Chronic rejection: The result of uncontrolled remodelling of graft tissue by recipient mesenchymal cells? Data from two rodent models and the effects of immunosupressive therapies

Inflammation Research

Volumn 48, Issue SUPPL. 2, 1999, Pages

  Brazelton, T R ^a   Adams, B ^a   Shorthouse, R ^a   Morris, R E ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

15 DEOXYSPERGUALIN; CYCLOSPORIN A; LEFLUNOMIDE; MYCOPHENOLIC ACID; RAPAMYCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; CELL INFILTRATION; CELL PROLIFERATION; CHRONIC DISEASE; CONFERENCE PAPER; DRUG MECHANISM; GRAFT REJECTION; IMMUNOSUPPRESSIVE TREATMENT; MESENCHYME CELL; NONHUMAN; RAT;

EID: 0033378401     PISSN: 10233830     EISSN: None     Source Type: Journal    
DOI: 10.1007/s000110050554     Document Type: Conference Paper

References (6)

1. Hosenpud JD, Bennett L, Keck BM, Fiol B, Boucek MM, Novick RJ. The Registry of the International Society for Heart and Lung Transplantation: Fifteenth official report - 1998. J Heart Lung Transplant 1998; 17: 656-68.
2. Slapak GI, Saxena R, Portmann B, Gane E, Devlin J, Calne R, et al. Graft and systemic disease in long-term survivors of liver transplantation. Hepatology 1997; 25: 195-202.
3. Kasiske BL. Clinical correlates to chronic renal allograft rejection. Kidney Int 1997; 63: S71-4.
4. Morris RE, Huang X, Gregory CR, Billingham ME, Rowan R, Shorthouse R, et al. Studies in experimental models of chronic rejection: use of rapamycin (sirolimus) and isoxazole derivatives (leflunomide and its analogue) for the suppression of graft vascular disease and obliterative bronchiolitis. Transplant Proc 1995; 27: 2068-9.
5. Gregory CR, Huang X, Pratt RE, Dzau VJ, Shorthouse R, Billingham ME, et al. Treatment with rapamycin and mycophenolic acid reduces arterial intimal thickening produced by mechanical injury and allows endothelial replacement. Transplantation 1995; 59: 655-61.
6. Brazelton TR, Adams BA, Cheung AC, Morris RE. Progression of obliterative airway disease occurs despite the removal of immune reactivity by retransplantation. Transplant Proc 1997; 29: 2613.