Comparison of once and twice daily dosing of didanosine in combination with stavudine for the treatment of HIV-1 infection

Antiviral Therapy

Volumn 4, Issue 4, 1999, Pages 195-202

  Monno, Laura ^a   Cargnel, Antonietta ^b   Soranzo, Maria Luisa ^c   Chirianni, Antonio ^d   Ferraro, Teresa ^e   Di Stefano, Mariantonietta ^a   Angarano, Gioacchino ^a  

^a UNIVERSITY OF BARI   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c AMEDEO DI SAVOIA HOSPITAL   (Italy)

^d AO Dei Colli Hospital for Infectious Diseases D Cotugno   (Italy)

^e PUGLIESE CIACCIO HOSPITAL   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIRETROVIRUS AGENT; CD4 ANTIGEN; DIDANOSINE; STAVUDINE; VIRUS RNA;

ADULT; ANTIVIRAL ACTIVITY; ARTICLE; CLINICAL TRIAL; COMPARATIVE STUDY; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; GASTROINTESTINAL SYMPTOM; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; LYMPHOCYTE COUNT; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NEUROLOGIC DISEASE; NEUTROPENIA; PRIORITY JOURNAL; SIDE EFFECT; TIME;

ADULT; AGED; ANTI-HIV AGENTS; CD4 LYMPHOCYTE COUNT; DIDANOSINE; DRUG THERAPY, COMBINATION; FEMALE; HIV INFECTIONS; HIV-1; HUMANS; MALE; MIDDLE AGED; REVERSE TRANSCRIPTASE INHIBITORS; RISK FACTORS; RNA, VIRAL; STAVUDINE;

EID: 0033382971     PISSN: 13596535     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (5)

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2. Ahluwalia G, Cooney DA, Hartman NR, Mitsuya H, Yarchoan R, Fridland A, Broder S & Johns DG. Anomalous accumulation and decay of 2′,3′-dideoxyadenosine-5′-triphosphate in human T-cell cultures exposed to the anti-HIV drug 2′,3′-dideoxyadenosine. Drug Metabolism and Disposition 1993; 21:369-376.
3. Hoetelmans RM, van Heeswijk RP, Profijt M, Mulder JW, Meenhorst PL, Lange JM, Reiss P & Beijnen JH. Comparison of the plasma pharmacokinetics and renal clearance of didanosine during once and twice daily dosing in HIV-1 infected individuals. AIDS 1998; 12:F211-216.
4. Cooley TP, Kunches LM, Saunders CA, Perkins CJ, Kelley SL, McLaren C, McCaffrey RP & Liebman HA. Treatment of AIDS and AIDS-related complex with 2′,3′-dideoxyadenosine given once daily. Reviews of Infectious Diseases 1990; 16:5552-5560.
5. Liebman HA & Cooley TP. Didanosine in the treatment of AIDS and AIDS-related complex: a critical appraisal of the dose and frequency of administration. Clinical Infections Diseases 1993; 16 (Suppl. 1):S52-S58.