Intrinsic site-specific differences in the expression of leptin in human adipocytes and its autocrine effects on glucose uptake

Journal of Clinical Endocrinology and Metabolism

Volumn 84, Issue 7, 1999, Pages 2550-2556

  Zhang, Hui H ^a   Kumar, Sudhesh ^a   Barnett, Anthony H ^a   Eggo, Margaret C ^a,b  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b QUEEN ELIZABETH HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; INSULIN; LEPTIN;

ADIPOCYTE; ADULT; AGED; ARTICLE; AUTOCRINE EFFECT; BODY WEIGHT; CONTROLLED STUDY; FEMALE; GLUCOSE TRANSPORT; HORMONE ACTION; HORMONE DETERMINATION; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; LIPOGENESIS; MALE; NORMAL HUMAN; OBESITY; OMENTUM; PRIORITY JOURNAL; PROADIPOCYTE; SATIETY; SUBCUTANEOUS FAT;

EID: 0033306150     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.84.7.2550     Document Type: Article

References (60)

1. Congenital leptin deficiency is associated with severe early-onset obesity in humans
2. A leptin missense mutation associated with hypogonadism and morbid obesity
3. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction
4. Effects of the obese gene product on body weight regulation in ob/ob mice
5. Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor
6. Abnormal splicing of the leptin receptor in diabetic mice
7. Specificity of leptin action on elevated blood glucose and hypothalamic neuropeptide Y gene action in ob/ob mice
8. The role of neuropeptide Y in the antiobesity action of the obese gene product
9. Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reducing subjects
10. Overexpression of the obese (ob) gene in adipose tissue of human obese subjects
11. Relationship between insulin sensitivity and plasma leptin concentration in lean and obese men
12. Serum leptin concentrations, obesity and insulin resistance in West Samoans: A cross-sectional study
13. Hyperleptinemia: The missing link in the metabolic syndrome
14. The down-regulation of the expression of the obese gene by antidiabetic thiazolidinedione in Zucker diabetic fatty Rats and db/db mice
15. Effect of troglitazone on leptin production. Studies in vitro and in human subjects
16. Quantification of the full-length leptin receptor (OB-Rb) in human brown and white adipose tissue
17. Leptin receptor isoforms expressed in human adipose tissue
18. Lack of effect of leptin on glucose transport, lipoprotein lipase, and insulin action in adipose and muscle cells
19. Evidence against a direct effect of leptin on glucose transport in skeletal muscle and adipocytes
20. Leptin does not affect adipocyte glucose metabolism: Studies in fresh and cultured adipocytes
21. Leptin inhibits insulin binding in isolated rat adipocytes
22. Leptin impairs metabolic actions of insulin in isolated rat adipocytes
23. Leptin inhibits insulin-stimulated incorporation of glucose into lipids and stimulates glucose decarboxylation in isolated rat adipocytes
24. Direct effects of leptin on brown and white adipose tissue
25. Modulation of insulin activities by leptin
26. Difference in leptin mRNA levels between omental and subcutaneous abdominal tissue from obese humans
27. Depot- and sex-specific differences in human leptin mRNA expression: Implications for the control of regional fat distribution
28. Depot-specific differences in adipose tissue gene expression in lean and obese subjects
29. Leptin secretion from subcutaneous and visceral adipose tissue in women
30. Metabolism of isolated fat cells: Effect of hormones on glucose metabolism and lipolysis
31. In vitro insulin resistance of human adipocytes isolated from subjects with non-insulin-dependent diabetes mellitus
32. Long-term effect of insulin on glucose transport and insulin binding in cultured adipocytes from normal and obese humans with and without non-insulin-dependent diabetes
33. A simple, rapid, and sensitive DNA assay procedure
34. Basic principles of three rapid fluorochrome assays for DNA quantification and cell counting
35. Methods for the isolation and characterization of nonhistone chromosomal protein
36. Proliferation of unilocular fat cells in the primary culture
37. Fading of immunofluorescence during microscopy: A study of the phenomenon and its remedy
38. Acute and chronic effect of insulin on leptin production in humans
39. Regulation of expression of ob mRNA and protein by glucocorticoids and cAMP
40. Dexamethasone, OB gene, and leptin in humans; effect of exogenous hyperinsulinemia
41. Relationship between plasma leptin concentration and body fat, gender, diet, age, and metabolic covariates
42. Ligand-independent dimerization of the extracellular domain of the leptin receptor and determination of the stoichiometry of leptin binding
43. Effect of leptin on insulin signalling in rat-1 fibroblasts overexpressing HIR
44. A nutrient-sensing pathway regulates leptin gene expression in muscle and fat
45. Transport and metabolism of D-glucose in human adipocytes. Studies of the dependence on medium glucose and insulin concentrations
46. Obese gene expression alters the ability of 30A5 preadipocytes to respond to lipogenic hormones
47. Insulin resistance: An adaptation for weight maintenance
48. Insulin-like growth factor-I is an essential regulator of the differentiation of 3T3-L1 adipocytes
49. Antidiabetic agent pioglitazone enhances adipocyte differentiation of 3T3-F442A cells
50. Insulin binding in differentiating rat preadipocytes in culture
51. CCAAT/enhancer binding protein α is sufficient to initiate the 3T3-L1 adipocyte differentiation program
52. Cell-free transcription directed by the 422 adipose P2 gene promoter: Activation by the CCAAT/enhancer binding protein
53. Steroid hormone receptors in human adipose tissues
54. Characterization of regional and gender differences in glucocorticoid receptors and lipoprotein lipase activity in human adipose tissue
55. Differences at the receptor and postreceptor levels between human omental and subcutaneous adipose tissue in the action of insulin on lipolysis
56. Tumor necrosis factor-α inhibits preadipocyte differentiation and increases leptin production in human adipose tissue
57. Enhanced expression of PAI-1 in visceral fat: Possible contributor to vascular disease in obesity
58. Omental and epigastric adipose tissue lipolytic activity in human obesity: Effect of abdominal fat distribution and relationship with hyperinsulinemia
59. A possible role for protein kinase C in the regulatory differences between intra-abdominal and subcutaneous human adipose tissue
60. Leptin and the regulation of body weight in mammals