Effective genetic therapy of established medullary thyroid carcinomas with murine interleukin-2: Dissemination and cytotoxicity studies in a rat tumor model

Endocrinology

Volumn 140, Issue 5, 1999, Pages 2152-2158

  Zhang, Rusheng ^a   Straus, Francis H ^a   DeGroot, Leslie J ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL DESTRUCTION; CANCER IMMUNOTHERAPY; CONTROLLED STUDY; GENE THERAPY; IMMUNOSTIMULATION; NONHUMAN; PRIORITY JOURNAL; RAT; THYROID MEDULLARY CARCINOMA;

EID: 0033325218     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.140.5.6719     Document Type: Article

References (40)

1. Immunity to tumors
2. Immune response against tumors
3. Expression of CD80 enhances immunogenicity of cervical carcinoma cells in vitro
4. Induction of autologous tumor-specific cytotoxic T-lymphocyte activity against a human renal carcinoma cell line by B7-1 (CD80) costimulation
5. Gene-modified tumor cells as cellular vaccine
6. Therapeutic effectiveness of the immunity elicited by P815 tumor cells engineered to express the B7-2 costimulatory molecule
7. Tumor cell expression of B7 costimulatory molecules and interleukin-12 or granulocyte-macrophage colony-stimulating factor induces a local antitumor response and may generate systemic protective immunity
8. Role of major histocompatibility complex class I α1/α2 domain polymorphism and in vivo expression pattern in tumor resistance: Studies with transgenic mice and lymphoma cell transfectants
9. Gene therapy for lung cancer
10. Tumor cells engineered to produce cytokines or cofactors as cellular vaccines: Do animal studies really support clinical trials?
11. Enhanced antitumor efficacy in mice by combination treatment with interleukin-1α and interferon-α
12. Role of neutrophils and lymphocytes in inhibition of a mouse mammary adenocarcinoma engineered to release IL-2, Il-4, IL-7, IL-10, IFN-α, IFN-γ and TNF-α
13. Enhancement of interleukin-4-mediated tumor regression in athymic mice by in situ retroviral gene transfer
14. Murine interleukin-4 displays potent anti-tumor activity in vivo
15. Interleukin 6 gene transfecion into Lewis lung carcinoma tumor cells suppress the malignant phenotype and confers immunotherapeutic competence against parental metastatic cells
16. Genetic modification of a murine fibrosarcoma to produce interleukin 7 stimulates host cell infiltration and tumor immunity
17. TGF-β contributes to the shift toward Th2-type response through direct and IL-10-mediated pathways in tumor-bearing mice
18. Antitumor effects of interleukin-12 (IL12): Applications for the immunotherapy and gene therapy of cancer
19. Macrophage colony-stimulating factor gene transduction into human lung cancer cells differentially regulates metastasis formations in various organ microenvironments of natural killer cell-depleted SCID mice
20. Immunotherapy of prostate cancer in the Dunning rat model: Use of cytokine gene modified tumor vaccines
21. Gene transfer for cytokine functional studies in the lung: The multifunctional role of GM-CSF in pulmonary inflammation
22. Genetic immunotherapy of established tumor with adenoviral-murine granulocyte-macrophage colony-stimulating factor
23. Interleukin-2 toxicity
24. Intratumoral injection of an adenovirus expressing interleukin-2 induces regression and immunity in a murine breast cancer model
25. Regression of bladder tumors in mice treated with interleukin 2 gene-modified tumor cells
26. The role of IL-2 secreted from genetically modified tumor cells in the establishment of antitumor immunity
27. Long term survival of immunocompetent rats with intraperitoneal colon carcinoma tumors using herpes simplex thymidine kinase/ganciclovir and IL-2 treatments
28. The role of interleukin-2 in combination adenovirus gene therapy for head and neck cancer
29. Complete recovery of mice from a pre-established tumor by direct intratumoral delivery of an adenovirus vector harboring the murine IL-2 gene
30. Combination gene therapy for oral cancer in a murine model
31. Recombinant adenoviruses as vaccines
32. Immunotherapy for medullary thyroid carcinoma by a replication-defective adenovirus transducing murine interleukin-2
33. Genetic immunotherapy for medullary thyroid carcinoma: Destruction of tumors in mice by in vivo delivery of adenoviral vector transducing the murine interleukin-2 gene
34. A new technique for the assay of infectivity of human adenovirus 5 DNA
35. Characterization of a human cell line transformed by DNA from human adenovirus type 5
36. Measurement of human and murine interleukin-2 and interleukin-4
37. Characterization of the antitumor immune response generated by treatment of murine tumors with recombinant adenoviruses expressing HSVtk, IL-2, IL-6, or B7-1
38. Pre-existing immunity to adenovirus does not prevent tumor regression following intratumoral administration of a vector expressing IL-12 but inhibits virus dissemination
39. The route of administration is a major determinant of the transduction efficiency of rat tissues by adenoviral recombinants
40. Isolated-organ perfusion for local gene delivery: Efficient adenovirus-mediated gene transfer into the liver