family members. Nucleic Acids Res 26: 2948-2954.
96. Smith ER, Eisen A, Gu W, Sattah M, Pannuti A, Zhou J, Cook RG, Lucchesi JC, Allis CD (1998b): ESA1 is a histone acetyltransferase that is essential for growth in yeast. Proc Natl Acad Sci USA 95:3561-3565.
97. Sobel RE, Cook RG, Perry CA, Annunziato AT, Allis CD (1995): Conservation of deposition-related acetylation sites in newly synthesized histones H3 and H4. Proc Natl Acad Sci USA 92:1237-1241.
98. Spencer TE, Jenster G, Burcin MM, Allis CD, Zhou J, Mizzen CA, McKenna NJ, Onate SA, Tsai SY, Tsai M-J, O'Malley BW (1997): Steroid receptor coactivator-1 is a histone acetyltransferase. Nature 389:194-198.
99. Steger DJ, Eberharter A, John S, Grant PA, Workman JL (1998): Purified histone acetyltransferase complexes stimulate HIV-1 transcription from preassembled nucleosomal arrays. Proc Natl Acad Sci USA 95: 12924-12929.
100. Steger DJ, Utley RT, Grant PA, John S, Eberharter A, Côté J, Owen-Hughes T, Ikeda K, Workman JL (1998): Regulation of transcription by multisubunit complexes that alter nucleosome structure. Cold Spring Harbor Symp Quant Biol LXIII:483-491.
101. Sterner DE, Grant PA, Roberts SM, Duggan L, Belotserkovskaya R, Pacella LA, Winston F, Workman JL, Berger SL (1999): Functional organization of the yeast SAGA complex: distinct components involved in structural integrity, nucleosome acetylation, and TATA-binding protein interaction. Mol Cell Biol 19:86-98.
102. Taunton J, Hassig CA, Schreiber SL (1996): A mammalian histone deacetylase related to the yeast transcriptional regulator Rpd3p. Science 272:408-411.
103. Tazi J, Bird A (1990): Alternative chromatin structure at CpG islands. Cell 60:909-920.
104. Tse C, Georgieva EI, Ruiz-García AB, Sendra R, Hansen JC (1998a): Gcn5p, a transcription-related histone acetyltransferase, acetylates nucleosomes and folded nucleosomal arrays in the absence of other protein subunits. J Biol Chem 273:32388-32392.
105. Tse C, Sera T, Wolffe AP, Hansen JC (1998b): Disruption of higher-order folding by core histone acetylation dramatically enhances transcription of nucleosomal arrays by RNA polymerase III. Mol Cell Biol 18:4629-4638.
106. Turner BM, Birley AJ, Lavender J (1992): Histone H4 isoforms acetylated at specific lysine residues define individual chromosomes and chromatin domains in Drosophila polytene nuclei. Cell 69:375-384.
107. Utley RT, Ikeda K, Grant PA, Côté J, Steger DJ, Eberharter A, John S, Workman JL (1998): Transcriptional activators direct histone acetyltransferase complexes to nucleosomes. Nature 394:498-502.
108. Vassilev A, Yamauchi J, Kotani T, Prives C, Avantaggiati ML, Qin J, Nakatani Y (1998): The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily. Mol Cell 2:869-875.
109. Vavra KJ, Allis CD, Gorovsky MA (1982): Regulation of histone acetylation in Tetrahymena macro- and micro-nuclei. J Biol Chem 257:2591-2598.
110. Verreault A, Kaufman PD, Kobayashi R, Stillman B (1998): Nucleosomal DNA regulates the core-histone-binding subunit of the human Hat1 acetyltransferase. Curr Biol 8:96-108.
111. Wade P, Jones PL, Vermaakr D, Wolffe AP (1998): A multiple subunit Mi-2 histone deacetylase from Xenopus laevis cofractionates with an associated Snf2 superfamily ATPase. Curr Biol 8:843-846.
112. Wang L, Liu L, Berger SL (1998): Critical residues for histone acetylation by Gcn5, functioning in Ada and SAGA complexes, are also required for transcriptional function in vivo. Genes Dev 12:640-653.
113. Wittschieben BO, Otero G, de Bizemont T, Fellows J, Erdjument-Bromage H, Ohba R, Li Y, Allis CD, Tempst P, Svejstrup JQ (1999): A novel histone acetyltransferase is an integral subunit of elongating RNA polymerase II holoenzyme [in process citation]. Mol Cell 4:123-128.
114. Xu L, Glass CK, Rosenfeld MG (1999): Coactivator and corepressor complexes in nuclear receptor function. Curr Opin Genet Dev 9:140-147.
115. Xu L, Lavinsky RM, Dasen JS, Flynn SE, McInerney EM, Mullen TM, Heinzel T, Szeto D, Korzus E, Kurokawa R, Aggarwal AK, Rose DW, Glass CK, Rosenfeld MG (1998a): Signal-specific co-activator domain requirements for Pit-1 activation. Nature 395:301-306.
116. Xu W, Edmondson DG, Roth SY (1998b): Mammalian GCN5 and P/CAF acetyltransferases have homologous amino-terminal domains important for recognition of nucleosomal substrates. Mol Cell Biol 18:5659-5669.
117. Yang X-J, Ogryzko VV, Nishikawa J-I, Howard BH, Nakatani Y (1996): A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A. Nature 382:319-324.
118. Zhang W, Bieker JJ (1998): Acetylation and modulation of erythroid Kruppel-like factor (EKLF) activity by interaction with histone acetyltransferases. Proc Natl Acad Sci USA 95:9855-9860.
119. Zhang Y, Iratni R, Erdjument-Bromage H, Tempst P, Reinberg D (1997): Histone deacetylase and SAP18, a novel polypeptide, are components of a human Sin3 complex. Cell 89:357-364.