The effect of age on odor-stimulated functional MR imaging

American Journal of Neuroradiology

Volumn 20, Issue 4, 1999, Pages 600-608

  Yousem, David M ^a,b   Maldjian, Joseph A ^b   Hummel, Thomas ^b   Alsop, David C ^a   Geckle, Rena J ^b   Kraut, Michael A ^a   Doty, Richard L ^b  

^a HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

^b JOHNS HOPKINS HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGE; AGED; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENDER; HUMAN; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; OLFACTORY DISCRIMINATION; OLFACTORY NERVOUS SYSTEM; RIGHT HANDEDNESS; SMELLING;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; AGING; BRAIN; ECHO-PLANAR IMAGING; FEMALE; FRONTAL LOBE; FUNCTIONAL LATERALITY; GYRUS CINGULI; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; ODORS; OLFACTORY PATHWAYS; PHYSICAL STIMULATION; SMELL; TEMPORAL LOBE;

EID: 0033361001     PISSN: 01956108     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (51)

1. Yousem DM, Williams SC, Howard RO, et al. Functional MR imaging during odor stimulation: preliminary data. Radiology 1997:204:833-838
2. Levy LM, Henkin RI, Hutter A, Lin CS, Martins D, Schellinger D. Functional MRI of human olfaction. J Comput Assist Tomogr 1997:21:849-856
3. Levy LM, Henkin Rl, Hutter A, Lin CS, Schellinger D. Mapping brain activation to odorants in patients with smell loss by functional MRI. J Comput Assist Tomogr 1998;22:96-103
4. Koizuka I, Yano H, Nagahara M, et al. Functional imaging of the human olfactory cortex by magnetic resonance imaging. OKL J Otorhinolaryngol Relat Spec 1994:56:273-275
5. Kettenmann B, Jousmaki V, Portin K, Salmelin R, Kobal G, Hari R. Odorants activate the human superior temporal sulcus. Neurosci Lett 1996;203:143-145
6. Sobel N, Prabhakaran V, Hartley ÇA, et al. Odorant-induced and sniff-induced activation in the cerebellum of the human. J Neurosci 1998:18:8990-9001
7. Doty RL. Influence of age and age-related diseases on olfactory function. Ann N ¥Acacl Sei 1989:561:76-86
8. Doty RL, Applebaum S, Zusho H, Settle RG. Sex differences in odor identification ability: a cross-cultural analysis. Neuropsychohgia 1985:23:667-672
9. Doty RL, Brugger WE, Jurs PC, Orndorff MA, Snyder PJ, Lowry LD. Intranasal trigeminal stimulation from odorous volatiles: psychometric responses from anosmic and normal humans. Physiol Behav 1978;20:175-185
10. Deems DA, Doty RL. Age-related changes in the phenyl ethyl alcohol odor detection threshold. Trans Penn Acad Ophthalmol Ototaryngol 1987;39:646-650
11. Doty RL, Shaman P, Kimmelman CP, Dann MS. University of Pennsylvania Smell Identification Test: a rapid quantitative olfactory function test for the clinic. Laryngoscope 1984;94: 176-178
12. Doty RL, Shaman P, Dann M. Development of the University of Pennsylvania Smell Identification Test: a standardized microencapsulated test of olfactory function. Physiol Behav 1984; 32:489-502
13. Doty RL, Shaman P, Applebaum SL, Giberson R, Siksorski L, Rosenberg L. Smell identification ability: changes with age. Science 1984;226:1441-1443
14. Kopala LC, Good K, Honer WO. Olfactory identification ability in pro- and postmenopausal women with schizophrenia. Dial Psychiatry 1995;38:57-63
15. Murphy C. Cognitive and chemosensory influences on age-related changes in the ability to identify blended foods. J Gerontol 1985;40:47-52
16. Murphy C. Age-related effects on the threshold, psychophysical function, and pleasantness of menthol. J Gerontol 1983; 38:217-222
17. Briggs CG, Nebes RD. Patterns of hand preference in a student population. Cortex 1975; 11:230-238
18. Deems DA, Doty RL, Settle RG, et al. Smell and taste disorders: a study of 750 patients from the University of Pennsylvania Smell and Taste Center. Arch Otolaryngol Head Neck Surg 1991:117:519-528
19. Hummel T, Pietsch H, Kobal G. Kallmann's syndrome and chemosensory evoked potentials. Eiir Arch Otorhinolaryngol 199I;248:311-312
20. Kobal G, Hummel C. Cerebral chemosensory evoked potentials elicited by chemical stimulation of the human olfactory and respiratory nasal mucosa. Electroencephalogr Clin Neurophysiol 1988:71:241-250
21. Sobel N, Prabhakaran V, Desmond JE, et al. Sniffing and smelling: separate subsystems in the human olfactory cortex. Nature 1998:392:282-286
22. Fristen KJ, Frith CD, Liddle PF, Frackowiak RS. Comparing functional (PET) images: the assessment of significant change. J Cereb Blood Flow Metab 1991;11:690-699
23. Fristen KJ, Worsley KJ, Frackowiak RSJ, Mazziotta JC, Evans AC. Assessing the significance of focal activations using their spatial extent. Hum Brain Map 1994:1:214-220
24. Fristen KJ. Commentary and opinion, II: statistical parametric mapping: ontology and current issues. J Cereb Blood Flow Aietab 1995:15:361-370
25. Fristen K, Holmes A, Worsley K, Poline J, Frith C, Frackowiak R. Statistical parametric maps in functional imaging: a general approach. Hum Brain Map 1995:2:189-201
26. Fristen K, Ahbumer J, Poline J, Frith C, Heather J, Frackowiak R. Spatial realignment and normalization of images. Hum Brain Map 1995:2:202-214
27. Fristen KJ, Frith CD, Liddle PF, Dolan RJ, Lammertsma AA, Frackowiak RS. The relationship between global and local changes in PET scans [see comments]. J Cereb Blood Flow Alelab 1990:10:458-466
28. Levin JM, Ross MH, Mendelson JH, Mello NK, Cohen BM, Renshaw PE Sex differences in blood-oxygenation-lcvcl-dcpendent functional MRI with primary visual stimulation. Am J Psychiatry 1998:155:434-436
29. Gur RC, Gur RE, Obrist WD, et al. Sex and handedness differences in cerebral blood flow during rest and cognitive activity. Science 1982;2I7:659-661
30. Gur RC, Mozley LH, Mozley PD, et al. Sex differences in regional cerebral glucose metabolism during a resting state. Science 1995:267:528-531
31. Andreason PJ, Zametkin AJ, Guo AC, Baldwin P, Cohen RM. Gender-related differences in regional cerebral glucose metabolism in normal volunteers. Psychiatry Res 1994:51:175-183
32. Miura SA, Schapiro MB, Grady CL, et al. Effect of gender on glucose utilization rates in healthy humans: a positron emission tomography study. J Neurosci Res 1990:27:500-504
33. Azari NP, Rapoport SI, Salerno JA, et al. Interregional correlations of resting cerebral glucose metabolism in old and young women. Brain Res 1992:589:279-290
34. Grady CL, Maisog JM, Horwitz B, et al. Age-related changes in cortical blood flow activation during visual processing of faces and location. J Neurosci 1994;I4:1450-1462
35. Ross MH, Yurgelun-Todd DA, Renshaw PF, et al. Age-related reduction in functional MRI response to photic stimulation. Neurology 1997;48:173-176
36. Hatazawa J, Brooks RA, Di Chiro G, Campbell G. Global cerebral glucose utilization is independent of brain size: a PET study. J Comput Assist Tomogr 1987; 11:571-576
37. Zatorre RJ, Jones-Gotman M, Evans AC, Meyer E. Functional localization and latcralization of human olfactory cortex. Nature 1992:360:339-340
38. Kraut MA, Marenco S, Soher BJ, Wong DF, Bryan RN. Comparison of functional MR and H2 ISO positron emission tomography in stimulation of the primary visual cortex. AJNR Am J Neuroradiol 1995; 16:2101-2107
39. Kraut M, Hart J Jr, Sober BJ, Gordon B. Object shape processing in the visual system evaluated using functional MRI. Nciirology I997;48:1416-1420
40. Gilbert AN, Greenbcrg MS, Beauchamp GK. Sex, handedncss and side of nose modulate human odor perception [published erratum appears in Neuropsychologia 1989;27:1313]. Neuropsychologia 1989;27:505-511
41. Evans WJ, Cui L, Starr A. Olfactory event-related potentials in normal human subjects: effects of age and gender. Eleclroencephalogr Clin Neiirophysiol 1995;95:293-301
42. Cowell PE, Turetsky BI, Gur RC, Grossman Rl, Shtasel DL, Gur RE. Sex differences in aging of the human frontal and temporal lobes. J Neurosci 1994;14:4748-4755
43. Gur RC, Mozley PD, Resnick SM, et al. Gender differences in age effect on brain atrophy measured by magnetic resonance imaging. Proc Natl Acad Sei USA 1991;88:2845-2849
44. Gur RE, Gur RC. Gender differences in regional cerebral blood flow. Schizophrenia Bull 1990:16:247-254
45. Doty RL, Rcyes PR Gregor T. Presence of both odor identification and detection deficits in Alzheimer's disease. Brain Res Bull 1987;18:597-600
46. Doty RL. Olfactory capacities in aging and Alzheimer's disease: psychophysical and anatomic considerations. Ann NY Acail Sei 1991:640:20-27
47. Doty RL, Perl DP, Steele JC, et al. Olfactory dysfunction in three neurodegenerative diseases. Geriatrics 1991:46:47-51
48. Serby M, Larson P, Kalkstein D. The nature and course of olfactory deficits in Alzheimer's disease. Am J Psychiatry 1991; 148:357-360
49. Rezek DL. Olfactory deficits as a neurologic sign in dementia of the Alzhcimer type. Arch Neural 1987:44:1030-1032
50. Bacon AW, Hartwell V, Quinones R, et al. The role of apolipoprotein-E and olfactory functioning in people with Alzheimer's disease. Presented at the International Symposium on Smell and Taste, San Diego, 1997
51. Doty RL, Li C, Mannon LJ, Yousem DM. Olfactory dysfunction in multiple sclerosis [letter]. W Engl J Med 1997;336:1918-1919