Increased forearm blood flow during glucose clamp is related neither to insulin sensitivity nor to hyperinsulinemia in borderline hypertensive young men

Blood Pressure

Volumn 8, Issue 4, 1999, Pages 227-232

  Høieggen, Aud ^a,b   Fossum, Eigil ^a   Moan, Andreas ^a   Rostrup, Morten ^a   Eide, Ivar K ^a   Kjeldsen, Sverre E ^a  

^a UNIVERSITY OF OSLO   (Norway)

^b ULLEVÅL UNIVERSITY HOSPITAL   (Norway)

Author keywords

Forearm blood flow; Insulin; Insulin resistance; Vasodilation

Indexed keywords

GLUCOSE; INSULIN;

ADULT; ARTICLE; BLOOD FLOW VELOCITY; BLOOD FLOWMETRY; BORDERLINE HYPERTENSION; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; FOREARM BLOOD FLOW; GLUCOSE CLAMP TECHNIQUE; HUMAN; HYPERINSULINEMIA; INSULIN BLOOD LEVEL; INSULIN SENSITIVITY; MALE; PRIORITY JOURNAL;

EID: 0033383944     PISSN: 08037051     EISSN: None     Source Type: Journal    
DOI: 10.1080/080370599439616     Document Type: Article

References (28)

1. Laakso M, Edelman V, Brechtel G, Baron AD. Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man: a novel mechanism for insulin resistance. J Clin Invest 1990; 85: 1844-52.
2. Laakso M, Edelman V, Brechtel G, Baron AD. Impaired insulin-mediated skeletal muscle blood flow in patients with NIDDM. Diabetes 1992; 41: 1076-83.
3. Bonadonna RC, Saccomani MP, Del Prato S, Bonora E, DeFronzo R, Cobelli C. Role of tissue-specific blood flow and tissue recruitment in insulin-mediated glucose uptake of human skeletal muscle. Circulation 1998; 98: 234-41.
4. Utriainen T, Malmström R, Mäkimattila S, Yki-Järvinen H. Methodological aspects, dose-response characteristics and causes of interindividual variation in insulin stimulation of limb blood flow in normal subjects. Diabetologia 1995; 38: 555-64.
5. Laine H, Knuuti MJ, Ruotsalainen U, et al. Insulin resistance in essential hypertension is characterized by impaired insulin stimulation of blood flow in skeletal muscle. J Hypertens 1998; 16: 211-9.
6. Laine H, Knuuti MJ, Ruotsalainen U, et al. Preserved relative dispersion but blunted stimulation of mean flow, absolute dispersion, and blood volume by insulin in skeletal muscle of patients with essential hypertension. Circulation 1998; 97: 2146-53.
7. Anderson EA, Hoffman RP, Balon TW, Sinkey CA, Mark AL. Hyperinsulinemia produces both sympathetic neural activation and vasodilatation in normal humans. J Clin Invest 1991; 87: 2246-52.
8. Natali A, Taddei S, Galvan AQ, et al. Insulin sensitivity, vascular reactivity, and clamp-induced vasodilatation in essential hypertension. Circulation 1997; 96: 849-55.
9. Anderson EA, Balon TW, Hoffman RP, Sinkey CA, Mark AL. Insulin increases sympathetic activity but not blood pressure in borderline hypertensive humans. Hypertension 1992; 19: 621-7.
10. DeFronzo RA, Jacot E, Jequier E, Maeder E, Wahren J, Felber JP. The effect of insulin on the disposal of intravenous glucose. Diabetes 1981; 30: 1000-7.
11. DeFronzo RA, Ferrannini E, Hendler R, Felig P, Wahren J, Felber JP. Regulation of splanchnic and peripheral glucose uptake by insulin and hyperglycemia in man. Diabetes 1983; 32: 35-45.
12. Hausberg M, Mark AL, Hoffman RP, Sinkey CA, Anderson EA. Dissociation of sympathoexitatory and vasodilator actions of modestly elevated plasma insulin levels. J Hypertens 1995; 13: 1015-21.
13. Cleland SJ, Petrie JR, Ueda S, Elliot HL, Connell JMC. Insulin as a vascular hormone: implications for the pathophysiology of cardiovascular disease. Clin Exp Pharm Phys 1998; 25: 175-84.
14. Yki-Järvinen , Utriainen T. Insulin-induced vasodilation: physiology or pharmacology? Diabetologia 1998; 41: 369-79.
15. Baron AD, Brechtel G. Insulin differentially regulates systemic and skeletal muscle vascular resistance. Am J Physiol 1993; 265: E61-7.
16. Moan A, Nordby G, Os I, Birkeland KI, Kjeldsen SE. Relationship between hemorrheological factors and insulin resistance in healthy young men. Metabolism 1994; 43: 423-7.
17. Fossum E, Høieggen A, Moan A, Nordby G, Kjeldsen SE. Insulin sensitivity relates to other cardiovascular risk factors in young men: validation of some modifications of the hyperinsulinemic, isoglycemic glucose clamp technique. Blood Pressure 1997; 6: 113-9.
18. Høieggen A, Fossum E, Moan A, Enger E, Kjeldsen SE. Whole blood viscosity and the insulin resistance syndrome. J Hypertens 1998; 16: 203-10.
19. Rostrup M, Westheim A, Kjeldsen SE, Eide I. Cardiovascular reactivity, coronary risk factors, and sympathetic activity in young men. Hypertension 1993; 22: 891-9.
20. Moan A, Nordby G, Rostrup M, Eide I, Kjeldsen SE. Insulin sensitivity, sympathetic activity, and cardiovascular reactivity in young men. Am J Hypertens 1995; 8: 268-75.
21. Fossum E, Høieggen A, Moan A, Rostrup M, Kjeldsen SE. Insulin sensitivity is related to physical fitness and exercise blood pressure to structural vascular properties in young men. Hypertension 1999; 33: 781-6.
22. De Fronzo R, Tobin J, Andres R. Glucose clamp technique. A method for quantifying insulin secretion and resistance. Am J Physiol 1990; 237: E214-23.
23. Hokanson DE, Sumner DS, Strandness DE. An electrically calibrated plethysmograph for direct measurement of limb blood flow. IEEE Trans Biomed Eng 1975; 221: 25-9.
24. Altman DG. Practical statistics for medical research. London: Chapman & Hall; 1991: 433.
25. Moan A, Høieggen A, Nordby G, Birkeland K, Eide I, Kjeldsen SE. The glucose clamp procedure activates the sympathetic nervous system even in the abscence of hyperinsulinemia. J Clin Endocrinol Metab 1995; 80: 3151-4.
26. Petrie JR, Ueda S, Morris AD, Elliot HL, Connell MC. Potential confounding effect of hand-warming on the measurement of insulin sensitivity. Clin Sci 1996; 91: 65-71.
27. Fossum E, Høieggen A, Moan A, Rostrup M, Nordby G, Kjeldsen SE. Relationship between insulin sensitivity and maximal forearm blood flow in young men. Hypertension 1998; 32: 838-43.
28. Siggard-Anderson J. Venous occlusion plethysmography on the calf. Dan Med Bull 1970; 17: 1-68.