A simpler model of the human circadian pacemaker

Journal of Biological Rhythms

Volumn 14, Issue 6, 1999, Pages 532-537

  Forger, Daniel B ^a   Jewett, Megan E ^b   Kronauer, Richard E ^a,b  

^a HARVARD UNIVERSITY   (United States)

^b Circadian   (United States)

Author keywords

Amplitude; Biological rhythms; Bright light; Human circadian pacemaker; Model; Van der Pol oscillator

Indexed keywords

ALGORITHM; BIOLOGICAL MODEL; BIOLOGICAL RHYTHM; CIRCADIAN RHYTHM; COMPUTER SIMULATION; CONFERENCE PAPER; HUMAN; NASA DISCIPLINE REGULATORY PHYSIOLOGY; NON-NASA CENTER; PHOTOSTIMULATION; PHYSIOLOGY;

NASA DISCIPLINE REGULATORY PHYSIOLOGY; NON-NASA CENTER;

ALGORITHMS; BIOLOGICAL CLOCKS; CIRCADIAN RHYTHM; COMPUTER SIMULATION; HUMANS; MODELS, BIOLOGICAL; PHOTIC STIMULATION;

EID: 0033382102     PISSN: 07487304     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (16)

1. Acherman P and Kunz H (1999) Modeling circadian rhythm generation in the suprachiasmatic nucleus with locally coupled self-sustained oscillators: Phase shifts and phase response curves. J Biol Rhythms 14:460-468.
2. Aschoff J (1960) Exogenous and endogenous components in circadian rhythms. Cold Spring Harb Symp Quant Biol 25:11-28.
3. Brown EN, Choe Y, and Czeisler CA (1995) Statistical analysis of human core-temperature rhythms with differential equation methods. Bio Rhy Res 26:372.
4. Czeisler CA, Duffy JF, Shanahan TL, Brown EN, Mitchell JF, Rimmer DW, Ronda JM, Silva EJ, Allan JS, Emens JS, Dijk D-J, and Kronauer RE (1999) Stability, precision, and near-24-hour period of the human circadian pacemaker. Science 284:2177-2181.
5. Gundel A and Spencer M (1999) A circadian oscillator model based on empirical data. J Biol Rhythms 14:516-523.
6. Jewett ME, Forger DB, and Kronauer RE (1999) Revised limit cycle oscillator model of the human circadian pacemaker. J Biol Rhythms 14: 493-499.
7. Jewett ME and Kronauer RE (1998) Refinement of a limit cycle oscillator model of the effects of light on the human circadian pacemaker. J Theor Biol 192:455-465.
8. Jewett ME, Kronauer RE, and Czeisler CA (1991) Light-induced suppression of endogenous circadian amplitude in humans. Nature 350:59-62.
9. Jewett ME, Kronauer RE, and Czeisler CA (1994) Phase/ amplitude resetting of the human circadian pacemaker via bright light: A further analysis. J Biol Rhythms 9: 295-314.
10. Khalsa SBS, Jewett ME, Klerman EB, Duffy JF, Rimmer DW, Kronauer RE, and Czeisler CA (1997) Type O resetting of the human circadian pacemaker to consecutive bright light pulses against a background of very dim light. Sleep Res 26:722.
11. Klerman EB, Dijk D-J, Kronauer RE, and Czeisler CA (1996) Simulations of effects of light on the human circadian pacemaker: Implications for assessment of intrinsic period. Am J Physiol 270:R271-R282.
12. Kronauer RE (1990) A quantitative model for the effects of light on the amplitude and phase of the deep circadian pacemaker, based on human data. In Sleep '90, Proceedings of the Tenth European Congress on Sleep Research, J Horne, ed, pp 306-309, Pontenagel Press, Dusseldorf.
13. Kronauer RE, Czeisler CA, Pilato SF, Moore-Ede MC, and Weitzman ED (1982) Mathematical model of the human circadian system with two interacting oscillators. Am J Physiol 242:R3-R17.
14. Kronauer RE, Forger DB, and Jewett ME (1999) Quantifying human circadian pacemaker response to brief, extended, and repeated light episodes over the photopic range. J Biol Rhythms 14:500-515.
15. Sanders JA and Verhulst F (1985) Averaging Methods in Non-linear Dynamical Systems, Springer-Verlag, New York.
16. Wever R (1972) Virtual synchronization towards the limits of the range of entrainment. J Theor Biol 36:119-132.