Cardiac arrhythmia at high altitude: The progressive effect of aging

Texas Heart Institute Journal

Volumn 26, Issue 4, 1999, Pages 258-263

  Alexander, James K ^a,b  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b MICHAEL E DEBAKEY VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Age factors; Altitude; Arrhythmia; Hypoxia; Mountaineering

Indexed keywords

OXYGEN;

AGED; AGING; ALTITUDE; ARTERIAL OXYGEN SATURATION; ARTICLE; CASE REPORT; ECHOCARDIOGRAPHY; ELECTROCARDIOGRAPHY; HEART ARRHYTHMIA; HEART RATE; HUMAN; MALE; OXIMETRY;

AGED; AGING; ALTITUDE; ELECTROCARDIOGRAPHY, AMBULATORY; HEART CONDUCTION SYSTEM; HEART FUNCTION TESTS; HUMANS; MALE; OXYGEN; TACHYCARDIA, VENTRICULAR; VENTRICULAR PREMATURE COMPLEXES;

EID: 0033379499     PISSN: 07302347     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Aigner A, Berghold F, Muss N. [Investigations on the cardiovascular system at altitudes up to a height of 7,800 meters]. German. Z Kardiol 1980;69:604-10.
2. Milledge JS. Electrocardiographic changes at high altitude. Br Heart J 1963;25:291-8.
3. Das BK, Tewari SC, Parashar SK, Akhtar M, Grover DN, Ohri VC, et al. Electrocardiographic changes at high altitude. Indian Heart J 1983;35:30-3.
4. Forster P. Telescopes in high places. In: Heath D, ed. Aspects of hypoxia. Liverpool: Liverpool University Press, 1986:225-6.
5. Ichimaru Y, Utsunomiya T, Kodama Y, Sato Y, Yanaga T. Electrocardiographic changes during physical activities under simulated altitude of 5500 m. In: Ueda G, Kusama S, Voelkel NF, eds. High altitude medical science. Matsumoto, Japan: Shinshu University, 1988:209-13.
6. Malconian M, Rock P, Hultgren H, Donner H, Cymerman A, Groves B, et al. The electrocardiogram at rest and exercise during a simulated ascent of Mt. Everest (Operation Everest II). Am J Cardiol 1990;65:1475-80.
7. Alexander JK. Age, altitude, and arrhythmia. Tex Heart Inst J 1995;22:308-16.
8. Groves BM, Reeves JT, Sutton JR, Wagner PD, Cymerman A, Malconian MK, et al. Operation Everest II: elevated high-altitude pulmonary resistance unresponsive to oxygen. J Appl Physiol 1987;63:521-30.
9. Dill DB, Hillyard SD, Miller J. Vital capacity, exercise performance, and blood gases at altitude as related to age. J Appl Physiol 1980;48:6-9.
10. Jackson F, Davies H. The electrocardiogram of the mountaineer at high altitude. Br Heart J 1960;22:671-85.
11. Harris CW, Hansen JE. Electrocardiographic changes during exposure to high altitude. Am J Cardiol 1966;18:183-90.
12. Shi ZY, Ning XH, Zhu SC, Zhao DM, Huang PG, Yang SY, et al. Electrocardiogram made on ascending the Mount Qomolangma from 50 m a.s.l. Sci Sin 1980;23:1316-25.
13. Akhtar M, Bandopadhaya P, Chatterjee PC, Krishnamurti S. Electrocardiographic changes under moderate hypoxia. Indian Heart J 1979;31:353-8.
14. Rowell LB, Johnson DG, Chase PB, Comess KA, Seals DR. Hypoxemia raises muscle symparhetic activity but not norepinephrine in resting humans. J Appl Physiol 1989; 66: 1736-43.
15. Seals DR, Johnson DG, Fregosi RF. Hypoxia potentiates exercise-induced sympathetic neural activation in humans. J Appl Physiol 1991;71:1032-40.
16. Wit AL, Rosen MR. Pathophysiologic mechanisms of cardiac arrhythmias. Am Heart J 1983;106(4 Pt 2):798-811.
17. Wellens HJJ, Gorgels APM, Rodriguez LM, Vos MA, Smeets JLRM. Supraventricular tachycardias: mechanisms, electrocardiographic manifestations, and clinical aspects. In: Josephson ME, Wellens HJJ, editors. Tachycardias: mechanisms and management. Mt. Kisco, New York: Futura Publishing Company, Inc., 1993:122.
18. Fleg JL. Ventricular arrhythmias in the elderly: prevalence, mechanisms, and therapeutic implications. Geriatrics 1988;43:23-9
19. Fleg JL, Tzankoff SP, Lakatta EG. Age-related augmentation of plasma catecholamines during dynamic exercise in healthy males. J Appl Physiol 1985;59:1033-9.
20. Folkow B, Svanborg A. Physiology of cardiovascular aging. Physiol Rev 1993;73:725-64.
21. Vestal RE, Wood AJ, Shand DG. Reduced beta-adrenoceptor sensitivity in the elderly. Clin Pharmacol Ther 1979; 26: 181-6.
22. Docherty JR, Hyland L. Aging and α-adrenoceptor function [letter]. Trends Pharmacol Sci 1986;7:131-2.
23. Fedida D, Braun AP, Giles WR. Alpha 1-adrenoceptors in myocardium: functional aspects and transmembrane signaling mechanisms. Physiol Rev 1993;73:469-87.
24. del Balzo U, Rosen MR, Malfatto G, Kaplan LM, Steinberg SF. Specific alpha 1-adrenergic receptor subtypes modulate catecholamine-induced increases and decreases in ventricular automaticity. Circ Res 1990;67:1535-51.
25. Malconian M, Hultgren H, Nitta M, Anholm J, Houston C, Fails H. The sleep electrocardiogram at extreme altitudes. Am J Cardiol 1990;65:1014-20.
26. Burtscher M, Philadelphy M, Likar R. Sudden cardiac death during mountain hiking and downhill skiing [letter]. New Engl J Med 1993;329:1738-9.
27. Burtscher M, Philadelphy M, Nachbauer W, Likar R. The risk of death to trekkers and hikers in the mountains [letter]. JAMA 1995;273:460.
28. Burtscher M. Time-dependent SCD risk during mountain hiking [letter]. Circulation 1994;89:2948-9.
29. Pollard A, Clarke C. Deaths during mountaineering at extreme altitude [letter]. Lancet 1988;1:1277.