Occlusions of epicardial arteries might not directly Induce symptoms in ischemic heart disease

Medical Hypotheses

Volumn 53, Issue 6, 1999, Pages 533-542

  Hellstrom, H R ^a  

^a State University of New York Upstate Medical University: College of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; CHOLESTEROL;

ARTERY OCCLUSION; ARTERY SPASM; ARTERY THROMBOSIS; CHOLESTEROL BLOOD LEVEL; CORONARY ARTERY DISEASE; EPICARDIUM; HEART INFARCTION; HUMAN; ISCHEMIC HEART DISEASE; PRIORITY JOURNAL; RESISTANCE BLOOD VESSEL; REVIEW; SYMPTOM;

EID: 0033383636     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1054/mehy.1999.0807     Document Type: Article

References (104)

1. Hellstrom H. R. Vasospasm in ischemic heart disease - a hypothesis. Perspect Biol Med. 16:1973;427-440.
2. Hellstrom H. R. The spasm of resistance vessel concept of ischemic heart disease and other ischemic diseases. Med Hypotheses. 33:1990;31-41.
3. Hellstrom H. R. Evidence in support of the spasm of resistance vessel concept of ischemic heart disease: an update in 1993. Med Hypotheses. 41:1993;11-22.
4. Branwood A. W., Montgomery G. L. Observations on the morbid anatomy of coronary artery disease. Scott Med J. 1:1956;367-375.
5. Chandler A. B., Chapman I., Erhardt L. R. Coronary thrombosis in myocardial infarction: report of a workshop on the role of coronary thrombosis in the pathogenesis of acute myocardial infarction. Am J Cardiol. 34:1974;823-833.
6. Spain D. M., Bradess V. A. Sudden death from coronary heart disease: survival time, frequency of thrombi, and cigarette smoking. Chest. 58:1970;107-110.
7. Warnes C. A., Roberts W. C. Sudden coronary death: comparison of patients with to those without coronary thrombus at necropsy. Am J Cardiol. 54:1984;1206-1211.
8. Roberts W. C., Buja L. M. The frequency and significance of coronary arterial thrombi and other observations in fatal acute myocardial infarction: a study of 107 necropsy patients. Am J Med. 52:1972;425-443.
9. Silver M. L., Baroldi G., Mariani F. The relationship between acute occlusive coronary thrombi and myocardial infarction studied in 100 consecutive patients. Circulation. 61:1980;219-227.
10. Baroldi G. Coronary thrombosis: facts and beliefs. Am Heart J. 91:1976;683-688.
11. Ehrlich J. C., Shinohara Y. Low incidence of coronary thrombosis in myocardial infarction: a restudy by serial block technique. Arch Path. 78:1964;432-445.
12. 125I-labelled fibrinogen into coronary arterial thrombi in acute myocardial infarction in man. Lancet. 1:1973;387-390.
13. Hellstrom H. R. Coronary artery stasis after induced myocardial infarction in the dog. Cardiovasc Res. 5:1971;371-375.
14. Farb A., Tang A. L., Burke A. P., Sessums L., Liang Y., Virmani R. Sudden coronary death: frequency of active coronary lesions, inactive coronary lesions, and myocardial infarction. Circulation. 92:1995;1701-1709.
15. Davies M. J. Anatomic features in victims of sudden coronary death: coronary artery pathology. Circulation. 85:1992;I-19-24.
16. Chapman I. The cause-effect relationship between recent coronary occlusion and acute myocardial infarction. Am Heart J. 87:1974;267-271.
17. Davies M. J., Woolf N., Robertson W. B. Pathology of acute myocardial infarction with particular reference to occlusive coronary thrombi. Br Heart J. 38:1976;659-664.
18. Falk E. Plaque rupture with severe pre-existing stenosis precipitating coronary thrombosis: characteristics of coronary atherosclerotic plaques underlying fatal occlusive thrombi. Br Heart J. 50:1983;127-134.
19. Willerson J. T., Campbell W. B., Winniford M. D. Conversion from chronic to acute coronary artery disease: speculation regarding mechanisms. Am J Cardiol. 54:1984;1349-1354.
20. Fuster V., Badimon L., Badimon J. J., Chesebro J. H. The pathogenesis of coronary artery disease and the acute coronary syndromes. N Engl J Med. 326:1992;242-250.
21. Falk E., Shah P. K., Fuster V. Coronary plaque disruption. Circulation. 92:1995;657-671.
22. DeWood M. A., Stifter W. F., Simpson C. S. Coronary arteriographic findings soon after non-Q-wave myocardial infarction. N Engl J Med. 315:1986;417-423.
23. Friedman M., Manwaring J. H., Rosenman R. H., Donlon G., Ortega P., Grube S. M. Instantaneous and sudden deaths: clinical and pathological differentiation in coronary artery disease. JAMA. 225:1973;1319-1328.
24. Myers A., Dewar H. A. Circumstances attending 100 sudden deaths from coronary artery disease with coroner's necropsies. Br Heart J. 37:1975;1133-1143.
25. Collins R., Peto R., Baigent C., Sleight P. Aspirin, heparin, and fibrinolytic therapy in suspected acute myocardial infarction. N Engl J Med. 336:1997;847-860.
26. Mehta J. L., Nichols W. W., Saldeen T. G. P. Effects of peptide 6A on coronary blood flow dynamics in canine coronary thrombosis. J Cardiovasc Pharmacol. 13:1989;803-811.
27. Gryglewski R. J. Interactions between nitric oxide and prostacyclin. Semin Thromb Hemost. 19:1993;158-166.
28. Darius H., Yanagisawa A., Brezinski M. E., Hock C. E., Lefer A. M. Beneficial effects of tissue-type plasminogen activator in acute myocardial ischemia in cats. J Am Coll Cardiol. 8:1986;125-131.
29. Hellstrom H. R. Myocardial reperfusion injury: an assessment by the spasm of resistance vessel concept of ischemic heart disease. Med Hypotheses. 33:1990;117-124.
30. Olafsson B., Forman M. B., Puett D. W. Reduction of reperfusion injury in the canine preparation by intracoronary adenosine: importance of the endothelium and the no-reflow phenomenon. Circulation. 76:1987;1135-1145.
31. Kagan A., Livsic A. M., Sternby N., Vihert A. M. Coronary-artery thrombosis and the acute attack of coronary heart-disease. Lancet. 2:1968;1199-1202.
32. Gross H., Sternberg W. H. Myocardial infarction without significant lesions of the coronary arteries. Arch Int Med. 64:1939;249-267.
33. Cannon R. O. III, Watson R. M., Rosing D. R., Epstein S. E. Angina caused by reduced vasodilator reserve of the small coronary arteries. J Am Coll Cardiol. 1:1983;1359-1373.
34. Mallory G. K., White P. D., Salcedo-Salgar J. The speed of healing of myocardial infarction: a study of the pathologic anatomy in seventy-two cases. Am Heart J. 18:1939;647-671.
35. Ridker P. M., Cushman M., Stampfer M. J., Tracy R. P., Hennekens C. H. Inflammation, aspirin, and the risk of cardidovascular disease in apparently healthy men. N Engl J Med. 336:1997;973-979.
36. van der Wal A. C., Becker A. E., van der Loos C. M., Das P. K. Site of intimal rupture or erosion of thrombosed coronary atherosclerotic plaques is characterized by an inflammatory process irrespective of the dominant plaque morphology. Circulation. 89:1994;36-44.
37. Casscells W., Hathorn B., David M. Thermal detection of cellular infiltrates in living atherosclerotic plaques: possible implications for plaque rupture and thrombosis. Lancet. 347:1996;1447-1449.
38. Buja L. M. Does atherosclerosis have an infectious etiology? Circulation. 94:1996;872-873.
39. Ross R. Atherosclerosis: a defense mechanism gone awry. Am J Pathol. 143:1993;987-1002.
40. Campbell W. B., Halushka P. V. Lipid-derived autacoids: eicosanoids and platelet-activating factor. Hardman J. G., Limbird L. E., Molinoff P. B., Ruddon R. W. The Pharmacological Basis of Therapeutics. 1996;601-616 McGraw-Hill, New York.
41. Klemm P., Warner T. D., Corder R., Vane J. R. Endothelin-1 mediates coronary vasoconstriction caused by exogenous and endogenous cytokines. J Cardiovasc Pharmacol. 26:1995;S419-421.
42. Ito A., Shimokawa H., Fukumoto Y. The role of fibroblast growth factor-2 in the vascular effects of interleukin-1b in porcine coronary arteries in vivo. Cardiovasc Res. 32:1996;570-579.
43. Shepherd J., Cobbe S. M., Ford I. Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia: West of Scotland Coronary Prevention Study Group. N Engl J Med. 333:1995;1301-1307.
44. Circulation. 89:1994;1333-1445.
45. Gould K. L., Ornish D., Kirkeeide R. Improved stenosis geometry by quantitative coronary arteriography after vigorous risk factor modification. Am J Cardiol. 69:1992;845-853.
46. Brown B. G., Zhao X. Q., Sacco D. E., Albers J. J. Lipid lowering and plaque regression: new insights into prevention of plaque disruption and clinical events in coronary disease. Circulation. 87:1993;1781-1791.
47. Brown G., Albers J. J., Fisher L. D. Regression of coronary artery disease as a result of intensive Lipid-lowering therapy in men with high levels of apolipoprotein B. N Engl J Med. 323:1990;1289-1298.
48. Jukema J. W., Bruschke A. V. G., van Boven A. J. Effects of lipid lowering by pravastatin on progression and regression of coronary artery disease in symptomatic men with normal to moderately elevated serum cholesterol levels: the Regression Growth Evaluation Statin Study (REGRESS). Circulation. 91:1995;2528-2540.
49. Weintraub W. S., Pederson T. R. Atherosclerosis and restenosis: reflections on the Lovastatin Restenosis Trial and Scandinavian Simvastatin Survival Study. Am J Cardiol. 78:1996;1036-1038.
50. de Divitiis M., Rubba P., Di Somma S. Effects of short-term reduction in serum cholesterol with simvastatin in patients with stable angina pectoris and mild to moderate hypercholesterolemia. Am J Cardiol. 78:1996;763-768.
51. Sellke F. W., Armstrong M. L., Harrison D. G. Endothelium- dependent vascular relaxation is abnormal in the coronary microcirculation of atherosclerotic primates. Circulation. 81:1990;1586-1593.
52. Muller J. E., Abela G. S., Nesto R. W., Tofler G. H. Triggers, acute risk factors and vulnerable plaques: the lexicon of a new frontier. J Am Coll Cardiol. 23:1994;809-813.
53. Fox K., Mulcahy D., Keegan J., Wright C. Circadian patterns of myocardial ischemia. Am Heart J. 118:1989;1084-1086.
54. Buff D. D., Fleisher J. M., Roca J. A., Jaffri M., Wyrwinski P. M. Circadian distribution of in-hospital cardiopulmonary arrests on the general medical ward. Arch Intern Med. 152:1992;1282-1288.
55. Cannon C. P., McCabe C. H., Stone P. H. Circadian variation in the onset of unstable angina and non-Q-wave acute myocardial infarction (the TIMI III Registry and TIMI IIIB). Am J Cardiol. 79:1997;253-258.
56. Levy R. D., Cunningham D., Shapiro L. M., Wright C., Mockus L., Fox K. M. Diurnal Variation in left ventricular function: a study of patients with myocardial ischaemia, syndrome X, and of normal controls. Br Heart J. 57:1987;148-153.
57. Tofler G. H., Muller J. E., Stone P. H. Modifiers of timing and possible triggers of acute myocardial infarction in the Thrombolysis in Myocardial Infarction Phase II (TIMI II) Study Group. J Am Coll Cardiol. 20:1992;1049-1055.
58. Muller J. E., Ludmer P. L., Willich S. N. Circadian variation in the frequency of sudden cardiac death. Circulation. 75:1987;131-138.
59. Panza J. A., Epstein S. E., Quyyumi A. A. Circadian variation in vascular tone and its relation to a-sympathetic vasoconstrictor activity. N Engl J Med. 325:1991;986-990.
60. Fujita M., Franklin D. Diurnal changes in coronary blood flow in conscious dogs. Circulation. 76:1987;488-491.
61. Brezinski D. A., Tofler G. H., Muller J. E. Morning increase in platelet aggregability: association with assumption of the upright posture. Circulation. 78:1988;35-40.
62. L'Abbate A., Simonetti I., Carpeggiani C., Michelassi C. Coronary dynamics and mental arithmetic stress in human. Circulation. 83:1991;94-99.
63. Rozanski A., Bairey C. N., Krantz D. S. Mental stress and the induction of silent myocardial ischemia in patients with coronary artery disease. N Engl J Med. 318:1988;1005-1012.
64. Frasure-Smith N., Prince R. Long-term follow-up of the Ischemic Heart Disease Life Stress Monitoring Program. Psychosom Med. 51:1989;485-513.
65. Reich P., DeSilva R. A., Lown B., Murawski B. J. Acute psychological disturbances preceding life-threatening ventricular arrhythmias. JAMA. 246:1981;233-235.
66. Lown B. Sudden cardiac death: biobehavioral perspective. Circulation. 76:1987;186-196.
67. Shepherd J. T., Dembroski T. M., Brody M. J. Task Force 3: biobehavioral mechanisms in coronary artery disease: acute stress. Circulation. 76:1987;150-157.
68. Grignani G., Soffiantino F., Zucchella M. Platelet activation by emotional stress in patients with coronary artery disease. Circulation. 83:1991;128-136.
69. Weiner D. A., Ryan T. J., McCabe C. H. The role of exercise-induced silent myocardial ischemia in patients with abnormal left ventricular function: a report from the Coronary Artery Surgery Study (CASS) registry. Am Heart J. 118:1989;649-654.
70. Mittleman M. A., Maclure M., Tofler G. H., Sherwood J. B., Goldberg R. J., Muller J. E. Triggering of acute myocardial infarction by heavy physical exertion: protection against triggering by regular exertion. N Engl J Med. 329:1993;1677-1683.
71. Siscovick D. S., Weiss N. S., Fletcher R. H., Lasky T. The incidence of primary cardiac arrest during vigorous exercise. N Engl Med. 311:1984;874-877.
72. Hoberg E., Schuler G., Kunze B. Silent myocardial ischemia as a potential link between lack of premonitoring symptoms and increased risk of cardiac arrest during physical stress. Am J Cardiol. 65:1990;583-589.
73. Frick M. H. The effect of physical training in manifest ischemic heart disease. Circulation. 40:1969;433-435.
74. Hull S. S. Jr, Vanoli E., Adamson P. B., Verrier R. L., Foreman R. D., Schwartz P. J. Exercise training confers anticipatory protection from sudden death during acute myocardial ischemia. Circulation. 89:1994;548-452.
75. Hellstrom H. R. Mechanism of exercise training in protecting from sudden cardiac death during exertion [letter]. Circulation. 90:1994;2564.
76. Ornish D., Scherwitz L. W., Doody R. S. Effects of stress management training and dietary changes in treating ischemic heart disease. JAMA. 249:1983;54-59.
77. Gould K. L., Martucci J. P., Goldberg D. I. Short-term cholesterol lowering decreases size and severity of perfusion abnormalities by positron emission tomography after dipyridamole in patients with coronary artery disease: a potential noninvasive marker of healing coronary endothelium. Circulation. 89:1994;1530-1538.
78. Ornish D., Brown S. E., Scherwitz L. W. Can lifestyle changes reverse coronary heart disease? The Lifestyle Heart Trial. Lancet. 336:1990;129-133.
79. van Boven A. J., Jukema J. W., Zwinderman A. H., Crijns H. J.G.M., Lie K. I., Bruschke A. V.G. Reduction of transient myocardial ischemia with pravastatin in addition to the conventional treatment in patients with angina pectoris. Circulation. 94:1996;1503-1505.
80. Grayson J., Lapin B. A. Observations on the mechanisms of infarction in the dog after experimental occlusion of the coronary artery. Lancet. 1:1966;1284-1288.
81. Eng C., Cho S., Factor S. M., Sonnenblick E. H., Kirk E. S. Myocardial micronecrosis produced by microsphere embolization: role of an a-adrenergic tonic influence on the coronary microcirculation. Circ Res. 54:1984;74-82.
82. Karmazyn M., Horrobin D. F., Oka M. Changes in coronary vascular resistance with prolonged hypoxia in isolated rat hearts: a possible role of prostaglandins. Life Sci. 25:1979;1991-1999.
83. Heusch G., Deussen A., Thämer V. Cardiac sympathetic nerve activity and progressive vasoconstriction distal to coronary stenoses: feed-back aggravation of myocardial ischemia. J Auton Nerv Syst. 13:1985;311-326.
84. Gorman M. W., Sparks H. V. Jr. Progressive coronary vasoconstriction during relative ischemia in canine myocardium. Circ Res. 51:1982;411-420.
85. Weber K. T., Janicki J. S. The metabolic demand and oxygen supply of the heart: physiologic and clinical considerations. Am J Cardiol. 44:1979;722-729.
86. Oliva P. B., Breckinridge J. C. Arteriographic evidence of coronary arterial spasm in acute myocardial infarction. Circulation. 56:1977;366-374.
87. Kaski J. C., Crea F., Meran D. Local coronary supersensitivity to diverse vasoconstrictive stimuli in patients with variant angina. Circulation. 74:1986;1255-1265.
88. Brush J. E. Jr, Cannon R. O. III, Schenke W. H. Angina due to coronary microvascular disease in hypertensive patients without left ventricular hypertrophy. N Engl J Med. 319:1988;1302-1307.
89. Yamakado T., Kecheng X., Masusda T., Nakano T., Takezawa H. Disappearance of coronary collateral vessels as a mechanism of vasospastic angina. Am Heart J. 117:1989;1379-1381.
90. Serota H., Kern M. J., Deligonul U., Aguirre F., Caralis D. G. Ergonovine-induced myocardial ischemia without epicardial coronary vasospasm: evidence for ischemia produced by small-vessel vasoconstriction. Am Heart J. 121:1991;1807-1809.
91. Maseri A. Role of coronary artery spasm in symptomatic and silent myocardial ischemia. J Am Coll Cardiol. 9:1987;249-262.
92. Specchia G., de Servi S., Falcone C. Coronary arterial spasm as a cause of exercise-induced ST-segment elevation in patients with variant angina. Circulation. 59:1979;948-954.
93. Selwyn A. P., Fox K., Clay T. The effect of acute regional myocardial ischemia on the angiographic anatomy of coronary arteries. Circulation. 60:1979;1335-1342.
94. Panza J. A., Garcia C. E., Kilcoyne C. M., Quyyumi A. A., Cannon R. O. III. Impaired endothelium-dependent vasodilation in patients with essential hypertension: evidence that nitric oxide abnormality is not localized to a single signal transduction pathway. Circulation. 91:1995;1732-1738.
95. Kiowski W., Linder L., Stoschitzky K. Diminished vascular response to inhibition of endothelium-derived nitric oxide and enhanced vasoconstriction to exogenously administered endothelin-1 in clinically healthy smokers. Circulation. 90:1994;27-34.
96. Diederich D., Skopec J., Diederich A., Dai F. X. Endothelial dysfunction in mesenteric resistance arteries of diabetic rats: role of free radicals. Am J Physiol. 266:1994;H1153-1161.
97. Mayhan W. G., Faraci F. M., Baumbach G. L., Heistad D. D. Effects of aging on responses of cerebral arterioles. Am J Physiol. 258:1990;H1138-1143.
98. Havranek E. P., Nademanee K., Grayburn P. A., Eichhorn E. J. Endothelium-dependent vasorelaxation is impaired in cocaine arteriopathy. J Am Coll Cardiol. 28:1996;1168-1174.
99. Pupita G., Maseri A., Kaski J. C. Myocardial ischemia caused by distal coronary-artery constriction in stable angina pectoris. N Engl J Med. 323:1990;514-520.
100. Pemberton M., Anderson G., Barker J. In vivo microscopy of microcirculatory injury in skeletal muscle following ischemia/reperfusion. Microsurgery. 15:1994;374-382.
101. Piana R. N., Paik G. Y., Moscucci M. Incidence and treatment of 'no-reflow' after percutaneous coronary intervention. Circulation. 89:1994;2514-2518.
102. Hellstrom H. R. New evidence for the spasm of resistance vessel concept of ischemic diseases. Med Hypothese. 53:1999;200-209.
103. Lamont N. M., Posel K. The coronary attack: concepts on its etiology and hemodynamic management. Am Heart J. 78:1969;480-492.
104. Eliot R. S., Holsinger J. W. Jr. A unified concept of the pathophysiology of myocardial infarction and sudden death. Chest. 62:1972;469-474.