Three HTRF methods provide sensitivity for miniaturization in high-throughput screening

Laboratory Robotics and Automation

Volumn 11, Issue 6, 1999, Pages 324-329

  Upham, Loraine V ^a  

^a Packard Instrument Company   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; BIOASSAY; ENZYME INHIBITION; SENSITIVITY ANALYSIS;

HIGH-THROUGHPUT SCREENING; HOMOGENEOUS TIME-RESOLVED FLUORESCENCE (HTRF) ASSAYS;

ROBOTICS;

EID: 0033345012     PISSN: 08957533     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2728(1999)11:6<324::AID-LRA5>3.0.CO;2-E     Document Type: Article

References (6)

1. Mathis, G. Probing molecular interactions with homogeneous techniques based on rare earth cryptates and fluorescence energy transfer. Clin Chem 1995, 41(9), 1391-1397.
2. Kolb, A.; Harrison, P.; Mathis, G. Time-resolved fluorescent assay technology. Lab News 1997, Jan, 12-17.
3. Fox, S. Packard applies HTRF tool to high-through-put screens. Gen Eng News 1996, 16(19).
4. Kolb, A., et al. Tyrosine kinase assays adapted to homogeneous time-resolved fluorescence. Drug Discovery Today 1998, 3(7), 333-342.
5. Park, Y -W.; Cummings, R.; Hermes, J. 3rd Annual Meeting of the Society for Biomolecular Screening, September 22-25, San Diego, CA, 1997.
6. Wang, C.; Burke, J.; Mercier, M.; Park, Y -W.; Hermes, J. Assay Miniaturization for HTS: Development of Homogeneous Time-Resolved Fluorescence (HTRF) Assays in the 384-well Format. Presented at the Society for Biomolecular Screening Conference, September 1997, San Diego, CA.