Prodrugs for systemic bioreductive activation-independent delivery of phyllohydroquinone, an active form of phylloquinone (vitamin K1) 1: Preparation and in vitro evaluation

Biological and Pharmaceutical Bulletin

Volumn 22, Issue 12, 1999, Pages 1347-1354

  Takata, Jiro ^a   Karube, Yoshiharu ^a   Matsunaga, Kazuhisa ^a   Hanada, Mitsunobu ^a   Hidaka, Ryoji ^a   Matsushima, Yoshikazu ^b  

^a FUKUOKA UNIVERSITY   (Japan)

^b KEIO UNIVERSITY   (Japan)

Author keywords

Bioreductive activation; Drug delivery; Phyllohydroquinone; Phylloquinone; Prodrug; Warfarin

Indexed keywords

CARBOXYLESTERASE; HYDROQUINONE DERIVATIVE; PHYSOSTIGMINE; PHYTOMENADIONE; PRODRUG; VITAMIN K GROUP; WARFARIN;

ANIMAL EXPERIMENT; ARTICLE; CARBOXYLATION; DRUG ACTIVATION; DRUG DELIVERY SYSTEM; DRUG HYDROLYSIS; DRUG SOLUBILITY; ENZYME MECHANISM; ESTERIFICATION; LIVER MICROSOME; MALE; NONHUMAN; RAT; REDUCTION;

EID: 0033372651     PISSN: 09186158     EISSN: None     Source Type: Journal    
DOI: 10.1248/bpb.22.1347     Document Type: Article

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