Small-intestinal mucosal protein synthesis and whole-body protein turnover in alcoholic liver disease

Clinical Science

Volumn 97, Issue 6, 1999, Pages 633-638

  Nakshabendi, I M ^a   Downie, S ^b   Russell, R I ^a   Rennie, M J ^b  

^a GLASGOW ROYAL INFIRMARY   (United Kingdom)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Alcoholic liver disease; Protein turnover; Small intestine; Stable isotopes

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ASPARTATE AMINOTRANSFERASE; BILIRUBIN; GAMMA GLUTAMYLTRANSFERASE; LEUCINE; SPIRONOLACTONE;

ADULT; ALCOHOL CONSUMPTION; ALCOHOL LIVER DISEASE; ARTICLE; CELL SIZE; CLINICAL ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; DISEASE SEVERITY; DUODENUM BIOPSY; ENDOSCOPY; FLUID RETENTION; HUMAN; INTESTINE MUCOSA; ISOTOPE LABELING; MUCOSA CELL; PRIORITY JOURNAL; PROTEIN METABOLISM; PROTEIN SYNTHESIS; SMALL INTESTINE;

EID: 0033371258     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/cs0970633     Document Type: Article

References (27)

1. 1 Blendis, L. M. (1992) Nutritional management of alcohol-related disease. In Human Nutrition and Dietetics, 9th edn. (Garrow, J. S., James, W. P. T. and Ralph, A., eds.), pp. 738-751, Churchill Livingstone, Edinburgh
2. 2 World, M. J., Ryle, P. R. and Thomson, A. D. (1985) Alcoholic malnutrition and the small intestine. Alcohol Alcohol. 20, 89-124
3. 3 O'Keefe, S. J. D., El Zaydi, A., Carrahet, T., Davis, M. and Williams, R. (1980) Malnutrition and immune competence in patients with liver disease. Lancet i, 615-617
4. 4 Mendenhall, C. L., Anderson, S., Weesner, R. E., Goldberg, S. J. and Crolic, K. A. (1984) Protein-calorie malnutrition associated with alcoholic hepatitis. Am. J. Med. 76, 211-222
5. 5 Morgan, M. Y. (1982) Alcohol and nutrition. Br. Med. Bull. 38, 21-29
6. 6 Shenkin, A. (1979) Assessment of nutritional status: the biochemical approach and its problems in liver disease. J. Hum. Nutr. 33, 341-349
7. 7 Swart, G. R., van den Berg, J. W. O., Wattimena, J. L. D., Rietveld, T., van Vuure, J. K. and Frenkel, M. (1988) Elevated protein requirements in cirrhosis of the liver investigated hy whole-body protein turnover studies. Clin. Sci. 75, 101-107
8. 8 Marway, J. S., Keating, J., Reeves, J., Salisbury, J. R. and Preedy, V. R. (1993) Seromuscular and mucosal protein synthesis in various anatomical regions of the rat gastrointestinal tract and their response to acute ethanol toxicity. J. Gastroenterol. Hepatol. 5, 27-34
9. 9 Preedy, V. R., Duane, P. and Peters, T. J. (1988) Acute ethanol dosage reduces the synthesis of smooth muscle contractile proteins in the small intestine of the rat. Gut 29, 1244-1248
10. 10 Preedy, V. and Peters, T. J. (1990) Protein synthesis of muscle fractions from the small intestine in alcohol fed rats. Gut 31, 305-310
11. 11 Mills, P. R., Shenkin, A., Anthony, R. S. et al. (1983) Assessment of nutritional status and in vivo immune responses in alcoholic liver disease. Am. J. Clin. Nutr. 38, 849-859
12. 12 Schwenk, W. F., Berg, P. J., Beaufrere, B., Miles, J. M. and Haymond, M. W. (1984) Use of t-butyldimethylsilylation in the gas chromatographic-mass spectrometric analysis of physiologic compounds found in plasma using electron-impact ionization. Anal. Biochem. 141, 101-109
13. 13 Fleck, A. and Munro, H. N. (1962) The precision of ultraviolet absorption measurements in the Schmidt-Thannhauser procedure for nucleic acid estimation. Biochim. Biophys. Acta 55, 571-583
14. 14 Nakshabendi, I. M., Obeidat, W., Russell, R. I., Downie, S., Smith, K. and Rennie, M. J. (1995) Gut mucosal protein synthesis measured using intravenous and intragastric delivery of stable tracer amino acids. Am. J. Physiol. 269, E996-E999
15. 13C enrichment by isotope ratio mass spectrometry. Biomed. Environ. Mass Spectrom. 17, 267-273
16. 16 Wolfe, R. R., Goodenough, R. D., Wolfe, M. H., Royle, G. T. and Nadel, E. R. (1982) Isotopic analysis of leucine and urea metabolism in exercising humans. J. Appl. Physiol. 52, 458-466
17. 17 Morrison, W. L., Bouchier, I. A. D., Gibson, J. N. A. and Rennie, M. J. (1990) Skeletal muscle and whole-body protein turnover in cirrhosis. Clin. Sci. 78, 613-619
18. 18 Schneeweiss, B., Graninger, W., Ferenci, P. et al. (1990) Energy metabolism in patients with acute and chronic liver disease. Hepatology 11, 387-393
19. 19 Gabuzda, G. J. and Shear, L. (1970) Metabolism of dietary protein in hepatic cirrhosis. Nutritional and clinical considerations. Am. J. Clin. Nutr. 23, 479-487
20. 20 Marchesini, G., Bianchi, G. P., Vilstrup, H., Checchia, G. A., Patrono, D. and Zoli, M. (1987) Plasma clearances of branched-chain amino acids in control subjects and in patients with cirrhosis. J. Hepatol. 4, 108-117
21. 21 Iber, F. L., Rosen, H. and Levenson, S. M. (1957) The plasma amino acids in patients with liver failure. J. Clin. Lab. Med. 50, 417-425
22. 22 Rosen, H., Yoshimura, N. and Hodgman, J. (1977) Plasma amino acid patterns in hepatic encephalopathy in differing aetiology. Gastroenterology 72, 483-487
23. 23 Hajjar, J. J., Tomicic, T. and Scheig, R. L. (1981) Effect of chronic ethanol consumption on leucine absorption in the rat small intestine. Digestion 22, 170-176
24. 24 Martines, D., Morris, A. I. and Billington, D. (1989) The effect of chronic ethanol intake on leucine absorption from the rat small intestine. Alcohol Alcohol. 24, 525-531
25. 25 Krasner, N., Cochran, K. M., Russell, R. I., Carmichael, H. A. and Thompson, G. G. (1976) Alcohol and absorption from the small intestine. I. Impairment of absorption from the small intestine in alcoholics. Gut 17, 245-248
26. 26 Barona, E., Pirola, R. C. and Lieber, C. S. (1974) Small intestinal damage and changes in cell population produced by ethanol ingestion in the rat. Gastroenterology 66, 226-234
27. 27 Nakshabendi, I. M., Downie, S., Rennie, M. J. and Russell, R. I. (1996) Increased rates of duodenal mucosal protein synthesis in vivo in patients with untreated coeliac disease. Gut 39, 176-179