α-Latrotoxin stimulates inward current, rise in cytosolic calcium concentration, and exocytosis in at pituitary gonadotropes

Endocrinology

Volumn 140, Issue 7, 1999, Pages 3025-3033

  Tse, Frederick W ^a   Tse, Amy ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA LATROTOXIN; CALCIUM ION; LUTEINIZING HORMONE; SPIDER VENOM;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL COMPARTMENTALIZATION; CONTROLLED STUDY; EXOCYTOSIS; GONADOTROPIN SECRETING CELL; HORMONE RELEASE; HYPOPHYSIS; ION CURRENT; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0033305580     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.140.7.6849     Document Type: Article

References (39)

1. α-Latrotoxin and related toxins
2. Binding of synaptotagmin to the α-latrotoxin receptor implicates both in synaptic vesicle exocytosis
3. Neurexins: Synaptic cell surface proteins related to the α-latrotoxin receptor and laminin
4. α-Latrotoxin receptor, latrophilin, is a novel member of the secretin family of G protein-coupled receptors
5. α-Latrotoxin stimulates exocytosis by the interaction with a neuronal G-protein-coupled receptor
6. Black widow spider venom: Effect of purified toxin on lipid bilayer membranes
7. α-Latrotoxin channels in neuroblastoma cells
8. 2+
9. α-Latrotoxin alters spontaneous and depolarization-evoked quantal release from rat adrenal chromaffin cells: Evidence for multiple modes of action
10. 2+](i)
11. 2+-independent receptor for α-latrotoxin, CIRL, mediates effects on secretion via multiple mechanisms
12. 2+
13. α-Latrotoxin receptor CIRL/latrophilin 1(CL1) defines an unusual family of ubiquitous G-protein-linked receptors
14. 2+-Independent insulin exocytosis induced by α-latrotoxin requires latrophilin, a G protein-coupled receptor
15. Rhythmic exocytosis stimulated by GnRH-induced calcium oscillations in rat gonadotropes
16. Inhibition of luteinizing-hormone exocytosis by guanosine 5'-γ-thio-triphosphate reveals involvement of GTP-binding protein distal to second-messenger generation
17. 2+-independent exocytosis in pituitary gonadotrophs
18. 2+](i) elevation and exocytosis in pituitary gonadotrophs
19. Patch clamping studies on identified pituitary gonadotropes in vitro
20. Detection of LH release from individual pituitary cells by the reverse hemolytic plaque assay
21. GnRH-induced Ca oscillations and rhythmic hyperpolarizations of pituitary gonadotropes
22. Calcium homeostasis in identified rat gonadotrophs
23. 2+ indicators with greatly improved fluorescence properties
24. 2+ concentrations in living cells
25. Improved patch-clamp techniques for high resolution current recording from cells and cell-free membrane patches
26. Studies on α-latrotoxin receptors in rat brain synapotosomes: Correlation between toxin binding and stimulation of transmitter release
27. 2+ and neurotransmitter release: Studies on PC12 cells and synaptosomes exposed to α-latrotoxin
28. α-Latrotoxin of black widow spider venom depolarizes the plasma membrane, induces massive calcium influx, and stimulates transmitter release in guinea pig brain synaptosomes
29. Fractional contribution of calcium to the cation current through glutamate receptor channels
30. Calcium permeability of nicotinic acetylcholine receptor channels in bovine adrenal chromaffin cells
31. Regulation of eukaryotic phosphatidylinositol-specific phospholipase C and phospholipase D
32. α-Latrotoxin of black widow spider venom binds to a specific receptor coupled to phosphoinositide breakdown in PC12 cells
33. 2+-release channels
34. Local calcium gradients generated by release from intracellular calcium stores regulate exocytosis in pituitary gonadotropes
35. Alien intracellular calcium chelators attenuate neurotransmitter release at the squid giant synapse
36. 2+
37. Calcium-independent actions of α-latrotoxin on spontaneous and evoked synaptic transmission in the hippocampus
38. 2+-independent release of neurotransmitter induced by α-latrotoxin
39. Molecular components of the exocytotic machinery in the rat pituitary gland