Dose-response relationships in chemical carcinogenesis reflect differences in individual susceptibility. Consequences for cancer risk assessment, extrapolation, and prevention

Human and Experimental Toxicology

Volumn 18, Issue 12, 1999, Pages 707-712

  Lutz, W K ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Cancer; Carcinogen; Dose; Individual; Risk; Susceptibility

Indexed keywords

CARCINOGEN; DNA;

CANCER; CANCER PREVENTION; CANCER RISK; CANCER SUSCEPTIBILITY; CELL HYPERPLASIA; CELL METABOLISM; CHEMICAL CARCINOGENESIS; CYTOTOXICITY; DATA ANALYSIS; DNA REPAIR; DOSE RESPONSE; GENOTOXICITY; HUMAN; LIFESTYLE; NONHUMAN; PRIORITY JOURNAL; REVIEW; RISK ASSESSMENT; RISK FACTOR;

ANIMALIA;

EID: 0033379399     PISSN: 09603271     EISSN: None     Source Type: Journal    
DOI: 10.1191/096032799678839653     Document Type: Review

References (8)

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3. Lutz WK. Endogenous genotoxic agents and processes as a basis of spontaneous carcinogenesis. Mutat Res 1990; 238: 287-295.
4. Gupta RC, Lutz WK. Background DNA damage from endogenous and unavoidable exogenous carcinogens: a basis for spontaneous cancer incidence? Mutat Res 1999; 424: 1-8.
5. Lutz WK, Gaylor D. Significance of DNA adducts at low dose: shortening the time to spontaneous tumor occurrence. Regul Toxicol Pharmacol 1996; 23: 29-34.
6. Lutz WK. Carcinogens in the diet vs. overnutrition. Individual dietary habits, malnutrition, and genetic susceptibility modify carcinogenic potency and cancer risk. Mutat Res 1999; 443: 251-258.
7. Zeise L, Wilson R, Crouch EAC. Dose-response relationships for carcinogens: a review. Environ Health Perspect 1987; 73: 259-308.
8. Druckrey H et al. Quantitative Analyse der carcinogenen Wirkung von Diäthylnitrosamin. Arzneim Forsch 1963; 13: 841-851.