A novel method to produce extensive gastric antral ulcer in rats: Pharmacological factors involved in the etiology of antral ulceration

Journal of Physiology Paris

Volumn 93, Issue 5, 1999, Pages 437-442

  Uchida, Masayuki ^a,b   Takayama, Miki ^a   Kato, Yumi ^b   Tsuchiya, Shizuko ^a   Horie, Syunji ^a   Watanabe, Kazuo ^a  

^a CHIBA UNIVERSITY   (Japan)

^b Meiji Institute of Health Science   (Japan)

Author keywords

Allopurinol; Antral ulcer; Diethyldithiocarbamate (DDC); DMSO; Famotidine; GSH; HCl; Rat

Indexed keywords

ALLOPURINOL; DIETHYLDITHIOCARBAMIC ACID; DIMETHYL SULFOXIDE; FAMOTIDINE; GLUTATHIONE; HYDROCHLORIC ACID;

ANIMAL MODEL; CONFERENCE PAPER; DRUG EFFECT; MALE; NONHUMAN; RAT; STOMACH ANTRUM; STOMACH BLOOD FLOW; STOMACH SECRETION; STOMACH ULCER; ULCEROGENESIS;

EID: 0033373791     PISSN: 09284257     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-4257(99)00116-3     Document Type: Conference Paper

References (25)

1. Chen S.S., Pan S., Okita K., Takemoto T. Role of super oxide dismutase in mechanism of diethyldithiocarbamate-induced gastric antral ulcer in rats: protective effect of prostaglandin, cimetidine and pirenzepine. J. Gastroenterol. Hepatol. 8:1993;457-461.
2. Chen S.H., Pan S. Sources of superoxide radicals involved in the pathogenesis of diethyldithiocarbamate-induced gastric antral ulcer in rats. J. Formos Med. Assoc. 97:1998;131-134.
3. Clayton N.M., Orkley I., Williams L.V., Trevethick M.A. The role of acid in the pathogenesis of indomethacin-induced gastric antral ulcers in the rat. Aliment Pharmacol. Ther. 10:1996;339-345.
4. Granger D.N., McCord J.M., Parks D.A., Hollwarth M.E. Xanthine oxidase inhibitors attenuate ischemia-induced vascular permeability changes in the cat intestine. Gastroenterology. 90:1986;80-84.
5. Hirano T., Niijima A. Effects of 2-deoxy-D-glucose, glucose and insulin on efferent activity of gastric vagus nerve. Experimentia. 36:1980;1197-1199.
6. Hirschowitz B.I., Sachs G. Vagal gastric secretory stimulation by 2-deoxy-D-glucose. Am. J. Physiol. 209:1965;452-460.
7. Ishiyama H., Yamasaki K., Imaizumi T., Kanbe T., Ogino K., Oka S., Okazaki Y., Takemoto T. Gastric antral ulcer produced by diethyldithiocarbamate in rats. J. Clin. Biochem. Nutr. 5:1988;155-163.
8. Itoh M., Guth P.H. Role of oxygen-derived free radicals in hemorrhagic shock-induced gastric lesions in the rat. Gastroenterology. 88:1985;1162-1167.
9. Khalil Z., Marley P.D., Livett B.G. Elevation in plasma catecholamines in response to insulin stress is under both neuronal and nonneuronal control. Endocrinology. 119:1986;159-167.
10. Kuratani K., Yamazaki M., Kodama H., Yamaguchi I. Possible involvement of hyperinsulinemia and adrenergic activation in the pathogenesis of indomethacin-induced antral ulcers in non-fasted hamsters and refed rats. J. Pharmacol. Exp. Ther. 263:1992;951-955.
11. Maeda-Hagiwara M., Watanabe K. Gastric antral ulcers produced by the combined administration of indomethacin with 2-deoxy-D-glucose in the rat. Eur. J. Pharmacol. 89:1983;243-250.
12. Mercer S.W., Williamson D.H. Time course of changes in plasma glucose and insulin concentration and mammary gland lipogenesis during refeeding of starved conscious lactating rats. Biochem. J. 239:1986;489-492.
13. Nakamura A., Uchida M. Involvement of histamine in the mechanism of HCl-induced gastric lesions in rats. Jpn. J. Pharmacol. 76 (Suppl. 1):1998;290.
14. Niida H., Okada K., Takeuchi K., Okabe S. A new model of duodenal ulcers induced in rats by diethyldithiocarbamate, a superoxide dismutase inhibitor. Scand. J. Gastroenterol. 24 (Suppl. 162):1989;116-119.
15. Oates P.J., Hakkinen J.P. Studies on the mechanism of ethanol-induced gastric damage in rats. Gastroenterology. 94:1988;10-21.
16. Oi M., Oshida K., Sugimura S. The location of gastric ulcer. Gastroenterology. 36:1959;45-56.
17. Perry M.A., Wadhwa S., Parks D.A., Pickard W., Granger D.N. Role of oxygen radicals in ischemia-induced lesions in the cat stomach. Gastroenterology. 90:1986;362-367.
18. Satoh H., Inada I., Hirata T., Maki Y. Indomethacin produces gastric antral ulcers in the refed rat. Gastroenterology. 81:1981;719-725.
19. Takeuchi K., Takehara K., Ohuchi T. Diethyldithiocarbamate, a superoxide dismutase inhibitor, reduces indomethacin-induced gastric lesions in rats. Digestion. 57:1996;210-219.
20. Teramura S., Murakami M., Saita H., Yoo J.K., Kusaka S., Matsuo K., Kita T., Miyake T. Effect of diethyldithiocarbamate on gastric and duodenal mucosal blood flow and vascular permeability in rats. Scand. J. Gastroenterol. 24 (Suppl. 162):1989;108-111.
21. Uchida M., Yano S., Watanabe K. A reliable method for the production of antral gastric ulcer by a combination of 2-deoxy-D-glucose, aspirin and ammonia in rats. Jpn. J. Pharmacol. 56:1991;475-481.
22. Uchida M., Yano S., Watanabe K. Aggravation by the capsaicin-treatment of gastric antral ulcer induced by the combination of 2-deoxy-D-glucose, aspirin and ammonia in rats. Jpn. J. Pharmacol. 57:1991;377-385.
23. Uchida M., Yano S., Watanabe K. Involvement of CGRP, substance P and blood circulation in aggravating mechanism of absolute ethanol-induced antral lesions by capsaicin treatment in rats. Jpn. J. Pharmacol. 62:1993;123-129.
24. Uchida M., Gomori A., Yano S., Watanabe K., Kato Y. Studies on establishment of a simple method for gastric antral ulcer in rats and on the related pharmacological factors. Ulcer Res. 24:1997;89-92. (abstract in English).
25. Uwe P., Otfried S. Diethyldithiocarbamate delays gastric emptying and increases gastric acidity in rats in vivo. Pharmacol. Toxicol. 67:1990;188-190.