DNA-damaging effects of genotoxins in mixture: Nonadditive effects of aflatoxin B1 and N-acetylaminofluorene on their mutagenicity in Salmonella typhimurium

Toxicological Sciences

Volumn 52, Issue 2, 1999, Pages 226-231

  Said, Boctor ^a   Ross, Matthew K ^a   Hamade, Ali K ^a   Matsumoto, Diane C ^a   Shank, Ronald C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Aflatoxin B1; Aflatoxin B1 8,9 epoxide (AFB1 8,9 epoxide); Genotoxins; Mixtures; Mutagenicity; N acetoxy acetylaminofluorene (N AcO AAF); N acetylaminofluorene; Salmonella assay

Indexed keywords

AFLATOXIN B1; N (2 FLUORENYL)ACETAMIDE;

ARTICLE; CARCINOGEN DNA INTERACTION; CONCENTRATION RESPONSE; DNA DAMAGE; ENVIRONMENTAL EXPOSURE; FRAMESHIFT MUTATION; GENOTOXICITY; MUTAGENICITY; NONHUMAN; SALMONELLA TYPHIMURIUM;

EID: 0033384964     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/52.2.226     Document Type: Article

References (32)

1. Crebelli, R., Conti, L., Fuselli, S., Leopardi, P., Zijno, A., and Carere, A. (1991). Further studies on the comutagenic activity of cigarette smoke condensate. Mutat. Res, 259, 29-36.
2. Feron, V. J., Groten, J. P., van Zorge, J. A., Cassee, F. R., Jonker, D., and van Bladeren, P. J. (1995). Toxicity studies in rats of simple mixtures of chemicals with the same or different target organs. Toxicol. Lett. 82/83, 505-512.
3. 1 is MucAB dependent in Escherichia coli. J. Bacteriol. 170, 3415-3420.
4. 1 8,9-epoxide using m-chloroperbenzoic acid. Chem. Res. Toxicol. 6, 313-316.
5. Janel-Bintz, R., Maenhaut-Michel, G., and Fuchs, R. P. P. (1994). MucAB but not UmuDC proteins enhance -2 frameshift mutagenesis induced by N-2-acetylaminofluorene at alternating GC sequences. Mol. Gen. Genet. 245, 279-285.
6. Johnson, W. W., and Guengerich, F. P. (1997). Reaction of aflatoxin Bl-epoxide with DNA: kinetic analysis of covalent binding and DNA induced hydrolysis. Proc. Natl. Acad. Sci. U S A 94, 6121-6125.
7. Josephy, P. D., Lord, H. L., and Snieckus, V. A. (1990). Inhibition of benzo(a)pyrene dihydrodiol epoxide mutagenicity by synthetic analogues of ellagic acid. Mutat. Res. 242, 143-149.
8. Kawalek, J. C., and Andrews, A. W. (1981). Effect of aromatic hydrocarbons on the metabolism of 2-aminoanthracene to mutagenic products in the Ames assay. Carcinogenesis 2, 1367-1369.
9. Little, J. W. (1983). The SOS regulatory system: Control of its state by the level of recA protease. J. Mol. Biol. 167, 791-808.
10. 1, in the Salmonella microsuspension assay. Mutat. Res. 398, 183-187.
11. Maenhaut-Michel, G., Janel-Bintz, R., and Fuchs, R. P. P. (1992). A umuDC-independent SOS pathway for frameshift mutagenesis. Mol. Gen. Genet. 235, 373-380.
12. Mandel, R., and Ryser, H. J. -P. (1984). Mutagenicity of cadmium in Salmonella typhimurium and its synergism with two nitrosamines. Mutat. Res. 138, 9-16.
13. Maron, D. M., and Ames, B. N. (1983). Revised methods for the Salmonella mutagenicity test. Mutat. Res. 113, 173-215.
14. McCann, J., Springarn, N. E., Kobori, J., and Ames, B. N. (1975). Detection of carcinogens as mutagens: bacterial tester strains with R factor plasmids. Proc. Natl. Acad. Sci. U S A 72, 979-983.
15. Miller, E. C., Juhl, U., and Miller, J. A. (1966). Nucleic acid guanine: Reaction with the carcinogen N-acetoxy-2-acetylaminofluorene. Science 153, 1125-1127.
16. Ogawa, S., Hirayama, J., Nohara, M., Tokuda, M., Hirai, K., and Fukui, S. (1985). The effect of quercetin on the mutagenicity of 2-acetylaminofluorene and benzo(a)pyrene in Salmonella typhimurium strain. Mutat. Res. 142, 103-107.
17. Ogawa, S., Hirayma, T., Tokuda, M., Hirai, K., and Fukui, S. (1987). Mutagenicity-enhancing effect of quercetin on the active metabolites of 2-acetylaminofluorene with mammalian metabolic activation systems. Mutat. Res. 190, 241-246.
18. Pan, Y.-H., and Reed, G. A. (1997). Metabolic and genotoxic interactions of 2-aminofluorene and 2,4-diaminotoluene. Toxicol. Lett. 91, 73-82.
19. Ross, M. K., Said, B., and Shank, R. C. (1999). DNA-damaging effects of genotoxins in mixture: modulation of covalent binding to DNA. Toxicol. Sci. (in press).
20. Said, B., Ross, M. K., Salib, T., and Shank, R. C. (1995). Modulation of DNA adduct formation by successive exposures of DNA to small and bulky chemical carcinogens. Carcinogenesis 16, 3057-3062.
21. Said, B., and Shank, R. C. (1991). Nearest-neighbor effects on carcinogen binding to guanine runs in DNA. Nucleic Acids Res. 19, 1311-1316.
22. Sexton, K., Beck, B. D., Bingham, E., Brain, J. D., DeMarini, D. M., Hertzberg, R. C., O'Flaherty, E. J., and Pounds, J. G. (1995). Chemical mixtures from a public health perspective: The importance of research for informed decision making. Toxicology 105, 429-441.
23. + -dependent mutagenesis. Mol. Gen. Genet. 179, 289-297.
24. Smythe, H. F., Weil, C. S., West, J. S., and Carpenter, C. P. (1969). An exploration of joint toxic action: Twenty-seven industrial chemicals intubated in rats in all possible pairs. Toxicol. Appl. Pharmacol. 14, 340-347.
25. Surh, Y.-J., Shlyankevich, M., Lee, J. W., and Yoo, J.-K. (1996). Inhibition of covalent DNA binding and mutagenicity of benzo[a]pyrene by isopropyl-2-(1,3-dithietane-2-ylidene)-2[N-(4-methylthiazol-2-yl)carbomyl] acetate (YH439), a novel hepatoprotective agent. Mutat. Res. 367, 219-224.
26. Urios, A., Herrera, G., Aleixandre, V., and Blanco, M. (1994). Influence of the processing of MucA protein on the reversion of the frameshift hisD3052 and the base-substitution hisG46 mutations by chemical mutagens in Salmonella typhimurium. Mutat. Res. 323, 63-67.
27. Walker, G. C. and Dobson, P. P. (1997). Mutagenesis and repair deficiencies of Escherichia coli umuC mutants are suppressed by the plasmid pKM101. Mol. Gen. Genet. 172, 17-24.
28. Wang, C. Y., Lee, M.-S., and Zukowski, K. (1991). Inhibition by diacylmethane derivatives of mutagenicity in Salmonella typhimurium and tRNA-binding of chemical carcinogens. Mutat. Res. 262, 189-193.
29. Weng, C. Y., Martinez, A. J., and Park, D. L. (1997). Anti-aflatoxin mutagenic factors in corn. Food Addit. Contam. 14, 269-279.
30. Whong, W. Z., Lu, C. H., Stewart, J. D., Jiang, H. X., and Ong, T. (1989). Genotoxicity and genotoxic enhancing effects of tetrandrine in Salmonella typhimurium. Mutat. Res. 222, 237-244.
31. Woodgate, R., and Sefwick, S. G. (1992). Mutagenesis induced by bacterial UmuDC proteins and their plasmid homologues. Mol. Microbiol. 6, 2213-2218.
32. Yoshida, D., Matsumoto, T., and Okamoto, H. (1979). Interaction between amino-α-carboline and amino-γ-carboline on mutagenicity in Salmonella typhimurium, Mutat. Res. 68, 175-178.